Combating Breast Cancer-associated Metastasis using Paclitaxel and Tranilast-loaded Human Serum Albumin Nanoparticles DOI
Naitik Jain,

Syed Shahrukh,

Paras Famta

и другие.

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Май 22, 2025

The objective of the current study is to combat breast cancer-associated metastasis using paclitaxel (PTX) and tranilast (TRA)-loaded human serum albumin (HAS) Nanoparticles. This combinatorial therapy microtubule stabilizing agent PTX, along with TGFβ inhibitor TRA.TRA may offer an improved therapeutic effect in cancer by inhibiting cell proliferation metastasis. Inspired remarkable anticancer properties both drugs, they were encapsulated into HSA nanoparticles enhance tumor site-specific drug accumulation ensure sustained release over a prolonged period. fabricated desolvation method optimized Box-Behnken design (BBD) three-level, two-factor approach. Further, these characterized TEM, FTIR, XRD, particle size. In vitro experiments conducted MDA-MB-231 line, employing viability, cellular uptake, nuclear staining, scratch assay, cycle analysis. kinetics reveal PTX TRA from nanoparticles. Wound healing assay depicted anti-migratory activity PTX-TRA-NPs (30nM-75μM). Furthermore, novel combination treatment caused G2/M phase arrest, as indicated delivery hydrophobic drugs (PTX TRA) cells, offering outcomes. strategy permits further preclinical investigation for synergistic management.

Язык: Английский

Harnessing marine antimicrobial peptides for novel therapeutics: A deep dive into ocean-derived bioactives DOI
Kunal Agam Kanaujia,

Suraj Wagh,

Giriraj Pandey

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 307, С. 142158 - 142158

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0
Intra or extracellular: The location of piezotronic effect determines the polarization regulation of macrophages for enhanced wound healing DOI

Bo‐Jun Xie,

Shan Lu, Liang Wang

и другие.

Nano Energy, Год журнала: 2025, Номер unknown, С. 110893 - 110893

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing DOI

Pawan Jaiswal,

Giriraj Pandey,

Shivam Kumar

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106872 - 106872

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
o-Quinone trapping by stilbenoids DOI Creative Commons
Rosario Zamora, Francisco J. Hidalgo

Food Chemistry, Год журнала: 2025, Номер 484, С. 144381 - 144381

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Effects of Asiatic acid on brain cancer by altering astrocytes and the AKT1-PRKCB signaling pathway: A genomic and network pharmacology perspective DOI
Amit Kumar Singh, Ashutosh Pathak, Pradeep Kumar

и другие.

Brain Research, Год журнала: 2025, Номер unknown, С. 149652 - 149652

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Combating Breast Cancer-associated Metastasis using Paclitaxel and Tranilast-loaded Human Serum Albumin Nanoparticles DOI
Naitik Jain,

Syed Shahrukh,

Paras Famta

и другие.

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Май 22, 2025

The objective of the current study is to combat breast cancer-associated metastasis using paclitaxel (PTX) and tranilast (TRA)-loaded human serum albumin (HAS) Nanoparticles. This combinatorial therapy microtubule stabilizing agent PTX, along with TGFβ inhibitor TRA.TRA may offer an improved therapeutic effect in cancer by inhibiting cell proliferation metastasis. Inspired remarkable anticancer properties both drugs, they were encapsulated into HSA nanoparticles enhance tumor site-specific drug accumulation ensure sustained release over a prolonged period. fabricated desolvation method optimized Box-Behnken design (BBD) three-level, two-factor approach. Further, these characterized TEM, FTIR, XRD, particle size. In vitro experiments conducted MDA-MB-231 line, employing viability, cellular uptake, nuclear staining, scratch assay, cycle analysis. kinetics reveal PTX TRA from nanoparticles. Wound healing assay depicted anti-migratory activity PTX-TRA-NPs (30nM-75μM). Furthermore, novel combination treatment caused G2/M phase arrest, as indicated delivery hydrophobic drugs (PTX TRA) cells, offering outcomes. strategy permits further preclinical investigation for synergistic management.

Язык: Английский

Процитировано

0