Nanosensitizer-assisted sonodynamic therapy for breast cancer

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 7, 2025

Abstract Breast cancer is the most commonly diagnosed worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics. Sonodynamic therapy (SDT) a promising approach for tumor elimination, using sonosensitizers that preferentially accumulate tissues are activated by low-intensity ultrasound produce reactive oxygen species. However, clinical translation of SDT faces challenges, including limited efficiency resistance posed microenvironment. The emergence nanomedicine offers innovative strategies address these obstacles. This review discusses enhancing efficacy sonosensitizers, rational structural modifications, improved tumor-targeted enrichment, microenvironment remodeling, imaging-guided therapy. Additionally, SDT-based multimodal therapies, such as sono-chemotherapy, sono-immunotherapy, sono-photodynamic therapy, their potential applications breast treatment summarized. underlying mechanisms briefly outlined. Finally, this highlights current challenges prospects SDT, providing insights into future may improve outcomes cancer. Graphical abstract

Язык: Английский

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Effects of chitosan on plant growth under stress conditions: similarities with plant growth promoting bacteria

Frontiers in Plant Science, Год журнала: 2024, Номер 15

Опубликована: Ноя. 8, 2024

The agricultural use of synthetic pesticides, fertilizers, and growth regulators may represent a serious public health environmental problem worldwide. All this has prompted the exploration alternative chemical compounds, leading to exploring potential chitosan PGPB in systems as biotechnological solution establish novel production practices that not only result fewer adverse impacts on environment but also improve resilience plants. In work, an analysis impact plant growth-promoting bacteria (PGPB) protection been conducted, emphasizing crucial bioactivities resistance plants both biotic abiotic stressors. These include inducing phytohormone production, mobilization insoluble soil nutrients, biological nitrogen fixation, ethylene level regulation, controlling phytopathogens, etc. Moreover, some relevant aspects chitin are discussed, including their structures, sources, how physical properties related beneficial effects applications mechanisms action. photosynthesis, germination, root development, against diseases have compared, intriguing similarities synergistic observed these aspects. Although currently there limited studies focused combined application chitosan, it would be important consider highlighted those emerge future or through well-designed investigations, because could permit advancing towards greater knowledge obtain better formulations by combining bioproducts, especially for new contexts sustainable agriculture. Thus, seems feasible augur promising near combinations, considering wide range possibilities offered chitinous biomaterials development innovative formulations, well allowing different methods. Likewise, appear expanding due ongoing research test microorganisms derived from environments, whether known recently discovered, making very exciting field research.

Язык: Английский

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A review on the biological activities and the nutraceutical potential of chitooligosaccharides

Carbohydrate Research, Год журнала: 2024, Номер 548, С. 109336 - 109336

Опубликована: Ноя. 28, 2024

Язык: Английский

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 318 - 336

Опубликована: Окт. 18, 2024

Язык: Английский

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