Опубликована: Янв. 1, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 206, С. 107300 - 107300
Опубликована: Июль 9, 2024
Depression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. The pathogenesis of complex involves multiple signal transduction pathways molecular changes. PI3K/AKT pathway an essential signaling in neurons, which widely expressed emotion-related regions the brain. Therefore, play moderating role mood disorders. However, mechanism not been fully described. This review systematically summarized discussed its potential treatment depression. will help development antidepressants.
Язык: Английский
Процитировано
23
Encyclopedia, Год журнала: 2024, Номер 4(2), С. 1026 - 1043
Опубликована: Июнь 20, 2024
The stress response is a natural physiological reaction of the organism, elicited to maintain internal environment and evoke adaptive behaviors, ultimately leading survival. However, at turn century, stress-related disorders gained increasing significance. aim entry explore fundamental question when system changes from beneficial detrimental system, contributing higher risk development and/or diseases. To develop context, here, we different concepts reveal complexities, perspectives, multiple relationships between neurochemistry, cerebral functional network, associated pathologies. According literature, affects nearly every biological through close interactions physiological, nervous, endocrine, immune systems faced with real or perceived threat. Considering today’s challenging times, where people are facing unavoidable adversities in their lives level uncertainty never before seen, this review emphasizes importance understanding potential consequences being unable cope stressful events. Susceptibility resilience have recognition as important areas study. literature presented here enhances our identifies causes various psychopathologies, mental health conditions, disabilities, even mortality that closely linked vulnerability stress. Experimental studies recent decades demonstrated many factors affecting ability stress, including differences individuals due genetic background, epigenetic regulation, gender, early-life experiences. Finally, there an urgent need change paradigm modern lifestyles strategy prevent spread “health epidemic 21st century”, which Therefore, acknowledge approaches enhance resilience, focusing on perception, tolerance, positive lifestyle behaviors.
Язык: Английский
Процитировано
5
Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 108230 - 108230
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Neurochemistry, Год журнала: 2025, Номер 169(2)
Опубликована: Фев. 1, 2025
Oxidative stress-mediated astrocytic damage contributes to nerve injury and the development of depression, especially under stress conditions. Peroxisomes pexophagy are essential for balancing oxidative protein degradation products. Our previous findings suggest that peroxisome proliferators-activated receptor β/δ (PPARβ/δ) activation significantly alleviates depressive behaviors by preventing injury. However, underlying mechanisms remain unclear. In present study, we established treating astrocytes with corticosterone. Subsequently, PPARβ/δ agonists antagonists were applied determine effects on peroxisomes in astrocytes. The agonist (GW0742) improved cell viability decreased intracellular reactive oxygen species (ROS) production induced corticosterone, while pretreatment PPARβ/δ, antagonist GSK3787 reversed GW0742. Moreover, activating promoted peroxisomal biogenesis factor 5 (PEX5)-mediated enhancing phosphorylation ataxia-telangiectasia mutated (ATM) kinase. Conversely, blocking partially abolished Further investigations demonstrated not only transcription ubiquitin ligase E3 component n-recognin (UBR5) but also enhanced interaction between UBR5, contributing ATM interactor (ATMIN) degradation, increased phosphorylated kinase levels. Therefore, this study revealed improves corticosterone-induced pexophagy. directly interacts UBR5 facilitate ATMIN promotes phosphorylation, thereby maintaining balance These is a potential target promoting upon stress.
Язык: Английский
Процитировано
0
Journal of Hospitality Marketing & Management, Год журнала: 2025, Номер unknown, С. 1 - 19
Опубликована: Март 21, 2025
Язык: Английский
Процитировано
0
Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9
Опубликована: Янв. 1, 2025
Background Prolonged high-concentration cortisol exposure may impair cognitive function, but its mechanisms and risk factors remain unclear in humans. Objective Using Cushing's disease patients as a model, this study explores these effects develops predictive model to aid managing high-risk patients. Methods This single-center retrospective included 107 (January 2020–January 2024) at the First Medical Center of PLA General Hospital. Cognitive assessed using Montreal Assessment, revealed 58 with impairment 49 normal function. Patients were divided into training (n = 53) validation cohorts 54) for constructing validating model. Risk identified via univariate analysis least absolute shrinkage selection operator regression, nomogram prediction was developed. Performance evaluated receiver operating characteristic (ROC) curves, calibration decision curve (DCA). Results Cortisol AM/PM ratio, 8 a.m. concentration, body mass index, fasting plasma glucose significant impairment. The demonstrated strong ability, ROC values 0.80 (training) 0.91 (validation). DCA indicated superior clinical utility compared treating all or no Conclusions confirms impact prolonged high on function identifies key factors. offers robust performance, providing valuable tool patients’ health informing strategies other cortisol-related disorders.
Язык: Английский
Процитировано
0
Behavioural Brain Research, Год журнала: 2024, Номер unknown, С. 115318 - 115318
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3
Archives of Oral Biology, Год журнала: 2024, Номер 169, С. 106097 - 106097
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
2
Chinese Journal of Integrative Medicine, Год журнала: 2024, Номер 30(8), С. 747 - 758
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
1
Animal Cells and Systems, Год журнала: 2024, Номер 28(1), С. 439 - 452
Опубликована: Сен. 12, 2024
Glial cells play a significant role in maintaining brain homeostasis and normal development, their functions can be impaired by exposure to endocrine disruptors. 4-n-Nonylphenol (NP), representative disruptor, is widely used personal care products industrial materials. NP accumulates various organs, including the brain, of living organisms adversely influences health. However, studies on effects glial are limited. This study aims investigate using primary mixed offspring mice exposed during gestation lactation.
Язык: Английский
Процитировано
1