International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139113 - 139113
Опубликована: Дек. 1, 2024
Язык: Английский
Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122478 - 122478
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139863 - 139863
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
1
Journal of Ethnopharmacology, Год журнала: 2025, Номер 343, С. 119446 - 119446
Опубликована: Фев. 4, 2025
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 25, 2024
The great potential of polysaccharides in immunological regulation has recently been highlighted pharmacological and clinical studies. Polysaccharides can trigger immunostimulatory responses through molecular identification, intra- intercellular communication via direct or indirect interactions with the immune system. Various their derivative compounds interacts at cellular level to boost system, including arabinogalactans, fucoidans, mannans, xylans, galactans, hyaluronans, fructans, pectin etc. These natural are derived from various plants, animals microbes. A unique structural diversity identified polysaccharides, while monosaccharides glucosidic bonds mainly confer diverse biological activities. improve antioxidant capacity, reduce production pro-inflammatory mediators, strengthen intestinal barrier, influence composition microbial populations promote synthesis short-chain fatty acids. also known excessive inflammatory responses. It is crucial develop polysaccharide-based immunomodulators that could be used prevent treat certain diseases. This review highlights features, immunomodulatory properties, underlying mechanisms naturally occurring activities related effects by elucidating a complex relationship between immunity. In addition, future these molecules as components transform pharmaceutical applications will highlighted.
Язык: Английский
Процитировано
5
Food Chemistry, Год журнала: 2024, Номер 466, С. 142146 - 142146
Опубликована: Ноя. 19, 2024
Язык: Английский
Процитировано
4
Опубликована: Янв. 1, 2025
A novel natural polysaccharide (LSP) was isolated and purified from Lactuca sativa L. The structure of LSP characterized using various techniques, including FT-IR, IC, Congo red, XRD, DSC, SEM, AFM, NMR. Furthermore, its in vivo hypoglycemic activity as an adjuvant studied a diabetic mouse model induced by HFD/STZ. findings revealed that possesses molecular weight 1.3 × 10⁶ kDa, with primary structural elements identified →4)-α-D-Glcp-(1→, →4,6)-α-Glcp-(1→, α-Araf-(1→, →6)-β-D-Galp-(1→, →3,4)-β-Xylp-(1→, →4)-β-D-GalpA-(1→. contains Ara, Gal, Glc, Xyl GalA molar ratio 0.44:1:2.07:2.11:0.77. is semi-crystalline polymer lacking triple helix exhibiting stable thermal properties below 200°C. Studies on demonstrated the conjunction metformin significantly improved effects, decreased body weight, boosted antioxidant capacity, enhanced lipid profiles, insulin sensitivity, hepatic glycolysis-related enzyme activities mice compared to alone. This research presents conceptual rationale for exploring function polysaccharides, highlighting their potential adjunctive role control diabetes mellitus.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
In this report, we detail the discovery and characterization of a new oligosaccharide, PCO-1, extracted from culture broth marine fungus Penicillium citrinum SCAU-268. The molecular weight PCO-1 was accurately measured to be 1476 Da, its primary structure identified as α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,6)-α-D-Glcp-(1,6)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp. Our results demonstrate that markedly elevated secretion cytokines IL-6, IL-1β, TNF-α, nitric oxide (NO) in concentration-dependent fashion. Metabolomic studies suggest may act through LACC1 pathway, promoting conversion citrulline ornithine modulating immune responses. conclusion, our study has successfully elucidated fungal-derived oligosaccharide confirmed potent immunomodulatory activity.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(3), С. 675 - 675
Опубликована: Фев. 3, 2025
Artemisia ordosica Krasch. represents a medicinal species traditionally and extensively employed in traditional medicine for treating ailments such as rheumatic arthritis, sore throat, inflammation. This study initially focuses on the extraction, purification, characterization of polysaccharides (AOP). The purified AOP exhibits molecular mass corresponding to 9.00 kDa consists multiple monosaccharide units, with glucose (54.08%) predominant component, followed by arabinose (13.75%), mannose (13.43%), galactose (12.79%), xylose (3.15%), glucuronic acid (0.93%), galacturonic (0.67%), ribose (0.63%), fucose (0.56%), respectively. Furthermore, explore immune-regulatory mechanisms AOP, peripheral blood lymphocytes (PBLs) were cultured exposed inhibitors targeting receptors signaling molecules. results indicated that TLR4 serves potential target through which exerts its immunomodulatory functions. mitigates immune stress PBLs triggered LPS disrupting interaction between TLR downregulating over-activation nuclear factor kappa B (NF-κB) pathway. In summary, shows promise feed additive protect animals from stress.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 24, 2025
Astragalus membranaceus (Fisch.) Bunge and Angelica sinensis (Oliv.) Diels forms a classic herb pair (Qi-Gui her pair) in Chinese medicine, which was commonly used for treating menstrual anemia microvascular ischemic diseases. While polysaccharides are known to be key bioactive components of the Qi-Gui pair, their structural characteristics pharmacological activities remain underexplored. In this research, homogeneous polysaccharide with molecular weight 18.1 kDa isolated, its structure analyzed via high pressure size exclusion chromatography, performance liquid gas chromatography mass spectrometry, nuclear magnetic resonance spectroscopy. The analysis revealed that AAPS-1a composed α-T-Glc p (5.9%), β-1,3-Gal (3.9%), α-1,4-Man (3.6%), α-1,4-Gal (2.1%), α-1,4-Glc (2.8%), α-1,6-Glc (81.7%). Furthermore, NMR consists repeat unit: -(1→4)-α-Gal -(1→4)-α-Man -(1→4)-α-Glc -(1→[6)-α-Glc -(1] n →3)-β-Gal -(1→. vitro studies showed could significantly inhibit proliferation HCT116 cells, induces G1 arrest G2/M arrest, as well apoptosis cells. This study presents inaugural report establishing connection between herbal anti-colon cancer activity, demonstrating holds promise therapeutic agent treatment colon cancer.
Язык: Английский
Процитировано
0