Опубликована: Янв. 1, 2024
Язык: Английский
iScience, Год журнала: 2024, Номер 27(4), С. 109350 - 109350
Опубликована: Фев. 27, 2024
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality, with metastasis being primary determinant poor prognosis in patients. Investigating molecular mechanisms underlying CRC is currently a prominent and challenging area research. Exosomes, crucial intercellular communication mediators, facilitate transfer metabolic genetic information from cells origin to recipient cells. Their roles mediating exchange between immune cells, fibroblasts, other cell types are pivotal reshaping tumor microenvironment, regulating key biological processes such invasion, migration, formation pre-metastatic niche. This article comprehensively examines function mechanism exosomes derived different metastasis, while also presenting an outlook on current research advancements future application prospects. The aim offer distinctive perspective that contributes accurate diagnosis rational treatment strategies for CRC.
Язык: Английский
Процитировано
9
Cancer Letters, Год журнала: 2024, Номер 587, С. 216723 - 216723
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
8
Clinica Chimica Acta, Год журнала: 2024, Номер 556, С. 117849 - 117849
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
7
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 4279 - 4295
Опубликована: Май 1, 2024
Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are type of cell that only found inside the nervous system. These can differentiate into various kinds cells, potentially regenerating or restoring neural networks within areas brain have been destroyed. This review begins by providing introduction existing approaches for ischemic followed examination promise limits associated with utilization NSCs treatment stroke. Subsequently, comprehensive overview was conducted synthesize literature on underlying processes cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy context mechanisms encompass neuroprotection, inflammatory response suppression, endogenous nerve vascular regeneration facilitation. Nevertheless, translation NSC-sEVs is hindered challenges such as inadequate targeting efficacy insufficient content loading. In light these limitations, we compiled advancements utilizing modified treating stroke based methods vesicle modification. conclusion, examining NSC-sEVs-based anticipated be both fundamental applied investigations about
Язык: Английский
Процитировано
4
Cell & Bioscience, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 3, 2024
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, characterized by difficulties in early diagnosis, prone to distant metastasis, and high recurrence rates following surgery. Extracellular vesicles (EVs) are a class cell-derived particles, including exosomes, phospholipid bilayer. They serve as effective carriers for intercellular communication cargo, proteins nucleic acids, widely involved tumor progression. being explored potential biomarkers novel therapeutic avenues. We provide brief overview biogenesis characteristics EVs better understand their classification standards. The focus this review on research progress EV-associated field HCC. growth regulation HCC, participate within microenvironment (TME), implicated events angiogenesis epithelial-mesenchymal transition (EMT) during metastasis. In addition, show promising diagnostic efficacy For treatment they also demonstrate significant enhancing vaccines, targeting cargo anchors. Facing current challenges, we propose future directions field. Above all, offers enhance our comprehension HCC offer insights developing new strategies.
Язык: Английский
Процитировано
4
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 298, С. 139443 - 139443
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0
Extracellular Vesicles and Circulating Nucleic Acids, Год журнала: 2025, Номер 6(1), С. 112 - 27
Опубликована: Фев. 24, 2025
The role of extracellular vesicles (EVs) in mediating chemoresistance has gained significant attention due to their ability transfer bioactive molecules between drug-resistant and drug-sensitive cells. In particular, they have been demonstrated play an active part breast cancer by the horizontal genetic protein material. This review highlights EVs, particularly miRNA cargo, driving drug resistance cancer. EVs derived from chemoresistant cells carry miRNAs lncRNAs, which are known modulate gene networks involved cell proliferation survival. These cargo suppress apoptosis targeting pro-apoptotic genes like PTEN BIM, promote epithelial-mesenchymal transition (EMT) through regulation pathways such as TGF-β Wnt/b-catenin, contribute tumor growth enhancing angiogenesis modulating microenvironment. Beyond RNA-mediated effects, also functional proteins, including P-glycoprotein Hsp70, impact cellular metabolism survival pathways. Our findings underscore significance chemoresistance, suggesting potential involvement possible prognostic factors predict therapy response therapeutic targets combination with usual therapy.
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер 617, С. 217596 - 217596
Опубликована: Март 12, 2025
M2 macrophages play a critical role in the tumor microenvironment of invasive solid tumors. They are closely associated with perineural invasion (PNI) and often linked to poor prognosis. In this context, tumor-derived exosomes serve as important mediators intercellular communication. However, relationship between cell-induced PNI cholangiocarcinoma remains unexplored. study, we utilized multiplex immunofluorescence transcriptomic sequencing demonstrate upregulation LINC01812 tissues its positive correlation macrophage infiltration. Exosomal lncRNA sequencing, exosome uptake experiments, RNA pull-down assays, mass spectrometry analysis demonstrated that can internalize exosomal promote phenotype cells. Additionally, Transwell vitro cocultures dorsal root ganglia confirmed significantly enhances nerve infiltration cells via macrophages. The findings study indicate containing derived from induce polarization facilitate infiltration, thereby providing new potential therapeutic targets for managing cholangiocarcinoma.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2880 - 2880
Опубликована: Март 22, 2025
Small extracellular vesicles (sEVs) play a crucial role in intercellular communication and have demonstrated significant relevance reproductive biotechnology, particularly vitro maturation (IVM) bovine embryo production. This study evaluates the effects of follicular fluid-derived (ffsEVs) isolated using two methods: ultracentrifugation (UC) size-exclusion chromatography (SEC) on oocyte preimplantational embryonic development. Significant differences size ffsEVs obtained by both isolation methods were noted, with UC-derived (UC ffsEVs) being smaller than those SEC (SEC ffsEVs). UC more effective upregulating critical quality genes, such as HSF1 CPT1B. However, no observed developmental rates. Furthermore, expression genes associated revealed that only group exhibited increase IFNT1 SOX2 levels, indicating an enhancement quality. Notably, blastocysts derived from also showed higher total cell count compared to ffsEVs. No found other like GLUT1 CDX2. These results suggest use could improve production process, highlighting importance method determining functional efficacy according research objectives.
Язык: Английский
Процитировано
0
Oncogene, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
ncRNAs encapsulated in small extracellular vesicles (sEVs) facilitate intercellular communication and are associated with tumor progression. lncRNA-HOTAIRM1 is aberrantly expressed various cancers. However, HOTAIRM1 expression its downstream ceRNA network CTCL remains unclear. In this study, we found that was reduced CTCL. Elevated inhibited proliferation induced apoptosis vitro, resulting vivo tumorigenic capacity. Whole-transcriptome sequencing scRNA-Seq confirmed differential of HOTAIRM1/miR-196b-5p/MGAT4A axis induces resistance Mechanistically, MGAT4A leads to decreased N-glycosylation modification membrane proteins Galectin-1 affinity, thereby inducing partial Galectin-1-induced apoptosis. Meanwhile, benign CD4 + T cells show sensitivity due their relatively higher expression. Furthermore, MGAT4ALow transformed MGAT4AHigh CD4+ into by secreting sEVs containing miR-196b-5p, reducing binding resistance. Engineered from HOTAIRM1-overexpressing contain elevated HOTAIRM1, which can specifically target malignant cells, miR-196b-5p increased MGAT4A, demonstrating apoptosis-inducing tumor-suppressive effects This study identified changes modifications HOTAIRM1-loaded demonstrated promising targeting therapeutic
Язык: Английский
Процитировано
0