Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Cervical
cancer
(CC)
is
a
serious
risk
to
women's
health;
it
necessary
explore
less
toxic
and
more
effective
therapies
cure
CC.
Triptolide
(Tri)
the
principal
active
constituent
found
in
"Tripterygium
Wilford,"
has
been
shown
have
antitumor
effects.
This
study
set
up
demonstrate
whether
Tri
capable
of
inducing
ferroptosis
CC
cells
its
potential
mechanism.
In
vitro,
was
used
treat
cells,
lipid
peroxidation
levels
were
detected
by
flow
cytometry,
immunofluorescence,
other
experiments;
molecular
mechanism
treatment
explored
western
blot;
moreover,
regulatory
effects
on
NRF2/GPX4/xCT
axis
verified
overexpressing
NRF2
reverse.
vivo,
tumor-bearing
mice
constructed
observe
effect
tumor
growth.
we
demonstrated
that
prevents
growth
migration
cells.
Further
investigation
revealed
substantially
enhances
increasing
accumulation.
Mechanically,
significantly
reduced
expression
NRF2,
leading
corresponding
repression
downstream
targets
GPX4
xCT.
Moreover,
effectively
reversed
impact
Additionally,
animal
experiments
indicted
markedly
inhibited
size
nude
inhibiting
axis.
exerts
triggering
through
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Abstract
Colorectal
cancer
(CRC)
ranks
among
the
leading
causes
of
cancer‐related
dea
ths
worldwide,
and
rising
incidence
mortality
CRC
underscores
urgent
need
for
better
understanding
management
strategies.
Icaritin
(ICA)
is
metabolites
icariin,
a
natural
flavonoid
glycoside
compound
derived
from
stems
leaves
Epimedium
.
It
has
broad
spectrum
antitumor
activity
inhibits
proliferation,
migration,
invasion
cells,
S
phase
cell
cycle
arrest.
exerts
its
effects
against
through
repressing
autophagy
to
promote
apoptosis
via
interfering
HSP90‐TXNDC9
interactions.
The
safety
efficacy
ICA
are
also
affirmed
in
mouse
xenograft
model.
Additionally,
test
whether
synergistic
with
low‐temperature
photothermal
therapy
(LTPTT),
novel
nanodrug
delivery
system,
employing
SiO
2
nanocarriers,
designed
aiming
load
materials
polydopamine
(PDA),
folic
acid
(FA).
This
/Ica‐PDA‐FA
multifunctional
nanocomposite
actively
targets
tumor
tissues
high
affinity
FA
cells.
Once
internalized,
acidic
intracellular
environment
triggers
controlled
release
ICA,
inhibiting
By
LTPTT
drug
under
near‐infrared
illumination,
dual
effect
achieved,
holding
promise
enhancing
therapeutic
outcomes
treatment.
Biology,
Год журнала:
2025,
Номер
14(1), С. 61 - 61
Опубликована: Янв. 13, 2025
miRNAs
are
small
non-coding
RNA
molecules
that
play
critical
roles
in
the
regulation
of
gene
expression
and
have
been
closely
associated
with
various
diseases,
including
cancer.
These
significantly
influence
cell
cycle
tumor
cells
control
programmed
death
(apoptosis).
Currently,
research
on
has
become
a
major
focus
developing
cancer
therapies.
Osteosarcoma,
malignant
neoplasm
predominantly
occurring
during
adolescence
later
life,
is
characterized
by
high
propensity
for
metastasis.
This
review
explores
role
initiation
progression
cancer,
highlighting
their
potential
as
predictive
biomarkers
disease.
It
discusses
mechanisms
which
natural
products
modulate
miRNA
activity
to
apoptosis,
ferroptosis,
autophagy
osteosarcoma
cells,
aiming
identify
new
strategies
treatment.
Recent
studies
how
regulate
reduce
resistance
chemotherapy
also
reviewed.
Furthermore,
elaborates
m6A
modifications
expression,
thereby
exerting
antitumor
effects.
In
this
process,
interactions
between
identified,
both
jointly
influencing
tumorigenesis
progression,
offering
perspective
approaches
could
help
uncover
novel
regulatory
pathways
provide
theoretical
foundation
drugs
identifying
therapeutic
targets.
Cellular and Molecular Life Sciences,
Год журнала:
2025,
Номер
82(1)
Опубликована: Янв. 29, 2025
Pancreatic
β-cell
damage
is
a
critical
pathological
mechanism
in
the
progression
of
obese
type
2
diabetes
mellitus
(T2DM).
However,
exact
underlying
remains
unclear.
We
established
an
T2DM
mouse
model
via
high-fat
diet
feeding.
The
protein
expression
profiles
pancreatic
tissues
from
normal
and
mice
were
analyzed,
revealing
that
nuclear
factor
activated
T
cells
5
(NFAT5)
ferroptosis
are
potential
mediators
mechanisms
mice.
In
vitro,
high
glucose
palmitate
treatment
resulted
increased
NFAT5
translocation
MIN6
cells.
Inhibition
by
shRNA
significantly
reduced
improved
reduction
insulin
secretion
palmitic
acid
(PG)-treated
Luciferase
reporter
chromatin
immunoprecipitation
(ChIP)
assays
confirmed
ability
to
bind
peroxiredoxin
(PRDX2)
promoter,
leading
downregulation
PRDX2
transcription.
Subsequent
rescue
experiments
involved
PG-induced
inhibiting
PRDX2.
Finally,
we
demonstrated
use
AAV8-RIP2-miR30-shNFAT5
vector
specifically
inhibit
β-cells
diminishes
mice,
thereby
increasing
improving
abnormal
tolerance.
These
findings
collectively
highlight
therapeutic
targeting
β
counteract
obesity-induced
T2DM.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 18, 2025
Gastric
cancer
(GC)
is
a
prevalent
malignant
tumor
that
originates
from
the
epithelial
cells
of
gastric
mucosa,
predominantly
in
form
adenocarcinoma.
Extensive
research
has
confirmed
significant
role
autophagy
initiation,
progression,
and
chemoresistance
GC.
The
potential
traditional
Chinese
medicine
(TCM)
to
exert
anti-tumor
effects
by
modulating
been
demonstrated,
particularly
context
GC
prevention
treatment.
Natural
products
(NPs)
have
great
therapeutic
treatment
targeting
autophagy-related
genes
signaling
pathways
intervene
biological
behaviors
such
as
proliferation,
metastasis,
invasion
death.
This
article
describes
molecular
mechanisms
key
markers
autophagy,
involved
GC-associated
(PI3K/AKT/mTOR,
AMPK,
MAPK,
p53),
summarizes
mechanism
Helicobacter
pylori
infection
GC,
how
interacts
with
apoptotic
iron-death
processes
wide-ranging
influences
these
factors
play
process.
Finally,
this
paper
systematically
natural
compounds
terpenoids,
polyphenols,
alkaloids,
saponins,
polysaccharides
modulate
targets
for
evaluates
toxic
NPs,
providing
more
compelling
rationale
direction
therapy.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 258 - 258
Опубликована: Фев. 24, 2025
Oxidative
stress,
which
is
characterized
by
an
imbalance
between
reactive
oxygen
species
(ROS)
production
and
antioxidant
defenses,
has
critical
roles
in
the
initiation,
progression,
treatment
of
gastric
cancer.
On
one
hand,
excessive
ROS
accumulation
induces
oxidative
damage
cancer
cell
death.
other
moderate
levels
cause
genetic
mutations
dysregulation
signaling
pathways
to
promote
proliferation,
inflammation,
angiogenesis,
metastasis
Notably,
emerging
evidence
revealed
that
also
mediate
post-translational
modifications
(oxPTMs)
redox-sensitive
proteins,
can
directly
affect
protein
functions
regulate
redox
cells.
Therefore,
elucidating
regulatory
mechanisms
stress
holds
great
promise
identify
novel
therapeutic
targets
or
redox-targeting
strategies.
This
review
will
summarize
regulating
hallmarks
highlight
ROS-mediated
oxPTMs
In
addition,
we
discuss
strategies
targeting
for
cancer,
with
emphasis
on
use
bioactive
natural
products
nanomaterials.
