Neuron-Astrocyte Interactions in Aging and Alzheimer's Disease: Dysregulation of Amyloid Precursor Protein DOI Creative Commons
Gretsen Velezmoro Jáuregui, Vladimir Parpura

Ageing & Longevity, Год журнала: 2025, Номер 2. 2025, С. 117 - 128

Опубликована: Фев. 27, 2025

Amyloid precursor protein (APP) is central to Alzheimer's disease (AD) by its role in Aβ build-up and neuronal astrocytic malfunction. The major risk factor for late-onset AD aging, which increases APP processing both neurons astrocytes, consequently production. This focused review covers the subjects of how aging affect dynamics within cell types astrocytes dysfunction can enhance neuroinflammation injury. We discuss interplay between brains, where bi-directional cellular interactions accelerate neurodegeneration. Keywords: protein, Alzheimer`s disease, amyloid beta, neurons, neuroinflammation, reactive astrogliosis

Язык: Английский

Neuron-Astrocyte Interactions in Aging and Alzheimer's Disease: Dysregulation of Amyloid Precursor Protein DOI Creative Commons
Gretsen Velezmoro Jáuregui, Vladimir Parpura

Ageing & Longevity, Год журнала: 2025, Номер 2. 2025, С. 117 - 128

Опубликована: Фев. 27, 2025

Amyloid precursor protein (APP) is central to Alzheimer's disease (AD) by its role in Aβ build-up and neuronal astrocytic malfunction. The major risk factor for late-onset AD aging, which increases APP processing both neurons astrocytes, consequently production. This focused review covers the subjects of how aging affect dynamics within cell types astrocytes dysfunction can enhance neuroinflammation injury. We discuss interplay between brains, where bi-directional cellular interactions accelerate neurodegeneration. Keywords: protein, Alzheimer`s disease, amyloid beta, neurons, neuroinflammation, reactive astrogliosis

Язык: Английский

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