Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(2), С. 1096 - 1113
Опубликована: Янв. 3, 2024
This
study
was
sought
to
investigate
the
chemical
composition
and
antibacterial
antiulcerative
colitis
(UC)
effects
of
essential
oil
from
Pruni
Semen
(PSEO).
A
GC-MS
assay
showed
that
major
compounds
in
PSEO
were
products
amygdalin
hydrolysis,
which
possessed
great
anti-inflammatory
potential.
In
vitro
experiments
demonstrated
treatment
inhibited
activity
four
kinds
intestinal
pathogens
probably
by
disrupting
cell
wall.
Further
vivo
studies
administration
significantly
improved
physiological
indexes,
attenuated
histopathological
characteristics,
proinflammatory
cytokine
production
dextran
sulfate
sodium
(DSS)-induced
UC
mice.
Network
pharmacology
molecular
docking
results
predicted
might
prevent
via
regulating
PI3K/AKT
pathway.
Western
blotting
immunofluorescence
assays
further
conducted
for
verification,
evidenced
intervention
regulated
pathway
expression
its
downstream
proteins
DSS-induced
provide
a
new
dietary
strategy
treatment.
