A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium

Clinical Neurophysiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The future of transcranial ultrasound as a precision brain interface

PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002884 - e3002884

Опубликована: Окт. 29, 2024

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.

Язык: Английский

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Low-intensity focused ultrasound for human neuromodulation

Nature Reviews Methods Primers, Год журнала: 2024, Номер 4(1)

Опубликована: Дек. 19, 2024

Язык: Английский

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Focused ultrasound as an emerging therapy for neuropsychiatric disease: Historical perspectives and a review of current clinical data

Psychiatry and Clinical Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Psychiatric disorders are a common source of disease morbidity with high rates refractoriness to first‐line treatments. As such, many have investigated the utility neurosurgical interventions for treatment‐resistant forms these conditions. More recently among these, functional techniques using high‐ and low‐intensity focused ultrasound (FUS) emerged as promising options in this arena, largely due their minimally‐invasive nature encouraging early safety efficacy data. Existing clinical data thus far demonstrated FUS be potentially useful intervention treatment‐refractory obsessive–compulsive disorder, major depressive various anxiety disorders, substance‐use schizophrenia. This report presents comprehensive review existing trial data, summarizing key findings, study specifications, providing critical analysis. In addition giving most complete summary modern research on topic date, characterizes current state body literature bibliometric analysis, succinctly highlighting topics areas investigation. Based our literature, work is highly heterogeneous regard specific treatment protocols anatomic targets – targeting multiple nuclei at wide variety intensities. We recommend that future studies aim clarify more precise therapeutic which optimize techniques.

Язык: Английский

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Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment

Brain and Neuroscience Advances, Год журнала: 2025, Номер 9

Опубликована: Март 1, 2025

Mental disorders pose a significant global burden and constitute major cause of disability worldwide. Despite strides in treatment, substantial number patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy specificity. Variations mechanistic understanding reliability among methods are common, limited spatial precision physical constraints hindering ability to target subcortical areas often implicated disease aetiology. Novel such as transcranial ultrasonic temporal interference have gained notable momentum recent years, possibly addressing these shortcomings. Transcranial (TUS) offers exceptional deeper penetration compared conventional electrical magnetic techniques. Studies targeting diverse array regions shown its potential affect neuronal excitability, functional connectivity symptoms psychiatric depressive disorder. Nevertheless, planning acoustic interactions skull must be tackled widespread adoption research potentially clinical settings. Similar stimulation, (TI) traditional albeit requiring comparatively higher current equivalent neural effects. Promising still sparse highlights TI’s selectively modulate activity, showing utility psychiatry. Overall, like only open new avenues but also hold effective treatments However, realising their full necessitates practical optimising application effectively.

Язык: Английский

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Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by oaering unparalleled spatial precision and flexible targeting capabilities. However, peripheral confounds pose a significant challenge to reliably implementing this technology. While auditory during TUS have been studied extensively, the somatosensory confound has overlooked thus far. It will become increasingly vital quantify manage as field shifts towards higher doses, more compact devices, frequent through temple where co-stimulation pronounced. Here, we provide systematic characterisation of TUS. We also identify conditions under which can be mitigated most eaectively mapping confound-parameter space. Specifically, investigate dose-response eaects, pulse shaping characteristics, transducer-specific parameters. demonstrate that avoiding near-field intensity peaks in scalp, spreading energy across greater area ramping envelope, delivering equivalent doses via longer, lower-intensity pulses rather than shorter, higher-intensity pulses. Additionally, repetition frequencies fundamental reduce eaects. Through our parameter space, find preliminary evidence particle displacement (strain) may primary biophysical driving force behind co-stimulation. This study provides actionable strategies minimise confounds, support thorough experimental control required unlock full potential for scientific research clinical interventions. Tactile, thermal, even painful occur TUS.Confounds & parameters.Valid replicable requires confounds.Particle confounds.

Язык: Английский

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Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats

Neuropsychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 19, 2025

Abstract Subanesthetic ketamine is currently used as a rapid-acting treatment for varied neuropsychiatric disorders. However, the mechanistic underpinnings of its therapeutic action remain unclear, and emerging clinical preclinical evidence highlights potential involvement opioid system. We pharmacological functional ultrasound imaging data acquired during after administration in male female rats pretreated with naltrexone, an receptor antagonist, or vehicle. found that ketamine-induced connectivity changes are modulated by blockade, these responses dependent on biological sex. Specifically, naltrexone sex-dependently altered patterns within medial prefrontal cortex (mPFC), key node brain’s default-mode network, between mPFC other nodes. Furthermore, produced opioid-dependent shift toward states increased dysconnectivity brain entropy only. Our findings warrant further investigation into neurophysiological sex-specific interactions receptors.

Язык: Английский

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Neurotechnology for enhancing human operation of robotic and semi-autonomous systems

Frontiers in Robotics and AI, Год журнала: 2025, Номер 12

Опубликована: Май 23, 2025

Human operators of remote and semi-autonomous systems must have a high level executive function to safely efficiently conduct operations. These face unique cognitive challenges when monitoring controlling robotic machines, such as vehicles, drones, construction equipment. The development safe experienced human machines requires structured training credentialing programs. This review critically evaluates the potential for incorporating neurotechnology into operator work enhance human-machine interactions, performance, safety. Recent evidence demonstrating that different noninvasive neuromodulation neurofeedback methods can improve critical functions attention, learning, memory, control is reviewed. We further describe how these approaches be used outcomes, well teleoperator vigilance decision-making. also help during complex or high-risk tasks by mitigating impulsive decision-making errors. While our advocates programs, continued research required evaluate will impact industrial safety workforce readiness.

Язык: Английский

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Magnitude preparation‐based MR‐acoustic radiation force imaging

Magnetic Resonance in Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Abstract Purpose To visualize ultrasonic foci in tissue without phase subtraction, to reduce sensitivity motion and respiration. A secondary purpose is provide inherently fused anatomy focus depiction across various image contrasts. Methods magnitude‐contrast MR‐acoustic radiation force imaging (Mag‐ARFI) magnetization‐preparation sequence was implemented that converts displacement‐induced shifts into modulated longitudinal magnetization can be read out by a subsequent sequence. Phantom experiments compared visualization between conventional contrast‐ARFI Mag‐ARFI, demonstrated the ability quantify displacement using multiple Mag‐ARFI measurements. In vivo maps ‐ ‐weighted images were acquired loop coil pulsed with DC mimic an ultrasound focus‐induced shift. Breathing artifacts head phase‐contrast MR‐ARFI methods. Results strong agreement (R = 0.88) values. ARFI peak displacements 3.02 m 3.91 m, respectively. FWHM [9.45, 10.35] mm, of [7.65, 8.56] mm. Head showed background anatomy, correlating well 0.87 for T 1 ‐weighted, R 0.79 2 ‐weighted). had reduced breathing artifacts, 3.5 lower coefficient variation than contrast‐ARFI. Conclusion allows localization, on magnitude containing anatomical details.

Язык: Английский

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Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Ноя. 29, 2024

Opioid use disorder (OUD) is a serious and persistent problem in the United States with limited non-pharmacological treatment options, especially for concomitant sleep disorders experienced by most individuals addiction. While new, non-invasive interventions such as low-intensity focused ultrasound (LIFU) have shown promise targeting brain regions impacted throughout addiction recovery, devices used are not amenable to outpatient their current form factor cannot be at night during sleep. To bridge this gap provide much-needed option repeated, at-home use, we developed wearable LIFU device out-of-clinic use.

Язык: Английский

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