Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 18, 2024
AbstractBackground:
Traditional
antibiotics
are
often
ineffective
against
biofilm-associated
infections,
and
biofilm-induced
macrophage
immune
evasion
directly
halts
the
wound
healing
process.
Disrupting
biofilms
regulating
functions
critical
to
improving
healing.
Results:
In
this
study,
we
synthesized
g-C3N4
with
peroxidase
(POD)
enzyme
activity
via
thermal
polymerization
copper
alginate
microspheres
(CAM)
gas
cutting.
These
were
co-encapsulated
into
GelMA
hydrogels
form
a
functionalized
repair
system
(GelMA/CAM@g-C3N4)
both
anti-biofilm
local
microenvironment
remodeling
capabilities.
vitro,
exhibited
excellent
biocompatibility
promoted
endothelial
cell
migration,
vascular
formation,
CD31
expression.
It
also
polarized
macrophages
toward
M1
phenotype,
restoring
their
pro-inflammatory
functions,
upregulating
inflammatory
cytokines
(IL-1,
IL-6,
TNF-α),
inhibiting
Staphylococcus
aureus
Escherichia
coli.
vivo,
suppressed
S.
growth,
angiogenesis
collagen
deposition,
reshaped
pathological
achieve
regeneration.
Conclusions:
This
offers
new
therapeutic
strategy
for
chronic
infectious
wounds.
