Methods, Год журнала: 2023, Номер 220, С. 38 - 54
Опубликована: Окт. 25, 2023
Язык: Английский
Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)
Опубликована: Июнь 14, 2024
Abstract Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly peptides specifically those nearing succinct 100 amino acids. At forefront epiphany stand lncRNAs and circRNAs, distinctively characterized embedded small open reading frames (sORFs). Increasing evidence has revealed different functions mechanisms peptides/proteins encoded in cancer, including promotion inhibition cancer cell proliferation, cellular metabolism (glucose lipid metabolism), concerted metastasis cells. The discoveries not only accentuate depth ncRNA functionality but also novel avenues for oncological research therapeutic innovations. main difficulties study these ncRNA-derived hinge crucially on precise peptide detection sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, dedicated databases tailored unearthing In addition, conclude potential clinical applications therapy.
Язык: Английский
Процитировано
5
Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)
Опубликована: Фев. 19, 2025
In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.
Язык: Английский
Процитировано
0
Clinical Cancer Research, Год журнала: 2023, Номер 29(12), С. 2173 - 2175
Опубликована: Апрель 11, 2023
Summary The authors of a recent study identified noncanonical peptides (NCP) presented by cancer cells’ HLA and observed lack reactivity to these antigens endogenous tumor-reactive T cells. In vitro sensitization generated NCP-reactive cells that recognized epitopes shared majority cancers tested, providing opportunities for novel therapies antigens. See related article Lozano-Rabella et al., p. 2250
Язык: Английский
Процитировано
9
Cancer Letters, Год журнала: 2024, Номер 587, С. 216691 - 216691
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
2
Non-coding RNA Research, Год журнала: 2024, Номер 10, С. 231 - 241
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
2
Nucleic Acids Research, Год журнала: 2024, Номер 53(1)
Опубликована: Дек. 23, 2024
Abstract Recent studies have confirmed that certain circRNAs encode proteins are integral to various biological functions. In this study, we present CICADA, an algorithm specifically designed assess the protein-coding potential and coding products of at high throughput, which enables identification previously unknown circRNA-encoded proteins. By harnessing algorithm, identified a variety functional, in esophageal squamous cell carcinoma established circRNA translation profiles for diverse types cancer. This advancement innovatively explores hidden proteome within genome, poised catalyze discoveries biomarkers therapies cancers complex diseases. CICADA is accessible as Python module (https://github.com/SunLab-biotool/CICADA).
Язык: Английский
Процитировано
2
Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155037 - 155037
Опубликована: Дек. 13, 2023
Язык: Английский
Процитировано
4
Non-coding RNA Research, Год журнала: 2024, Номер 9(3), С. 964 - 969
Опубликована: Апрель 25, 2024
Long noncoding RNAs (lncRNAs) are a group of transcripts longer than 200 nucleotides, which play important roles in regulating various cellular activities by the action RNA itself. However, about 40 % lncRNAs human cells potentially translated into micropeptides (also referred to as microproteins) usually shorter 100 amino acids. Thus, these may function both directly and their encoded micropeptides. The regulate transcription, translation, protein phosphorylation or degradation, subcellular membrane functions. This review attempts summarize biochemical targets micropeptides-encoded lncRNAs, micropeptides, discuss associations with diseases potentials drug targets.
Язык: Английский
Процитировано
1
Computers in Biology and Medicine, Год журнала: 2024, Номер 177, С. 108660 - 108660
Опубликована: Май 27, 2024
Язык: Английский
Процитировано
1
Опубликована: Июнь 28, 2024
Cancer develops from abnormal cell growth in the body, causing significant mortalities every year. To date, potent therapeutic approaches have been developed to eradicate tumor cells, but intolerable toxicity and drug resistance can occur treated patients, limiting efficiency of existing treatment strategies. Therefore, searching for novel genes critical cancer progression response is urgently needed successful therapy. Recent advances bioinformatic proteomic techniques allowed identification a category peptides encoded by non-canonical open reading frames (ncORFs) historically non-coding genomic regions. Surprisingly, many ncORFs express functional microproteins that play vital role human cancers. In this review, we provide comprehensive description different ncORF types with coding capacity technological methods discovering among genomes. We also summarize diagnostic prognostic value these as well their carcinogenic underestimated potential targets.
Язык: Английский
Процитировано
1