Short bursts of transcutaneous auricular vagus nerve stimulation enhance evoked pupil dilation as a function of stimulation parameters

Cortex, Год журнала: 2022, Номер 159, С. 233 - 253

Опубликована: Дек. 17, 2022

Язык: Английский

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Transcutaneous auricular vagus nerve stimulation modulates the processing of interoceptive prediction error signals and their role in allostatic regulation

Human Brain Mapping, Год журнала: 2024, Номер 45(3)

Опубликована: Фев. 15, 2024

It has recently been suggested that predictive processing principles may apply to interoception, defined as the of hormonal, autonomic, visceral, and immunological signals. In current study, we aimed at providing empirical evidence for role cardiac interoceptive prediction errors signals on allostatic adjustments, using transcutaneous auricular vagus nerve stimulation (taVNS) a tool modulate afferents. within-subject design, participants performed cardiac-related task (heartbeat counting task) under taVNS sham stimulation, spaced 1-week apart. We observed taVNS, in contrast facilitated maintenance accuracy levels over time (from initial, stimulation-free, baseline block subsequent blocks), suggesting have helped maintain engagement afferent During task, compared sham, produced higher heart-evoked potentials (HEP) amplitudes, potential readout measure error processing. Further analyses revealed positive relation between adjustments-as measured by heart rate variability (HRV)-was mediated HEP amplitudes. Providing initial support accounts our results suggest increase precision with which are processed, favoring their influence adjustments.

Язык: Английский

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Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Фев. 27, 2024

Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.

Язык: Английский

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Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis

Brain stimulation, Год журнала: 2025, Номер 18(2), С. 148 - 157

Опубликована: Янв. 29, 2025

Язык: Английский

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Non‐Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load

Psychophysiology, Год журнала: 2025, Номер 62(2)

Опубликована: Фев. 1, 2025

ABSTRACT The vagus nerve is crucial in regulating physiological functions, including the cardiovascular system. While heart rate (HR) and its variability (HRV) may provide non‐invasive proxies of cardiac vagal activity, transcutaneous auricular stimulation (taVNS) has yielded mixed effects, with limited research on right branch stimulation. In a randomized crossover study 36 healthy participants, we investigated taVNS effects HR HRV indexed by SDRR, RMSSD, HF‐HRV, LF/HF ratio. To assess impact side (left vs. ear) indices interaction state, recorded electrocardiograms four sessions per person, covering three session phases: baseline, during (taVNS sham), post‐milkshake consumption First, found moderate evidence against affecting (BF 10 = 0.21). Second, decreased (multivariate p 0.004) independent strong for RMSSD 15.11) HF‐HRV 11.80). Third, taVNS‐induced changes were comparable across sides stronger than sham, indicating consistent side. We conclude that reduces as SDRR without altering HR, contradicting assumption se increases cardiovagal activity increased due to stimulating afferents. Instead, our results support role afferent activation arousal. Crucially, both can safely modulate system increasing risk bradycardia or causing adverse events offering new treatment possibilities.

Язык: Английский

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Phasic, Event-Related Transcutaneous Auricular Vagus Nerve Stimulation Modifies Behavioral, Pupillary, and Low-Frequency Oscillatory Power Responses

Journal of Neuroscience, Год журнала: 2023, Номер 43(36), С. 6306 - 6319

Опубликована: Авг. 17, 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) has been proposed to activate the locus ceruleus-noradrenaline (LC-NA) system. However, previous studies failed find consistent modulatory effects of taVNS on LC-NA biomarkers. Previous suggest that phasic may be capable modulating biomarkers such as pupil dilation and alpha oscillations. it is unclear whether these extend beyond pure sensory vagal responses. Critically, potential pupillary light reflex an additional biomarker not explored so far. Here, we applied active sham in 29 subjects (16 female, 13 male) while they performed emotional Stroop task (EST) a passive (PLRT). We recorded size brain activity dynamics using combined Magnetoencephalography (MEG) pupillometry design. Our results show significantly increased performance during EST. During PLRT, reduced delayed constriction. In MEG, frontal-midline theta power EST, whereas occipital was both EST PLRT. findings provide evidence systematically modulates behavioral, pupillary, electrophysiological parameters cognitive processing. Moreover, demonstrate for first time can used simple effective proxy efficacy. These have important implications development noninvasive neuromodulation interventions various clinical applications.SIGNIFICANCE STATEMENT gained increasing attention technique widely nonclinical research. Nevertheless, exact mechanism action yet fully understood. By assessing physiology behavior response conflict healthy humans, successful application phasic, improve control modulate markers noradrenergic Understanding mechanisms could optimize future applications lead better treatments mental disorders associated with dysfunction. addition, present new taVNS-sensitive measure representing easy-to-use studies.

Язык: Английский

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Short-term transcutaneous vagus nerve stimulation increases pupil size but does not affect EEG alpha power: A replication of Sharon et al. (2021, Journal of Neuroscience)

Brain stimulation, Год журнала: 2023, Номер 16(4), С. 1001 - 1008

Опубликована: Июнь 20, 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a potential treatment for pharmaco-resistant epilepsy and depression. Its clinical efficacy is thought to depend on taVNS-induced activation of the locus coeruleus other neuromodulator systems. However, unlike invasive VNS in rodents, there little evidence an effect taVNS noradrenergic activity.We attempted replicate recently published findings by Sharon et al. (2021), showing that short bursts transiently increased pupil size decreased EEG alpha power, two correlates central activity.Following original study, we used single-blind, sham-controlled, randomized cross-over design. Human volunteers (n = 29) received short-term (3.4 s) at maximum level below pain threshold, while collected resting-state pupil-size data. To analyze data, scripts provided colleagues.Consistent with dilation was significantly larger during than sham (p .009; Bayes factor supporting difference 7.45). failed power .37); data were four times more likely under null hypothesis (BF10 0.28).Our support effectiveness inducing transient dilation, correlate phasic activity. recent finding (2021) attenuates Overall, this study highlights need continued research neural mechanisms underlying its option conditions. It also direct replications influential studies.

Язык: Английский

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Transcutaneous Auricular Vagus Nerve Stimulation to Improve Emotional State

Biomedicines, Год журнала: 2024, Номер 12(2), С. 407 - 407

Опубликована: Фев. 9, 2024

Emotional experiences are a part of our lives. The maladaptive functioning an individual's emotional field can lead to disturbances various kinds, such as anxiety and depression. Currently, there is increasing prevalence disorders that cause great human suffering high socioeconomic costs. processing has biological basis. major neuroscientific theories emotion based on functioning, all them take into account the anatomy function tenth cranial nerve: vagus nerve. nerve connects subdiaphragmatic supradiaphragmatic areas modulates basis interoceptive functioning. Auricular stimulation new innovative neuromodulation technique Several interventions have shown this neurostimulation very promising resource for treating disorders. In paper, we summarise three emotion, explain what transcutaneous auricular is, present arguments its use continued research.

Язык: Английский

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Transcutaneous Auricular Vagus Nerve Stimulation Enhances Emotional Processing and Long‐Term Recognition Memory: Electrophysiological Evidence Across Two Studies

Psychophysiology, Год журнала: 2025, Номер 62(3)

Опубликована: Март 1, 2025

ABSTRACT Recently, we found that continuous transcutaneous auricular vagus nerve stimulation (taVNS) facilitates the encoding and later recollection of emotionally relevant information, as indicated by differences in late positive potential (LPP), memory performance, ERP Old/New effect. Here, aimed to conceptually replicate extend these findings investigating effects different time‐dependent taVNS protocols. In Study 1, an identical paradigm our previous study was employed with interval (30‐s on/off). Participants viewed unpleasant neutral scenes on two consecutive days while receiving or sham completed a recognition test 1 week later. Replicating results, images encoded under taVNS, compared stimulation, elicited larger amplitudes earlier window LPP during encoding, well more pronounced differences. However, no performance were found. 2, followed up synchronizing cycle image presentation determine for off cycles. We could enhancing brain potentials (early differences) improved recollection‐based both images, independently cycle. Overall, results suggest increases electrophysiological correlates emotional retrieval time‐independent manner, substantiating nerve's role processing formation, opening new venues improving mnemonic processes clinical non‐clinical populations.

Язык: Английский

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Auricular Transcutaneous Vagus Nerve Stimulation Specifically Enhances Working Memory Gate Closing Mechanism: A System Neurophysiological Study

Journal of Neuroscience, Год журнала: 2023, Номер 43(25), С. 4709 - 4724

Опубликована: Май 23, 2023

Everyday tasks and goal-directed behavior involve the maintenance continuous updating of information in working memory (WM). WM gating reflects switches between these two core states. Neurobiological considerations suggest that catecholaminergic GABAergic are likely involved dynamics. Both neurotransmitter systems underlie effects to auricular transcutaneous vagus nerve stimulation (atVNS). We examine atVNS on dynamics their underlying neurophysiological neurobiological processes a randomized crossover study design healthy humans both sexes. show specifically modulates gate closing thus neural mechanisms enabling WM. opening were not affected. through modulation EEG alpha band activity. This was case for clusters activity signal referring stimulus information, motor response fractions carrying stimulus-response mapping rules during closing. EEG-beamforming shows modulations fronto-polar, orbital, inferior parietal regions associated with effects. The data because (noradrenaline) system as indicated by lack modulatory pupil diameter dynamics, inter-relation saliva markers noradrenaline Considering other findings, it appears central effect cognitive processing refers stabilization circuits, putatively mediated via system.SIGNIFICANCE STATEMENT Goal-directed depends how well short-term can be flexibly updated but also shielded from distraction. These functions guarded gate. an increasingly popular brain techniques enhances ability close shield what physiological anatomic aspects

Язык: Английский

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