Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study DOI Creative Commons
Marie Kupjetz, Martin Langeskov‐Christensen, Morten Riemenschneider

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Abstract Neuroaxonal damage in multiple sclerosis (MS) results from an interplay of neurotoxic pathomechanisms combined with a reduced neuroprotective capacity neurons and glia to resist damage. Kynurenine pathway (KP) imbalance resembles some the molecular mechanisms central incompletely understood MS pathophysiology. To study role KP MS, we performed targeted metabolomics on serum samples 353 persons 111 healthy individuals, detected MS-specific differences concentrations most kynurenines. Using exploratory factor analysis, then identified two distinct metabolite patterns: inflammation-driven pattern „NeuroTox“ „NeuroPro“. Our show that greater lower „NeuroPro“ were associated higher disease severity. The novelty our data-driven approach patterns advocates for future studies using comparable approaches investigate whether follows similar disease-specific diseases other than MS.

Язык: Английский

Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study DOI Creative Commons
Marie Kupjetz, Martin Langeskov‐Christensen, Morten Riemenschneider

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Abstract Neuroaxonal damage in multiple sclerosis (MS) results from an interplay of neurotoxic pathomechanisms combined with a reduced neuroprotective capacity neurons and glia to resist damage. Kynurenine pathway (KP) imbalance resembles some the molecular mechanisms central incompletely understood MS pathophysiology. To study role KP MS, we performed targeted metabolomics on serum samples 353 persons 111 healthy individuals, detected MS-specific differences concentrations most kynurenines. Using exploratory factor analysis, then identified two distinct metabolite patterns: inflammation-driven pattern „NeuroTox“ „NeuroPro“. Our show that greater lower „NeuroPro“ were associated higher disease severity. The novelty our data-driven approach patterns advocates for future studies using comparable approaches investigate whether follows similar disease-specific diseases other than MS.

Язык: Английский

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