Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721
Опубликована: Авг. 15, 2024
Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.
Язык: Английский
Процитировано
12
Опубликована: Июль 12, 2024
Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.
Язык: Английский
Процитировано
10
Frontiers in Aging, Год журнала: 2025, Номер 5
Опубликована: Янв. 6, 2025
Memory formation is associated with constant modifications of neuronal networks and synaptic plasticity gene expression in response to different environmental stimuli experiences. Dysregulation affects memory during aging neurodegenerative diseases. Covalent such as methylation on DNA acetylation histones regulate the transcription genes. Changes these epigenetic marks correlated alteration aging. These modifications, turn, are regulated by physiology metabolism. Steroid hormone estrogen metabolites S-adenosyl methionine acetyl CoA directly impact histones' levels. Thus, decline levels or imbalance underlying brain functions. In present review, we discussed importance histone chromatin regulation consolidation, modulation modifiers phytochemicals vitamins. Further, understanding molecular mechanisms that modulate will help develop recovery approaches.
Язык: Английский
Процитировано
2
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Язык: Английский
Процитировано
0