Neuromorphic hardware for somatosensory neuroprostheses

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 16, 2024

Abstract In individuals with sensory-motor impairments, missing limb functions can be restored using neuroprosthetic devices that directly interface the nervous system. However, restoring natural tactile experience through electrical neural stimulation requires complex encoding strategies. Indeed, they are presently limited in effectively conveying or sensations by bandwidth constraints. Neuromorphic technology, which mimics behavior of neurons and synapses, holds promise for replicating touch, potentially informing neurostimulation design. this perspective, we propose incorporating neuromorphic technologies into neuroprostheses could an effective approach developing more human-machine interfaces, leading to advancements device performance, acceptability, embeddability. We also highlight ongoing challenges required actions facilitate future integration these advanced technologies.

Язык: Английский

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Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 20, 2024

Abstract Artificial communication with the brain through peripheral nerve stimulation shows promising results in individuals sensorimotor deficits. However, these efforts lack an intuitive and natural sensory experience. In this study, we design test a biomimetic neurostimulation framework inspired by nature, capable of “writing” physiologically plausible information back into nervous system. Starting from in-silico model mechanoreceptors, develop policies. We then experimentally assess them alongside mechanical touch common linear neuromodulations. Neural responses resulting neuromodulation are consistently transmitted towards dorsal root ganglion spinal cord cats, their spatio-temporal neural dynamics resemble those naturally induced. implement paradigms within bionic device it patients (ClinicalTrials.gov identifier NCT03350061). He report that improves mobility (primary outcome) reduces mental effort (secondary compared to traditional approaches. The outcomes neuroscience-driven technology, human body, may serve as for advancing assistive neurotechnologies.

Язык: Английский

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Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation

Brain stimulation, Год журнала: 2024, Номер 17(2), С. 365 - 381

Опубликована: Март 1, 2024

Background:Intracortical microstimulation (ICMS) is used to map neuronal circuitry in the brain and restore lost sensory function, including vision, hearing, somatosensation. The temporal response of cortical neurons single pulse ICMS remarkably stereotyped comprises short latency excitation followed by prolonged inhibition and, some cases, rebound excitation. However, neural origin different components are poorly understood, interactions between three during trains pulses remains unclear.Objective:We computational modeling determine mechanisms contributing model neurons.Methods:We implemented a biophysically based column comprising with realistic morphology synapses quantified protocols. We characterized responses across stimulation intensities inhibitory (GABA-B/GABA-A) synaptic strengths. To probe components, we paired at inter-pulse intervals frequencies. Finally, evaluated performance biomimetic evoking sustained responses.Results:Single evoked period inhibition, but did not exhibit post-inhibitory strength increased duration amplitude. Prolonged resulted from both after-hyperpolarization currents GABA-B transmission. During protocol, test decreased marginally compared those for interpulse (IPI) < 100 ms. Further, was IPIs <50ms predicted linear superposition individual responses. For IPIs>50 ms, comparable pulse. Short repetitive excitatory against background inhibition. declined higher cessation frequencies following Biomimetic onset offset phases despite presence induced inhibition.Conclusions:The replicated long-lasting documented experimental studies ICMS. Both cellular influenced generated non-linear dynamic ICMS-evoked activity may play an important role mediating ICMS-induced precepts.

Язык: Английский

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Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation

Neuron, Год журнала: 2023, Номер 112(5), С. 821 - 834.e4

Опубликована: Дек. 21, 2023

Язык: Английский

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Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays

Journal of Neural Engineering, Год журнала: 2024, Номер 21(2), С. 026030 - 026030

Опубликована: Март 22, 2024

Abstract Objective . Over the past decade, neural electrodes have played a crucial role in bridging biological tissues with electronic and robotic devices. This study focuses on evaluating optimal tip profile insertion speed for effectively implanting Paradromics’ high-density fine microwire arrays (F μ A) prototypes into primary visual cortex (V1) of mice rats, addressing challenges associated ‘bed-of-nails’ effect tissue dimpling. Approach Tissue response was assessed by investigating impact blood-brain barrier (BBB) cellular damage, specific emphasis tailored strategies to minimize disruption during electrode implantation. Main results. Electro-sharpened demonstrated marked reduction damage within 50 m compared blunt angled arrays. Histological analysis revealed that slow speeds led greater BBB compromise than fast pneumatic methods. Successful single-unit recordings validated efficacy optimized electro-sharpened capturing activity. Significance. These findings underscore critical minimizing implantation, highlighting suitability long-term implant applications. research contributes deeper understanding complexities high-channel-count microelectrode array emphasizing importance meticulous assessment optimization key parameters effective integration minimal disruption. By elucidating interplay between response, our lays strong foundation development advanced implantable devices reactive gliosis improved performance recording

Язык: Английский

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Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

Journal of Neural Engineering, Год журнала: 2024, Номер 21(2), С. 026033 - 026033

Опубликована: Март 27, 2024

Abstract Objective . Intracortical microstimulation (ICMS) can be an effective method for restoring sensory perception in contemporary brain–machine interfaces. However, the mechanisms underlying better control of neuronal responses remain poorly understood, as well relationship between activity and other concomitant phenomena occurring around stimulation site. Approach Different frequencies were investigated vivo on Thy1-GCaMP6s mice using widefield two-photon imaging to evaluate evoked excitatory neural across multiple spatial scales induced hemodynamic responses. Specifically, we quantified stimulation-induced activation depression mouse visual cortex measured oxyhemoglobin deoxyhemoglobin signals mesoscopic-scale imaging. Main results Our calcium findings revealed a preference lower-frequency driving stronger activation. A depressive response following preferred slightly higher frequency compared Hemodynamic exhibited comparable spread signals. Oxyhemoglobin concentration site remained elevated during post-activation (depression) period. Somatic neuropil by microscopy showed similar dependence parameters, although magnitudes soma was greater than neuropil. Furthermore, higher-frequency more pronounced neuropil, while predominantly irrespective frequencies. Significance These suggest that mechanism differs from activation, requiring ample oxygen supply, affecting neurons. provide novel understanding ICMS offer insights into neuro-devices utilize both achieve desired

Язык: Английский

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Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

Abstract Neuromodulation technologies have gained considerable attention for their clinical potential in treating neurological disorders and advancing cognition research. However, traditional methods like electrical stimulation optogenetics face technical biological challenges that limit therapeutic research applications. A promising alternative, photoelectric neurostimulation, uses near‐infrared light to generate pulses thus enables of neuronal activity without genetic alterations. This study explores various design strategies enhance with minimally invasive, ultrasmall, untethered carbon electrodes. Employing a multiphoton laser as the (NIR) source, benchtop experiments are conducted using three‐electrode setup chronopotentiometry record photo‐stimulated voltage. In vivo evaluations utilize Thy1‐GCaMP6s mice acutely implanted ultrasmall Results highlighted beneficial effects high duty‐cycle scanning photovoltaic polymer interfaces on voltages by electrode. Additionally, carbon‐based diamond electrodes demonstrated application precise chemical delivery loading mesoporous silica nanoparticles (SNPs) co‐deposited polyethylenedioxythiophene (PEDOT). Together, these findings utilizing underscore its immense next generation neurostimulation technology.

Язык: Английский

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Rapid learning and integration of artificial sensation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

1 Summary Prosthetic limbs lack proprioceptive feedback, which is essential for complex movements. Intracortical mi-crostimulation (ICMS) elicits sensory perceptions that could serve as an artificial signal. However, movements guided by ICMS are slower and less accurate than those with natural sensation. Here, we developed a freely-moving mouse behavioral task to improve encoding of Mice implanted 16-channel microwire arrays in primary somatosensory cortex were trained navigate targets upon the floor custom training cage. Target location was encoded visual and/or feedback. quickly learned use signal locate invisible targets, achieving 75% proficiency on ICMS-only trials first three sessions testing. Furthermore, performance multimodal significantly exceeded unimodal performance, demonstrating animals integrated vision This protocol can be applied efficiently develop test algorithms encode proprioception neural prostheses.

Язык: Английский

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Biomimetic computer-to-brain communication restoring naturalistic touch sensations via peripheral nerve stimulation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 18, 2023

Abstract Artificial communication with the brain through peripheral nerve stimulation recently showed promising results in people sensorimotor deficits. However, these efforts fall short delivering close-to-natural rich sensory experience, resulting necessity to propose novel venues for converting information into neural patterns, which would possibly enable intuitive and natural sensations. To this aim, we designed tested a biomimetic neurostimulation framework inspired by nature, able “to write” physiologically plausible back residual healthy nervous system. Starting from in-silico model of mechanoreceptors, policies stimulation, emulating activity different afferent units. Then, experimentally assessed paradigms, alongside mechanical touch commonly used, linear neuromodulations. We explored somatosensory neuroaxis stimulating while recording responses at dorsal root ganglion spinal cord decerebrated cats. Biomimetic resulted that travels consistently along neuroaxis, producing spatio-temporal dynamic more like naturally evoked one. Finally, then implemented paradigms within bionic device it patients. neurostimulations higher mobility decreased mental effort compared traditional approaches. The neuroscience-driven technology human body could be development assistive neurotechnologies.

Язык: Английский

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Activation and depression of neural and hemodynamic responses induced by the intracortical microstimulation and visual stimulation in the mouse visual cortex

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

. Intracortical microstimulation can be an effective method for restoring sensory perception in contemporary brain-machine interfaces. However, the mechanisms underlying better control of neuronal responses remain poorly understood, as well relationship between activity and other concomitant phenomena occurring around stimulation site.

Язык: Английский

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