Neuropsychological Profiling of Colloid Cyst Patients: Domains Affected and Long-term Outcomes
Neurology India,
Год журнала:
2025,
Номер
73(1), С. 77 - 81
Опубликована: Янв. 1, 2025
Background:
Colloid
cysts
are
known
to
cause
neuropsychological
impairment.
However,
the
specific
domains
that
affected
and
their
outcomes
following
excision
not
studied
in
past.
In
current
study,
we
evaluated
different
involved
colloid
cyst
patients
how
they
fared
on
long-term
follow-up
after
excision.
Methods:
A
retrospective
cohort
of
sixteen
managed
a
tertiary
care
center
were
included
study.
The
clinical
presentation,
largest
diameter,
presence
ventriculomegaly
using
Evans
index
noted
an
MR
brain
imaging
preoperatively.
neurocognitive
evaluation
was
performed
by
neuropsychologist
at
presentation
1
month
year
Results:
memory,
rate
learning,
verbal
fluency,
sustained
attention,
focused
information
processing
speed,
auditory
working
memory.
There
clinically
meaningful
improvement
visual
memory
(
P
=
0.054)
logical
0.058)
operated
patients,
while
other
parameters
improved
slightly.
No
significant
change
early
late
postoperative
assessments.
Conclusions:
Neurocognitive
Visual
show
postsurgical
decompression.
Язык: Английский
Hippocampal subfield volume differences between female-to-male transgender individuals with cross-sex hormone therapy and cisgender women
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Фев. 27, 2025
The
prevalence
of
female-to-male
(FtM)
transgender
individuals
has
risen
recently,
yet
the
effects
cross-sex
hormone
therapy
on
volumetric
differences
in
hippocampal
subfields
remain
poorly
understood.
This
study
aimed
to
evaluate
gray
matter
(GM)
volume,
especially
focusing
subfields,
FtM
and
premenopausal
cisgender
women.
Seventeen
who
had
undergone
hysterectomies
were
receiving
testosterone
before
participating
this
study,
along
with
20
women,
underwent
a
single
session
T1-weighted
magnetic
resonance
imaging
(MRI).
group
significantly
higher
free-testosterone
(free-T)
levels
lower
estradiol
compared
women
(p
<
0.001).
In
voxel-wise
analysis,
showed
larger
GM
volumes
caudate
nucleus,
hypothalamus,
thalamus
0.01,
FWE-corrected).
More
specifically,
right
subiculum
volume
was
0.05,
Bonferroni-corrected),
these
positively
correlated
free-T
(r
=
0.34,
p
0.04).
revealed
specific
subfield
testosterone-treated
when
group.
These
findings
might
help
elucidate
morphological
variation
cerebral
regions
associated
contribute
our
understanding
gender-affirming
treatments
as
well.
Язык: Английский
The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Июль 8, 2024
Background
Knee
Osteoarthritis
(KOA)
is
a
prevalent
and
debilitating
condition
affecting
millions
worldwide,
yet
its
underlying
etiology
remains
poorly
understood.
Recent
advances
in
neuroimaging
genetic
methodologies
offer
new
avenues
to
explore
the
potential
neuropsychological
contributions
KOA.
This
study
aims
investigate
causal
relationships
between
brain-wide
morphometric
variations
KOA
using
epidemiology
approach.
Method
Leveraging
data
from
36,778
UK
Biobank
participants
for
human
brain
morphometry
487,411
KOA,
this
research
employed
two-sample
Mendelian
Randomization
(TSMR)
approach
effects
of
83
volumes
on
The
primary
method
analysis
was
Inverse
Variance
Weighted
(IVW)
Wald
Ratio
(WR)
method,
complemented
by
MR
Egger
IVW
methods
heterogeneity
pleiotropy
assessments.
A
significance
threshold
p
<
0.05
set
determine
causality.
results
were
assessed
methods.
Brain-wide
with
Q_pval
considered
indicative
heterogeneity.
evaluate
results,
having
-value
suggestive
pleiotropy.
Results
Our
findings
revealed
significant
associations
eight
volumes:
Left
parahippocampal
volume,
Right
posterior
cingulate
transverse
temporal
caudal
anterior
paracentral
lateral
orbitofrontal
superior
volume.
These
remained
robust
after
tests
pleiotropy,
underscoring
their
role
pathogenesis
Conclusion
provides
novel
evidence
specific
morphometries
suggesting
that
neuroanatomical
might
contribute
risk
development
pave
way
further
into
neurobiological
mechanisms
may
eventually
lead
intervention
strategies
targeting
these
pathways.
Язык: Английский