Satellite Glial Cells Bridge Sensory Neuron Crosstalk in Visceral Pain and Cross-Organ Sensitization

Journal of Pharmacology and Experimental Therapeutics, Год журнала: 2024, Номер 390(2), С. 213 - 221

Опубликована: Май 22, 2024

Following colonic inflammation, the uninjured bladder afferent neurons are also activated. The mechanisms and pathways underlying this sensory neuron cross-activation (from injured to neurons) not fully understood. Colonic reside in same spinal segments separated by satellite glial cells (SGCs) extracellular matrix dorsal root ganglia (DRG). SGCs communicate with a bidirectional fashion. This review summarizes differentially regulated genes/proteins DRG explores role of regulation crosstalk visceral cross-organ sensitization. highlights paracrine mediating neuron-SGC SGC-neuron coupling an emphasis on neurotrophins purinergic systems. Finally, I discuss results from recent RNAseq profiling reveal useful molecular markers for characterization, functional study, therapeutic targets SGCs. SIGNIFICANCE STATEMENT: Satellite largest subtypes play critical crosstalk, mechanism colon-bladder cross-sensitization. Identification novel unique can advance discovery treatment chronic pain including comorbidity.

Язык: Английский

Cellular and Molecular Mechanisms Underlying Altered Excitability of Cardiac Efferent Neurons in Cirrhotic Rats

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1722 - 1722

Опубликована: Авг. 1, 2024

Patients with cirrhosis often exhibit cardiac autonomic dysfunction (CAD), characterized by enhanced sympathetic activity and diminished vagal tone, leading to increased morbidity mortality. This study delineates the cellular molecular mechanisms associated altered neuronal activities causing cirrhosis-induced CAD. Biliary nonbiliary cirrhotic rats were produced common bile duct ligation (CBDL) intraperitoneal injections of thioacetamide (TAA), respectively. Three weeks after CBDL or TAA injection, assessment heart rate variability revealed imbalance in rats. We observed excitability stellate ganglion (SG) neurons decreased intracardiac (ICG) compared sham-operated controls. Additionally, threshold, rheobase, action potential duration exhibited opposite alterations SG ICG neurons, along changes afterhyperpolarization duration. A- M-type K⁺ channels significantly downregulated while upregulated, downregulation N- L-type Ca

Язык: Английский

Optimization of an autaptic culture system for studying cholinergic synapses in sympathetic ganglia

Pflügers Archiv - European Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Язык: Английский