Revista Mexicana de Trastornos Alimentarios/Mexican Journal of Eating Disorders, Год журнала: 2022, Номер 12(1), С. 88 - 104
Опубликована: Июль 1, 2022
Translational Psychiatry, Год журнала: 2022, Номер 12(1)
Опубликована: Авг. 15, 2022
Abstract Background Several pioneering studies investigated deep brain stimulation (DBS) in treatment-refractory anorexia nervosa (AN) patients, but overall effects remain yet unclear. Aim of this study was to obtain estimates efficacy DBS AN-patients using meta-analysis. Methods We searched three electronic databases until 1st November 2021, terms related and AN. included trials that the clinical AN-patients. obtained data including psychiatric comorbidities, medication use, target, duration. Primary outcome Body Mass Index (BMI), secondary quality life, severity symptoms, eating disorder, obsessive-compulsive, depressive, anxiety symptoms. assessed risk bias ROBINS-I tool. Results Four were for meta-analysis, with a total 56 patients Follow-up ranged from 6–24 months. Random meta-analysis showed significant increase BMI following DBS, large effect size (Hedges’s g = 1 ∙ 13; 95% CI 0 80 46; Z -value 6 75; P < 001), without heterogeneity ( I 2 00, 901). also life 86; 44 28; 4 01, 001). Furthermore, decreased symptoms 89; 57 21; 5 47; 001, 29, 371). Discussion In first statistically beneficial on weight restoration, reduction These outcomes call more extensive naturalistic determine relevance functional recovery. This is preregistered PROSPERO,CRD42022295712.
Язык: Английский
Процитировано
17
Journal of Psychiatric Research, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of the Neurological Sciences, Год журнала: 2022, Номер 437, С. 120253 - 120253
Опубликована: Апрель 10, 2022
Язык: Английский
Процитировано
13
World Neurosurgery, Год журнала: 2022, Номер 168, С. 179 - 189
Опубликована: Окт. 1, 2022
Anorexia nervosa and obesity are common appetite disorders, which may be life threatening if not treated often coincide with psychiatric disorders. We sought to investigate whether deep brain stimulation (DBS) of specific regions within the could aid in treatment these This review aims organize literature regarding feasibility DBS via clinical outcomes synthesize data on patient demographics electrode parameters for future optimization.PubMed, Scopus, Web Science databases were all queried 7 June 2022 identify studies reporting effect either anorexia or obesity. included involving 1) DBS, 2) obesity, 3) body mass index (BMI) as primary outcome variable. Case reports, retrospective cohort studies, randomized controlled trials eligible inclusion. Exclusion articles was based following criteria: meta-analyses systematic reviews describes diseases other than only Screening 999 returned by an initial search yielded 23 inclusion further extraction. Qualitative assessment subsequently conducted accordance Newcastle-Ottawa Scale criteria.We (17 anorexia, 5 obesity) that met our exclusion criteria, 8 case 13 series, 1 case-control study. Our variables interest location change BMI after intervention, parameters, comorbidities. A total 131 patients analyzed, 118 those belonging cohort. For we found most place subcallosal cingulate followed nucleus accumbens, resulting overall increase 24.82% over span a mean 17.1 months. Psychiatric comorbidities (major depressive disorder, obsessive-compulsive anxiety) lateral hypothalamus small decrease 3.97% 17.2 Data insufficient this report additional calculate duration from diagnosis treatment.DBS seems promising solution addressing treatment-refractory but prospective still needed confirm same usefulness Primary limitations apparent lack well dearth assessing efficacy compared control treatments. Although addressed current review, study incentivize assess disorders more fashion.
Язык: Английский
Процитировано
13
Journal of Eating Disorders, Год журнала: 2024, Номер 12(1)
Опубликована: Апрель 29, 2024
Abstract Background Anorexia nervosa has one of the highest mortality rates all mental illnesses. For those who survive, less than 70% fully recover, with many going on to develop a more severe and enduring phenotype. Research now suggests that genetics plays role in development persistence anorexia nervosa. Inclusion participants illness studies is critical. Objective The primary goal this review was assess inclusion meeting criteria for phenotype research by (1) identifying most widely used defining (2) performing literature identified criteria. Methods Searches from 2012 2023 were performed PubMed, PsycINFO, Web Science databases. Publications selected per Preferred Reporting Items Systematic Reviews Meta-Analyses extension Scoping (PRISMA-ScR). define derived how often they since 2017. publications through search then assessed these Results prevalent an duration ≥ 7 years, lack positive response at least two previous evidence-based treatments, body mass index Diagnostic Statistical Manual Mental Disorders-5 extreme nervosa, assessment psychological and/or behavioral severity indicating significant impact quality life. There consistent identification literature. Discussion This patients potential hamper isolation risk loci new, effective treatment options
Язык: Английский
Процитировано
2
Frontiers in Psychiatry, Год журнала: 2022, Номер 13
Опубликована: Май 11, 2022
Empirical evidence and clinical observations suggest a strong -yet under acknowledged-link between anorexia nervosa (AN) non-suicidal self-injurious behavior (NSSI). By reviewing the literature on psychopathology neurobiology of AN NSSI, we shed light their relationship. Both NSSI are characterized by disturbances in affect regulation, dysregulation reward circuitry opioid system. formulating reward-centered hypothesis, explain overlap NSSI. We propose three approaches understanding relationship which integrate from perspective self-destructiveness: (1) nosographical approach, (2) research domain (RDoC) approach (3) network analysis approach. These will enhance our knowledge underlying neurobiological substrates may provide groundwork for development new treatment options disorders self-destructiveness, like In conclusion, hypothesize that self-destructiveness is new, DSM-5-transcending concept or psychopathological entity reward-driven, both could be conceptualized as self-destructiveness.
Язык: Английский
Процитировано
10
Neurotherapeutics, Год журнала: 2024, Номер 21(3), С. e00366 - e00366
Опубликована: Апрель 1, 2024
Psychiatric disorders are among the leading contributors to global disease burden and disability. A significant portion of patients with psychiatric remain treatment-refractory best available therapy. With insights from neurocircuitry extensive experience neuromodulation deep brain stimulation (DBS) in movement disorders, DBS is increasingly being considered modulate neural network disorders. Currently, obsessive-compulsive disorder (OCD) only U.S. FDA (United States Food Drug Administration) approved indication for Medically refractory depression, addiction, other explored neuromodulation. Studies evaluating promising but lack larger, controlled studies. This paper presents a brief review current state neurosurgical therapies OCD We also present MR-guided Focused Ultrasound (MRgFUS), novel form neuromodulation, which can target subcortical structures similar DBS, noninvasive fashion. Early experiences therapies, including MRgFUS encouraging disorders; however, they investigational. VNS options properly selected cases respectively.
Язык: Английский
Процитировано
1
Journal of Eating Disorders, Год журнала: 2023, Номер 11(1)
Опубликована: Авг. 21, 2023
Anorexia nervosa (AN) is a severe and life-threatening psychiatric disorder. Initial studies on deep brain stimulation (DBS) in severe, treatment-refractory AN have shown clinical effects. However, the working mechanisms of DBS remain largely unknown. Here, we used task-based functional MRI approach to understand pathophysiology AN.We performed four patients that participated pilot study efficacy, safety, effects targeted at ventral limb capsula interna (vALIC). The six gender-matched healthy controls (HC) were investigated three different time points. We an adapted version monetary incentive delay task probe generic reward processing controls, food-specific only.At baseline, no significant differences for anticipation found between HC. Significant group (AN HC) by (pre- post-DBS) interactions right precuneus, putamen, medial orbitofrontal cortex (mOFC). No food viewing task, neither conditions high-calorie low-calorie images nor This could possibly be due small sample size lack control group.The results showed difference response reward-related areas post-DBS. supports hypotheses circuitry involved pathogenesis affects responsivity areas. Trial registration Registered Netherlands Register ( https://www.trialregister.nl/trial/3322 ): NL3322 (NTR3469).Anorexia Nervosa (An) eating disorder with many, sometimes life-threatening, complications. A substantial number do not respond available treatment options chronically ill or even die as consequence AN. Because part causes may reside brain, studied efficacy safety potential new option AN, namely (DBS). has proven effective movements disorders like Parkinson’s Disease other such obsessive compulsive Our previous research leads improvements weight, mood, anxiety, symptoms. In this substudy, examined specific circuitries are implicated conducted scans (fMRI) measure activity while tasks. observed when compared taken before after DBS, which our thoughts involvement parts
Язык: Английский
Процитировано
3
Heliyon, Год журнала: 2023, Номер 9(3), С. e14411 - e14411
Опубликована: Март 1, 2023
Hypothalamic dysfunction may result in morbid obesity as a consequence of decreased energy expenditure, feelings satiety, and increased fat storage. In patients with hypothalamic dysfunction, neurobehavioral is also often present. Currently, no effective treatment has been found for (HO). We hypothesize that deep brain stimulation (DBS) be an aiming to treat HO well the dysfunction.A systematic search was conducted PubMed, EMBASE Cochrane Library databases studies published until May 2022 reporting on DBS HO.Three met predetermined inclusion criteria, total six treated HO, which five Prader-Willi syndrome (PWS) one patient after craniopharyngioma (CP). Targets included lateral area (LHA) nucleus accumbens (NAcc). PWS, LHA-DBS associated mean increase Body Mass Index (BMI) (+5.8%), change hormonal levels, results blood workup, sleep, or neuropsychological evaluation. CP, NAcc-DBS decrease BMI (-8.7%) subjective mental health, willingness act, feeling appetite. No objective measurements function were reported. severe adverse events reported these cases. Mild moderate hypomanic symptoms infection. All described follow-up period (n = 5) able sustain at least 6 months few interruptions.There limited research HO. The effectiveness differed across evidence limited. Although there potential severe-refractory condition more needed target selection evaluation effectiveness.
Язык: Английский
Процитировано
2
BioMed Research International, Год журнала: 2022, Номер 2022, С. 1 - 13
Опубликована: Сен. 19, 2022
Ubiquitous technology, big data, more efficient electronic health records, and predictive analytics are now at the core of smart healthcare systems supported by artificial intelligence. In present narrative review, we focus on sensing technologies for Anorexia Nervosa (AN). We employed a framework inspired Interpersonal Neurobiology Theory (IPNB), which posits that human experience is characterized flow energy information both within us (within our whole body), between (in connections have with others nature). line this framework, focused sensors designed to evaluate bodily processes (body such as implantable sensors, epidermal wearable portable sensors), social interaction (sociometric physical environment (indoor outdoor ambient sensors). There myriad man-made well nature-based plants can be used design deploy intelligent monitoring healthcare. conclusion, smarter AN help relieve burden professionals. However, there technical, ethical, environmental sustainability issues must considered prior implementing these systems. A joint collaboration professionals other members society involved in individuals development The evolution cyberphysical should also collaborations.
Язык: Английский
Процитировано
3