International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138956 - 138956
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
ABSTRACT Functional endoscopic sinus surgery (FESS) is a widely recognized clinical treatment for chronic sinusitis. Nasal packing materials possess tunable biodegradability and strong antibacterial properties to prevent bleeding infection after nasal surgery. In this study, series of hemostatic sponges have been successfully fabricated with quaternized gelatin (QGE) chitosan (CS) as promising materials. The QGE/CS demonstrate high liquid absorption capacity (62.3 g/g), satisfactory compressive strengths in both wet (8.8 kPa) dry (42.0 states, an optimal degradation rate (36.6%) within 3 days. When QGE content greater than 25 wt%, exhibits excellent biocompatibility 99.9% activity against S. aureus E. coli . positively charged porous enhance the concentrate coagulation factors, leading effective performance. rabbit septum trauma model, significantly outperformed commercial PVA sponges, reducing hemostasis time by nearly 180 s decreasing blood loss up 67.3%. 3‐day biodegradation profile properties, offer significant potential controlling post‐surgical bleeding, improving patient postoperative comfort, preventing FESS.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Abstract Wound healing is a dynamic process often accompanied by bacterial infection. Bacterial proliferation and induced excessive inflammation hinder the in infectious wounds, leading to refractory wounds. Addressing challenges of wounds requires development multifunctional dressings capable eliminating infection, relieving inflammation, restoring wound microenvironment. In this study, Ag + ‐ion functionalized Cu 2+ UiO‐67 metal‐organic framework (MOF‐Ag MOF‐Cu) are incorporated into an oxidized dextran gelatin mixture fabricate hydrogel, termed as OGAC. The resulting OGAC exhibited injectable, adhesive, hemostatic, antibacterial, anti‐inflammatory properties, along with good biocompatibility. hydrogel precursor could be injected situ at site cover wound, serving physical barrier protect Moreover, demonstrates efficient antibacterial anti‐biofilm activity, against both Escherichia coli Staphylococcus aureus . Additionally, has superoxide dismutase‐like glutathione peroxidase‐like activity for anti‐oxidation, which conducive reduce wound. reveals high performance infected mouse model. These findings suggest that promising candidate multiple functionalities clinical management.
Язык: Английский
Процитировано
0
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Апрель 11, 2025
Abstract Terahertz (THz) devices, owing to their distinctive optical properties, have achieved myriad applications in diverse domains including wireless communication, medical imaging therapy, hazardous substance detection, and environmental governance. Concurrently, mitigate the impact of electronic waste generated by traditional materials, sustainable materials-based THz functional devices are being explored for further research taking advantages eco-friendliness, cost-effective, enhanced safety, robust biodegradability biocompatibility. This review focuses on origins biological structures materials as well succinctly elucidates latest device fabrication, communication macromolecule detection sensors, environment monitoring biomedical therapeutic devices. We highlight recent protein-based monitoring. Besides, this explores developmental prospects integrating with presenting potential future.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123655 - 123655
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163182 - 163182
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101361 - 101361
Опубликована: Ноя. 22, 2024
Promoting wound nerve regeneration and synchronously initiating angiogenesis are critical factors in the healing process of diabetic wounds. However, existing research on wounds mainly focuses angiogenesis, bacterial infection reactive oxygen species, often failing to coordinate neurogenesis angiogenesis. To symbiosis nerves blood vessels wounds, we successfully designed a multifunctional chitosan (CS)-based sponges by regulating structure CS specifically for healing. This sponge, which facilitates effective exudate transfer modulates microenvironment, was constructed using hydroxybutyl grafted with thioctic acid (TA), named as HCT sponge. When applied humid environment, hydrophobic side chains sponge interact self-assembled domains, forming gel-sponge composite. Experimental results showed that adhesion strength wet porcine skin 70.3 kPa. Additionally, exhibited favorable degradability, cytocompatibility antioxidant properties. As it is shown experiments vitro, can not only promote cell proliferation, migration, vessel formation, but also M2 macrophage polarization. Moreover, rat liver femoral artery injury model validated effectively treat heavy bleeding from efficacy through quickly sealing formation multiple hemostatic dams. In vivo studies indicated significantly accelerated compared recombinant bovine basic fibroblast growth factor gel, achieving better recovery after 15 days. Pathological show novel holds considerable promise treating wound, allowing regenerative at site, provides significant potential further improving clinical applications.
Язык: Английский
Процитировано
2
Foods, Год журнала: 2024, Номер 13(24), С. 4009 - 4009
Опубликована: Дек. 11, 2024
The effect of tilapia skin gelatin properties on the characteristics high internal phase emulsions (HIPEs) and quality 3D printing remains unidentified. In this work, HIPEs were constructed by with various that obtained heat treatment. results indicated undergoes degradation gradually an increase in heating intensity. highest values intrinsic fluorescence intensity, surface hydrophobicity, emulsification when time was 5 h. gel strength hardness hydrogels negatively correlated treatment temperature. extracted at 70 °C demonstrated a suitable material for printing. storage modulus (G′) viscosity exhibited similar tendency as gelatin. microstructure revealed established network around oil droplets, higher G′ corresponded to more compact structure. This study elucidated correlation between structure gelatin, offering essential insights formulation natural which is applications across several domains.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138956 - 138956
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0