The role of cGAS-STING signaling pathway in colorectal cancer immunotherapy: Mechanism and progress DOI
Yan Luo, Gai Liang, Qu Zhang

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113447 - 113447

Опубликована: Ноя. 7, 2024

Язык: Английский

Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy DOI
Lingzhi Wang, Shengnan Bi, Zhuo Li

и другие.

Biomaterials, Год журнала: 2024, Номер 313, С. 122766 - 122766

Опубликована: Авг. 22, 2024

Язык: Английский

Процитировано

8
A Lyophilizable LNP Vaccine Enables STING-Reinforced Postoperational Adjuvant Immunotherapy DOI Creative Commons
Yi Yang,

Jiaxin Guo,

Jialong Qi

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Immune checkpoint blockade therapy (iCBT) has revolutionized cancer treatment, however, there is a low response rate, especially in treating postsurgical reoccurring tumors. Vaccine based immunotherapy can sensitize iCBT, but its development was largely hindered by inefficient delivery and high requirements of storage. In this study, the vaccine loaded with immunostimulant employed to improve iCBT-based adjuvant therapy. A lyophilized, antigen E7 peptide manganese ion (Mn2+) co-delivered tumor developed on lipid nanoparticles (EM@LNP). The vaccination efficacy examined both prophylactic therapeutic schemes murine subcutaneous models, synergetic effect combined anti-PD-1 further investigated post-operative model. EM@LNP elicited effective CD8+T cell through modulating immunosuppressive microenvironment conferring immune memory, demonstrating potent immunization preventive schemes. What’s more, orchestrated efficiently repressing recurrence. Further mechanism studies using inhibitor for cells invitro investigation STING−/− mice confirmed that cGAS-STING signaling pathway activated Mn2+ indispensable LNP coordination immunotherapy. summary, study shows lyophilized could significantly amplify iCBT efficiency, providing translational strategy

Язык: Английский

Процитировано

0
Role of liposomes in chemoimmunotherapy of Breast cancer DOI

Fatemeh Attarian,

Ghazaleh Hatamian,

Shamim Nosrati

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43

Опубликована: Фев. 19, 2025

In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.

Язык: Английский

Процитировано

0
A syringeable immunotherapeutic hydrogel enhances T cell immunity via in-situ activation of STING pathway for advanced breast cancer postoperative therapy DOI Creative Commons
Baozhen Zhang, Min Li,

Jiahua Ji

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Complete surgical resection of advanced breast cancer is highly challenging and often leaves behind microscopic tumor foci, leading to inevitable relapse. Postoperative formation the immunosuppressive microenvironment (TME) reduces efficacy immunotherapies against residual tumors. Although cytotoxic chemotherapeutics exert capacity intensify immunotherapy via immunogenic cell death (ICD) effects, systemically administered chemo agents cannot access sites, fail elicit antitumor immune responses. Herein, we present a novel syringeable immunotherapeutic hydrogel (SiGel@SN38/aOX40) loaded with DNA-targeting chemotherapeutic 7-ethyl-10-hydroxycamptothecin (SN38) anti-OX40 agonist antibody (aOX40). The sustained in-site release SN38 aOX40 activate stimulator interferon genes (STING) pathway, type I interferons expression, synergistically facilitate dendritic (DC) activation, initiate persistent T mediated responses within bed that eliminate tumors no recurrence in 120 days. Collectively, our designed SiGel@SN38/aOX40 induces robust long-lasting tumoricidal immunity following exhibit immense potential for clinical translation.

Язык: Английский

Процитировано

0
Nano-Delivery of STING Agonists: Unraveling the Potential of Immunotherapy DOI
Meng Zhang,

Yating Ji,

Mingxia Liu

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
cGAS-STING activation by nanodelivery of teniposide achieves colorectal cancer chemo-immunotherapy DOI

Anqi Liao,

Junjun Chen,

Fangzhou Shi

и другие.

European Polymer Journal, Год журнала: 2024, Номер 219, С. 113379 - 113379

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

3
Multifaceted roles of cGAS-STING pathway in the lung cancer: from mechanisms to translation DOI Creative Commons
Mingming Wei,

Qingzhou Li,

Shengrong Li

и другие.

PeerJ, Год журнала: 2024, Номер 12, С. e18559 - e18559

Опубликована: Ноя. 22, 2024

Lung cancer (LC) remains one of the most prevalent and lethal malignancies globally, with a 5-year survival rate for advanced cases persistently below 10%. Despite significant advancements in immunotherapy, substantial proportion patients LC fail to respond effectively these treatments, highlighting an urgent need novel immunotherapeutic targets. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway has gained prominence as potential target improving immunotherapy due its pivotal role enhancing anti-tumor immune responses, augmenting tumor antigen presentation, promoting T cell infiltration. However, emerging evidence also suggests that cGAS-STING may have pro-tumorigenic effects context LC. This review aims provide comprehensive analysis pathway, including biological composition, activation mechanisms, physiological functions, well dual roles current treatment strategies pathway. By addressing aspects, we intend highlight target, while considering challenges future directions clinical application.

Язык: Английский

Процитировано

2
Potential therapeutic strategies for colitis and colon cancer: bidirectional targeting STING pathway DOI Creative Commons

Jiaorong Qu,

Yajie Cai,

Fanghong Li

и другие.

EBioMedicine, Год журнала: 2024, Номер 111, С. 105491 - 105491

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

2
Obesity-Associated Colorectal Cancer DOI Open Access
Lucía G. Gutiérrez, Omar Motiño, Daniel Barriuso

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8836 - 8836

Опубликована: Авг. 14, 2024

Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through secretion of proinflammatory cytokines. addition an increased response, obesity-associated presents accrued molecular factors related characteristics, such as genome instability, sustained cell proliferation, telomere dysfunctions, angiogenesis, and microbial alteration, among others. Despite evidence accumulated over last few years, treatments CRC do not differ from in normal-weight individuals. this review, we summarize current knowledge on cancer, including its epidemiology, factors, treatments. Finally, enumerate possible new therapeutic targets may improve conditions obese patients. key development CRC, resulting reversal should be considered strategy improving antineoplastic therapies.

Язык: Английский

Процитировано

2
The role of cGAS-STING signaling pathway in colorectal cancer immunotherapy: Mechanism and progress DOI
Yan Luo, Gai Liang, Qu Zhang

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113447 - 113447

Опубликована: Ноя. 7, 2024

Язык: Английский

Процитировано

2