Cancer Letters, Год журнала: 2024, Номер unknown, С. 217388 - 217388
Опубликована: Дек. 1, 2024
Язык: Английский
Communications Biology, Год журнала: 2024, Номер 7(1)
Опубликована: Апрель 2, 2024
Abstract The occurrence of chemoresistance is an inescapable obstacle affecting the clinical efficacy cisplatin in gastric cancer (GC). Exploring regulatory mechanism resistance will help to provide potential effective targets for improving prognosis patients. Here, we find that FAM120A upregulated GC tissues and higher cisplatin-resistant tissues, its high expression positively correlated with poor outcome Functional studies indicate confers cells by inhibiting ferroptosis. Mechanically, METTL3-induced m6A modification YTHDC1-induced stability mRNA enhance expression. inhibits ferroptosis binding SLC7A11 enhancing stability. deficiency enhances sensitivity promoting vivo. These results reveal function chemotherapy tolerance targeting strategy alleviate GC.
Язык: Английский
Процитировано
7
Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Programmed cell death is pivotal for several physiological processes, including immune defense. Further, it has been implicated in the pathogenesis of developmental disorders and onset numerous diseases. Multiple modes programmed death, apoptosis, pyroptosis, necroptosis, ferroptosis, have identified, each with their own unique characteristics biological implications. In February 2023, Liu Xiaoguang his team discovered "disulfidptosis," a novel pathway death. Their findings demonstrated that disulfidptosis triggered glucose-starved cells exhibiting high expression protein called SLC7A11. Furthermore, marked by drastic imbalance NADPH/NADP+ ratio abnormal accumulation disulfides like cystine. These changes ultimately lead to destabilization F-actin network, causing Given SLC7A11 key feature certain cancers, these indicate could serve as basis innovative anti-cancer therapies. Hence, this review delves into discovery disulfidptosis, its underlying molecular mechanisms metabolic regulation, prospective applications disease treatment.
Язык: Английский
Процитировано
6
Methods in molecular biology, Год журнала: 2023, Номер unknown, С. 61 - 72
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
14
Aging, Год журнала: 2023, Номер 15(22), С. 12952 - 12965
Опубликована: Ноя. 16, 2023
Colorectal cancer is one of the most common malignant tumors in digestive system, and its high incidence metastasis rate make it a terrible killer that threatens human health. In-depth exploration targets affecting progression colorectal cells development specific targeted drugs for them are great significance prognosis patients. Erythropoietin-producing hepatocellular A2 (EphA2) member Eph subfamily with tyrosine kinase activity, plays key role regulation signaling pathways related to phenotype various tumor cells, but regulatory mechanism needs be further clarified. Here, we found EphA2 was abnormally highly expressed patients expression had worse prognosis. We also can form liquid-liquid phase separation condensates on cell membrane, which disrupted by ALW-II-41-27, an inhibitor EphA2. In addition, positively correlated ferroptosis-related genes infiltration multiple immune cells. These findings suggest novel membrane protein ability associated ferroptosis infiltration, suggests may inhibited suppressing
Язык: Английский
Процитировано
12
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Фев. 20, 2025
Gastric cancer (GC) remains one of the most common types cancer, ranking fifth among cancer-related deaths worldwide. Chemotherapy is an effective treatment for advanced GC. However, development chemotherapy resistance, which involves malfunction several signaling pathways and consequence numerous variables interacting, seriously affects patient leads to poor clinical outcomes. Therefore, in order treat GC, it imperative find novel medications that will increase sensitivity reverse resistance. Traditional Chinese medicine (TCM) has been extensively researched as adjuvant medication recent years. It shown have anticancer benefits be crucial enhancing reducing Given this, mechanism resistance GC summed up this work. The theoretical foundation TCM a sensitizer established by introducing primary signal possible targets implicated improving reversing active ingredients.
Язык: Английский
Процитировано
0
Biomarker Research, Год журнала: 2025, Номер 13(1)
Опубликована: Фев. 26, 2025
Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.
Язык: Английский
Процитировано
0
Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 11, 2025
Gastric cancer (GC) is a deadly disease with poor prognosis and few treatment options. Tropomyosin 4 (TPM4) an actin-binding protein that stabilizes the cytoskeleton of cells has unclear role in GC. This study aimed to elucidate underlying mechanisms TPM4 GC pathogenesis. The expression diagnostic prognostic value were analyzed using bioinformatics. A nomogram based on was created validated external cohort. TPM4-knockdown xenograft models nude mice used function vitro vivo. Proteomic rescue experiments confirmed regulatory effect stearoyl-CoA desaturase 1 (SCD1) Immunohistochemistry verified correlation SCD1 proteins tissues. Our identified as oncogene GC, suggesting its potential value. TPM4-based showed for clinical use. knockdown inhibited cell proliferation, induced ferroptosis, slowed tumor growth vivo, which achieved by inhibiting expression. Immunohistochemical analysis tissues revealed elevated levels both proteins, positive observed between their promising target new diagnostic, prognostic, therapeutic strategies Downregulation inhibits induces ferroptosis suppressing
Язык: Английский
Процитировано
0
Cell Death and Disease, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 12, 2025
MSL1, a scaffold protein of the MSL histone acetyltransferase complex, is crucial for its structural integrity and enzymatic activity. While MSL1 highly expressed in various tumors, role tumor progression cell death remains unclear. Here, we provide evidence negative regulatory relationship between KCTD12 through biochemical assays knockdown/overexpression studies. Notably, colon cancer cells, ferroptosis inducer Erastin significantly suppressed expression, leading to upregulation. Moreover, promotes Erastin-induced HCT116 SW480 cells via KCTD12-SLC7A11 axis. Consistently, changes ROS, GSH, MDA levels were regulated by this axis, highlighting ferroptosis. These findings offer potential therapeutic targets theoretical foundation treatment.
Язык: Английский
Процитировано
0
Cell Death and Differentiation, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
3
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(6), С. 2335 - 2349
Опубликована: Июнь 14, 2024
As a highly aggressive tumor, the pathophysiological mechanism of primary liver cancer has attracted much attention. In recent years, factors such as ferroptosis regulation, lipid peroxidation and metabolic abnormalities have emerged in study cancer, providing new perspective for understanding development cancer. Ferroptosis play important roles occurrence The regulation is involved apoptosis necrosis, affecting cell survival death. Lipid promotes oxidative damage invasion cells. Metabolic abnormalities, especially disorders glucose metabolism, directly affect proliferation growth Studies may help to discover therapeutic targets improve outcomes. can provide ideas prevention reduce risk disease by adjusting process. This review focuses on key this
Язык: Английский
Процитировано
2