ROS: A “booster” for chronic inflammation and tumor metastasis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(6), С. 189175 - 189175
Опубликована: Авг. 31, 2024
Язык: Английский
Precision Targeting Strategies in Pancreatic Cancer: The Role of Tumor Microenvironment
Cancers,
Год журнала:
2024,
Номер
16(16), С. 2876 - 2876
Опубликована: Авг. 19, 2024
Pancreatic
cancer
demonstrates
an
ever-increasing
incidence
over
the
last
years
and
represents
one
of
top
causes
cancer-associated
mortality.
Cells
tumor
microenvironment
(TME)
interact
with
cells
in
pancreatic
ductal
adenocarcinoma
(PDAC)
tumors
to
preserve
cells'
metabolism,
inhibit
drug
delivery,
enhance
immune
suppression
mechanisms
finally
develop
resistance
chemotherapy
immunotherapy.
New
strategies
target
TME
genetic
alterations
specific
pathways
cell
populations
TME.
Complex
molecular
interactions
between
PDAC
including
fibroblasts,
myeloid-derived
suppressor
cells,
stellate
tumor-associated
macrophages,
neutrophils,
regulatory
T
cells.
In
present
review,
we
aim
fully
explore
landscape
discuss
current
targeting
provide
thoughts
for
further
research
preclinical
testing.
Язык: Английский
Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer
Cancer Letters,
Год журнала:
2025,
Номер
614, С. 217523 - 217523
Опубликована: Фев. 6, 2025
Язык: Английский
SJB2-043, a USP1 Inhibitor, Suppresses A549 Cell Proliferation, Migration, and EMT via Modulation of PI3K/AKT/mTOR, MAPK, and Wnt Signaling Pathways
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 155 - 155
Опубликована: Фев. 27, 2025
Objective:
Non-small
cell
lung
cancer
(NSCLC)
remains
one
of
the
most
significant
contributors
to
cancer-related
mortality.
This
investigation
explores
influence
and
underlying
mechanisms
USP1
inhibitor
SJB2-043
on
A549
cells,
with
aim
advancing
development
anti-NSCLC
therapeutics.
Methods:
Publicly
available
databases
were
utilized
assess
expression
its
association
progression
NSCLC.
Gene
variations
ascertained
through
RNA
sequencing,
followed
by
Kyoto
Encyclopedia
Genes
Genomes
Ontology
pathway
enrichment
evaluations.
Various
doses
administered
cells
evaluate
impact
multiplication,
motility,
apoptosis,
cycle
using
CCK-8
assays,
colony
formation,
wound
healing,
flow
cytometry,
Western
blotting
(WB).
Results:
was
found
be
overexpressed
in
NSCLC
specimens
linked
adverse
prognosis.
Treatment
markedly
inhibited
proliferation
migration,
diminished
clonogenic
potential,
triggered
apoptosis
a
dose-dependent
manner.
Modifications
observed,
showing
an
elevated
percentage
G2
phase
while
exhibiting
parallel
decline
G1
phase.
WB
examination
demonstrated
protein
levels
N-cadherin,
CyclinB1,
CDK1,
C-myc,
Bcl-2,
p-ERK/ERK,
p-p38/p38,
p-JNK/JNK,
p-AKT/AKT,
p-mTOR/mTOR,
alongside
upregulation
E-cadherin,
ZO-1,
occludin,
p53,
Bax,
p-β-catenin/β-catenin,
GSK3β.
Conclusions:
exerts
suppressive
effect
proliferation,
epithelial–mesenchymal
transition
enhancing
apoptosis.
These
cellular
effects
appear
mediated
inhibition
MAPK,
Wnt/β-catenin,
PI3K/AKT/mTOR
signaling
cascades,
addition
modulation
cycle.
Язык: Английский
SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217726 - 217726
Опубликована: Апрель 1, 2025
Язык: Английский
Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma
Cancer Letters,
Год журнала:
2024,
Номер
601, С. 217162 - 217162
Опубликована: Авг. 9, 2024
Язык: Английский
Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer
Nanomedicine,
Год журнала:
2024,
Номер
19(24), С. 1977 - 1993
Опубликована: Сен. 3, 2024
Aim:
To
evaluate
the
anti-pancreatic
cancer
effect
of
novel
Tubeimoside
I
multifunctional
liposomes
combined
with
gemcitabine.
Язык: Английский