Clinical Medicine Insights Oncology,
Год журнала:
2024,
Номер
18
Опубликована: Янв. 1, 2024
Background:
Breast
cancer
(BRCA),
the
hormone
related
malignant
tumor,
is
well-known
for
poor
prognosis.
ZNF208
mainly
acts
as
a
transcription
factor
in
various
tumors,
and
single
nucleotide
polymorphisms
(SNPs)
of
are
to
telomere
length.
Nevertheless,
its
role
breast
tumorigenesis
largely
unknown.
Methods:
We
systematically
investigated
gene
expression,
prognostic
value,
promoter
methylation
BRCA
with
Gene
Expression
Profiling
Interactive
Analysis
(GEPIA)
DNA
Methylation
Visualization
Database
(DNMIVD).
Meanwhile,
we
clarified
association
tumor-infiltrating
immune
cells
(TICs)
from
Tumor
Immune
Estimation
Resource
(TIMER).
Furthermore,
determined
biological
process
functional
enrichment
Cancer
single-cell
state
atlas
(CancerSEA).
Finally,
verified
our
results
analysis
immunohistochemistry
(IHC)
assay.
Results:
discovered
that
was
downregulated
cancer,
low
expression
predicted
worse
prognosis
patients.
The
level
obviously
increased,
associated
TlCs
BRCA.
In
addition,
could
inhibit
metastasis
invasion
processes,
regulate
MAPK
RAS
signaling
pathways
Conclusion:
Our
findings
illustrate
can
function
tumor
suppressor
predict
cancer.
Expert Review of Anticancer Therapy,
Год журнала:
2024,
Номер
24(10), С. 1021 - 1028
Опубликована: Авг. 17, 2024
Not
all
eligible
breast
cancer
(BC)
patients
could
afford
the
expensive
test
of
21-gene
recurrence
score
(RS)
assay.
This
study
aimed
to
identify
clinicopathological
factors
associated
with
high-risk
RS
and
examine
whether
these
correlate
benefit
chemotherapy.
Abstract
With
the
emergence
of
high‐quality
sequencing
technologies,
further
research
on
transcriptomes
has
become
possible.
Circular
RNA
(circRNA),
a
novel
type
endogenous
molecule
with
covalently
closed
circular
structure
through
“back‐splicing,”
is
reported
to
be
widely
present
in
eukaryotic
cells
and
participates
mainly
regulating
gene
protein
expression
various
ways.
It
becoming
hotspot
non‐coding
field.
CircRNA
shows
close
relation
several
varieties
autoimmune
diseases
(AIDs)
both
physiological
pathological
level
could
potentially
used
clinically
terms
diagnosis
treatment.
Here,
we
focus
reviewing
importance
circRNA
AIDs,
aim
establishing
new
biomarkers
providing
insights
into
understanding
role
functions
AIDs.
Specific
signaling
pathways
how
RNAs
are
regulated
AIDs
will
also
illustrated
this
review.
Technology in Cancer Research & Treatment,
Год журнала:
2025,
Номер
24
Опубликована: Март 1, 2025
Breast
cancer
is
one
of
the
leading
causes
cancer-related
deaths
in
women
worldwide.
Circular
RNAs
(circRNAs),
a
novel
class
endogenous
noncoding
RNA
with
covalently
closed
continuous
loop
that
lacks
5′-cap
structure
and
3′-poly
A
tail,
are
more
stable
than
linear
less
susceptible
to
degradation
by
nucleases.
CircRNAs
widespread
multiple
mammalian
genomes
have
been
detected
various
tissues,
cells
body
fluids.
Increasing
evidence
shows
abnormal
expression
circRNAs
involved
development
variety
diseases,
including
breast
cancer.
Numerous
studies
explored
potential
as
biomarkers
malignant
tumors.
In
this
review,
we
aim
provide
comprehensive
overview
latest
advances
promising
early
diagnosis,
prognosis,
molecular
type,
metastasis
drug
resistance
ABSTRACT
Proline‐
and
serine‐rich
coiled‐coil
1
(PSRC1)
has
been
implicated
in
various
cancers,
yet
its
role
breast
cancer
(BRCA)
remains
incompletely
understood.
Here,
we
employed
the
UALCAN
database
to
explore
PSRC1
expression
BRCA
obtained
survival
prognosis
data
from
Kaplan–Meier
Plotter
database.
Additionally,
was
analyzed
81
pairs
of
tissues
their
corresponding
adjacent
noncancerous
through
quantitative
real‐time
PCR,
western
blotting,
immunohistochemistry.
We
observed
overexpressed
tissues,
especially
triple
negative
(TNBC).
Higher
levels
correlated
with
poorer
outcomes
for
patients.
In
tumor
protein
were
significantly
associated
positive
vessel
embolus.
Subsequently,
clinical
relevance
assessed
using
chi‐square
test,
model
a
Log‐rank
as
well
univariate
multivariate
analyses.
Patients
high
had
worse
prognoses.
Elevated
served
an
independent
predictor
prognosis.
Moreover,
investigated
effects
on
cell
phenotypes
MCF‐7
BT549
cells
used
mouse
xenograft
determine
vivo
effect.
Both
vitro
experiments
demonstrated
that
silencing
inhibited
proliferation,
migration,
development.
summary,
our
results
indicate
is
closely
linked
patient
could
be
valuable
prognostic
biomarker
this
disease.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5439 - 5439
Опубликована: Май 16, 2024
Breast
cancer,
when
advancing
to
a
metastatic
stage,
involves
the
liver,
impacting
over
50%
of
cases
and
significantly
diminishing
survival
rates.
Presently,
lack
tailored
therapeutic
protocols
for
breast
cancer
liver
metastasis
(BCLM)
underscores
need
deeper
understanding
molecular
patterns
governing
this
complication.
Therefore,
by
analyzing
differentially
expressed
genes
(DEGs)
between
primary
tumors
BCLM
lesions,
we
aimed
shed
light
on
diversities
process.
This
research
investigated
relapse
employing
comprehensive
approach
that
integrated
data
filtering,
gene
ontology
KEGG
pathway
analysis,
overall
identification
alteration
in
DEGs,
visualization
protein–protein
interaction
network,
Signor
2.0,
positively
correlated
genes,
immune
cell
infiltration
genetic
alternation
copy
number
variant
gene-to-mRNA
interaction,
transcription
factor
docking,
potential
treatment
targets.
study’s
integrative
unveiled
metabolic
reprogramming,
suggesting
altered
PCK1
LPL
expression
as
key
recurrence.
