Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders

Antioxidants, Год журнала: 2024, Номер 13(4), С. 484 - 484

Опубликована: Апрель 18, 2024

The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic dysfunction inflammation linked dysbiosis ultimately onset progression central nervous system (CNS) disorders. In accordance hormesis, polyphenols display biphasic dose-response by activating at a low dose Nrf2 pathway resulting upregulation

Язык: Английский

---

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 17, 2025

Obesity is a major modifiable risk factor leading to neuroinflammation and neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting release pro-inflammatory factors such as cytokines adipokines. These inflammatory mediators circulate through bloodstream, propagating inflammation both periphery central nervous system. Gut dysbiosis, which results leaky intestinal barrier, exacerbates plays significant role linking pathogenesis neurodegeneration gut-brain/gut-brain-liver axis. Inflammatory states within brain can lead insulin resistance, mitochondrial dysfunction, autolysosomal increased oxidative stress. disruptions impair normal neuronal function subsequently cognitive decline motor deficits, similar pathologies observed neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, Parkinson's disease. Understanding underlying disease mechanisms crucial for developing therapeutic strategies address defects these metabolic pathways. In this review, we summarize provide insights different strategies, methods alter gut lifestyle changes, dietary supplementation, well pharmacological agents derived from natural sources, that target obesity-induced

Язык: Английский

---

Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 199, С. 114280 - 114280

Опубликована: Апрель 6, 2024

Язык: Английский

---

A review of chitosan-based nanocarriers as drug delivery systems for brain diseases: Critical challenges, outlooks and promises

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134962 - 134962

Опубликована: Авг. 22, 2024

Язык: Английский

---

Mechanism Explanation on Improved Cognitive Ability of D-Gal Inducing Aged Mice Model by Lactiplantibacillus plantarum MWFLp-182 via the Microbiota–Gut–Brain Axis

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(17), С. 9795 - 9806

Опубликована: Апрель 12, 2024

Gut microbiota can influence cognitive ability via the gut–brain axis. Lactiplantibacillus plantarum MWFLp-182 (L. MWFLp-182) was obtained from feces of long-living individuals and could exert marked antioxidant ability. Interestingly, this strain reduced D-galactose-induced impaired in BALB/c mice. To comprehensively elucidate underlying mechanism, we evaluated colonization, antioxidant, anti-inflammatory activities L. MWFLp-182, along with expression potential genes associated influenced gut microbiota. enhanced cytokines, proinflammatory increased tight junction protein colon. Moreover, modify Notably, treatment upregulated postsynaptic density protein-95, nuclear factor erythroid 2-related factor, nerve growth superoxide dismutase, brain-derived neurotrophic factor/neuronal nuclei, while downregulating bcl-2-associated X malondialdehyde hippocampus upregulating short-chain fatty acids against mouse brain deficits. Accordingly, improve a D-galactose-inducing model.

Язык: Английский

---

Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140375 - 140375

Опубликована: Янв. 1, 2025

Язык: Английский

---

The Role of Reactive Oxygen Species in Alzheimer's Disease:from Mechanism to Biomaterials Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(29)

Опубликована: Март 21, 2024

Alzheimer's disease (AD) is a chronic, insidious, and progressive neurodegenerative that remains clinical challenge for society. The fully approved drug lecanemab exhibits the prospect of therapy against pathological processes, while debatable adverse events conflict with concentration required anticipated therapeutic effects. Reactive oxygen species (ROS) are involved in progression AD, as has been demonstrated much research regarding oxidative stress (OS). contradiction between dosage event may be resolved through targeted transport by biomaterials get effects via regulation ROS. Besides, fix delivery issues promoting penetration drugs across blood-brain barrier (BBB), protecting from peripheral degradation, elevating bioavailability. goal to comprehensively understand mechanisms ROS AD potential ROS-related treatment AD. This review focuses on OS its connection novel recent years inspire biomaterial development. Revisiting these associated thorough investigations presents considerable bright future improving effective interventions

Язык: Английский

---

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

ACS Omega, Год журнала: 2024, Номер 9(33), С. 35223 - 35242

Опубликована: Авг. 5, 2024

Neurodegenerative diseases, encompassing conditions such as Alzheimer's disease, Parkinson's multiple sclerosis, amyotrophic lateral prion and Huntington's present a growing health concern human life expectancy increases. Despite this, effective treatments to halt disease progression remain elusive due various factors, including challenges in drug delivery across physiological barriers like the blood-brain barrier patient compliance issues leading treatment discontinuation. In response, innovative approaches leveraging noninvasive techniques with higher are emerging promising alternatives. This Review aims synthesize current options encountered managing neurodegenerative while also exploring modalities. Specifically, strategies intranasal administration nanosized systems gaining prominence for their potential enhance efficacy adherence. Nanosized systems, liposomes, polymeric micelles, nanoparticles, evaluated within context of outstanding studies. The advantages disadvantages these discussed, providing insights into therapeutic limitations. Through this comprehensive examination, contributes ongoing discourse surrounding development diseases.

Язык: Английский

---

Comparing the effects of empagliflozin and liraglutide on lipid metabolism and intestinal microflora in diabetic mice

PeerJ, Год журнала: 2024, Номер 12, С. e17055 - e17055

Опубликована: Март 15, 2024

Recent studies have shown that the imbalance of intestinal flora is related to occurrence and progression diabetic nephropathy (DN) can affect lipid metabolism. Sodium-dependent glucose transporters 2 (SGLT2) inhibitor glucagon-like peptide-1 (GLP-1) receptor agonist are commonly used hypoglycemic drugs excellent renal safety. The purpose this study was compare protective effects empagliflozin liraglutide on kidneys, metabolism, microbiota in mice. We established a mouse model type two diabetes by feeding rats high-fat diet (HFD) followed an intraperitoneal injection STZ. mice were randomly divided into groups: normal control (NC), (DM), treatment (LirT), (EmpT), combined with (Emp&LirT) groups. Blood glucose, lipids, creatinine, uric acid, as well urinary nitrogen albumin levels measured. tissues subjected HE, PAS Masson's staining. These parameters evaluate function histopathological changes Mice feces also collected for 16sRNA sequencing analyze composition flora. All indexes significantly improved after drugs. With respect both decreased serum triglyceride mice, but effect reducing cholesterol better than empagliflozin. However, had reduction low-density lipoproteins (LDL). different At phylum level, reduced ratio Firmicutes Bacteroidota, no seen liraglutide. genus them number Helicobacter increased Lactobacillus. Empagliflozin abundance Muribaculaceae, Muribaculum, Olsenella, Odoribacter, while Ruminococcus. Liraglutide able improve diabetes-related injury. ability reduce LDL compared In addition, their intestine bacterial different.

Язык: Английский

---

Theabrownin from Qingzhuan tea prevents high-fat diet-induced MASLD via regulating intestinal microbiota

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116582 - 116582

Опубликована: Апрель 19, 2024

The aim of this study was to investigate whether the therapeutic effect theabrownin extracted from Qingzhuan tea (QTB) on metabolic dysfunction-associated steatosis liver disease (MASLD) is related regulation intestinal microbiota and its metabolite short-chain fatty acids (SCFAs). Mice were divided into four groups received normal diet (ND), high-fat (HFD) HFD+QTB (180, 360 mg/kg) for 8 weeks. results showed that QTB significantly reduced body weight HFD mice, ameliorated lipid dyslipidemia, increased level SCFAs in mice. 16 S rRNA relative abundance Bacteroides, Blautia Lachnoclostridium their main metabolites acetate propionate after intervention. Colidextribacter, Faecalibaculum Lactobacillus reduced. can also up-regulate expression ATGL, PPARα, FFAR2 FFAR3, inhibit LXRα, SREBP-1c, FAS HMGCR genes. This makes it possible act as a prebiotic prevent MASLD.

Язык: Английский

---