International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125151 - 125151
Опубликована: Дек. 1, 2024
Язык: Английский
MedComm, Год журнала: 2024, Номер 5(9)
Опубликована: Сен. 1, 2024
Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.
Язык: Английский
Процитировано
12
Advanced Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Abstract Ovarian cancer (OC) remains a formidable gynecological malignancy with limited therapeutic options and substantial side effects associated conventional treatments. Berberine (BBR), natural isoquinoline alkaloid, has shown promising anti‐cancer properties; however, its mechanisms of action in OC are not fully elucidated. In this study, an integrative approach is employed that combines network pharmacology, molecular docking, dynamics stability analysis bulk RNA sequencing (bulk RNA‐seq) to identify OC‐related targets BBR. vivo vitro experiments demonstrate BBR significantly inhibited tumor growth metastasis mouse peritoneal model. Moreover, it further confirmed modulates the microenvironment under high‐lipid conditions by activating Superoxide Dismutase2 (SOD2), reducing lipid metabolism, decreasing Reactive Oxygen Superspecies (ROS) levels.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106924 - 106924
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107742 - 107742
Опубликована: Апрель 1, 2025
Cancer continues to be among the most substantial health challenges globally. Among various natural compounds, berberine, an isoquinoline alkaloid obtained from Coptidis Rhizoma, has garnered considerable attention for its broad-spectrum biological activities, including anti-inflammatory, antioxidant, anti-diabetic, anti-obesity, and anti-microbial activities. Furthermore, berberine exhibits a broad spectrum of anti-cancer efficacy against malignancies, such as ovarian, breast, lung, gastric, hepatic, colorectal, cervical, prostate cancers. Its mechanisms are multifaceted, encompassing inhibition cancer cell proliferation, prevention metastasis, induction apoptosis, facilitation autophagy, modulation tumor microenvironment gut microbiota, enhancement conventional therapeutic strategies. This paper offers exhaustive overview cancer-fighting characteristics Rhizoma while also exploring recent developments in nanotechnology aimed at enhancing bioavailability berberine. side effects safety addressed well. The potential role artificial intelligence optimizing berberine's applications is highlighted. provides precious perspectives on prospective application management cancer.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(21), С. 5079 - 5079
Опубликована: Окт. 27, 2024
Fungal infections present a significant health risk, particularly in immunocompromised individuals. Berberine, natural isoquinoline alkaloid, has demonstrated broad-spectrum antimicrobial activity, though its antifungal potential and underlying mechanisms against both yeast-like filamentous fungi are not fully understood. This study investigates the efficacy of berberine Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, mentagrophytes vitro, as well therapeutic murine model cryptococcal infection. Berberine showed strong with MIC values ranging from 64 to 128 µg/mL. SEM TEM analyses revealed that induced notable disruptions cell wall membrane C. neoformans. No signs necrosis or apoptosis were observed fungal cells treated 2 × berberine, it did increase intracellular ROS levels affect mitochondrial potential. Molecular docking binding affinity assays interaction between enzyme CYP51, dissociation constant (KD) less than 1 10−12 M, suggesting potent inhibition ergosterol biosynthesis. In vivo studies further promoted healing guinea pigs infected T. mentagrophytes, infection model, prolonged survival reduced lung inflammation, showing comparable fluconazole. These findings indicate exerts effects through disruption CYP51 inhibition, highlighting promising option for infections.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 125151 - 125151
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0