Targeting tumor microenvironment with RGD-functionalized nanoparticles for precision cancer therapy

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217536 - 217536

Опубликована: Фев. 1, 2025

Язык: Английский

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Neural-cancer Crosstalk: Reciprocal Molecular Circuits Driving Gastric Tumorigenesis and Emerging Therapeutic Opportunities

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217589 - 217589

Опубликована: Фев. 1, 2025

Язык: Английский

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Osteopontin promotes tumor microenvironment remodeling and therapy resistance

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217618 - 217618

Опубликована: Март 1, 2025

Язык: Английский

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Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 17, 2025

Patients with advanced cancer frequently endure severe pain, which substantially diminishes their quality of life and can adversely impact survival. Analgesia, a critical modality for alleviating such is now under scrutiny its potential role in progression, relationship whose underlying mechanisms remain obscure. Emerging evidence suggests that lactate, once considered metabolic byproduct, actively participates the malignant progression by modulating both immunological pathways within tumor microenvironment. Furthermore, lactate implicated modulation cancer-related exerting effects through direct indirect mechanisms. This review synthesizes current understanding lactate's production, transport, functional roles cells, encompassing regulation metabolism, immunity, progression. Additionally, we dissect complex, bidirectional between assess anesthetics on pain relief, homeostasis, tumorigenesis.

Язык: Английский

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Hypoxia-induced NDRG1 C-terminal Poly-phosphorylation Impairs its Tumor Suppressor Function in Renal Cell Carcinoma

Cancer Letters, Год журнала: 2025, Номер 619, С. 217659 - 217659

Опубликована: Март 24, 2025

Язык: Английский

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