A Carboxymethyl Cellulose Nano Bridges Enhanced F127 Hydrogel with Anti-Inflammatory Activities for Preventing Peritoneal Adhesion and Healing Wounds

Опубликована: Янв. 1, 2025

Postoperative peritoneal adhesion (PPA) is a common and severe postoperative complication which doesn't have satisfactory precautions for surgeons yet. We developed an FC hydrogel by adding F127 to carboxymethyl cellulose (CMC) network. CMC abundant in hydrogen bonding sites, significantly enhance the intermolecular cross-linking as macromolecule bridges hydrogel, resulting longer degradation time, better tissue adhesive ability, mechanical properties. Also, networks bring anti-inflammatory activity hydrogel. The was free-flowing injectable under 12.5 °C gelled situ at body temperature. It demonstrated outstanding hemocompatibility, biocompatibility, biodegradability. Furthermore, its effects of anti-adhesion assessed PPA rat model. Treating with reduced incidence rats from 95.8% 25.0%, scores Hydrogel group were substantially reduced. Pathological analysis further confirmed effects. In addition, immunohistochemical analyses Western-blot tests revealed significant reductions expressions TGF-β1 α-SMA abdominal wall cecum group. Overall, could be safe, reliable, user-friendly barrier, it also showed wound healing promotion anti-inflammation abilities.

Язык: Английский

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Development of a multifunctional eggshell membrane-supported silk conduit for enhanced repair of peripheral nerve injuries

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112152 - 112152

Опубликована: Янв. 1, 2025

Язык: Английский

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Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106633 - 106633

Опубликована: Янв. 1, 2025

Язык: Английский

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Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Язык: Английский

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Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery

Gels, Год журнала: 2025, Номер 11(3), С. 169 - 169

Опубликована: Фев. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Язык: Английский

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An Injectable, Self‐Adaptive Hydrogel with Metallic‐Functionalized Metal Organic Frameworks for Enhanced Wound Healing in Dynamic Infectious and Inflammatory Microenvironment

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Abstract Wound healing is a dynamic process often accompanied by bacterial infection. Bacterial proliferation and induced excessive inflammation hinder the in infectious wounds, leading to refractory wounds. Addressing challenges of wounds requires development multifunctional dressings capable eliminating infection, relieving inflammation, restoring wound microenvironment. In this study, Ag + ‐ion functionalized Cu 2+ UiO‐67 metal‐organic framework (MOF‐Ag MOF‐Cu) are incorporated into an oxidized dextran gelatin mixture fabricate hydrogel, termed as OGAC. The resulting OGAC exhibited injectable, adhesive, hemostatic, antibacterial, anti‐inflammatory properties, along with good biocompatibility. hydrogel precursor could be injected situ at site cover wound, serving physical barrier protect Moreover, demonstrates efficient antibacterial anti‐biofilm activity, against both Escherichia coli Staphylococcus aureus . Additionally, has superoxide dismutase‐like glutathione peroxidase‐like activity for anti‐oxidation, which conducive reduce wound. reveals high performance infected mouse model. These findings suggest that promising candidate multiple functionalities clinical management.

Язык: Английский

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Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Skin soft‐tissue expansion, a key technique for tissue regeneration, promotes repair by applying sustained mechanical tension. However, prolonged tension leads to the accumulation of apoptotic cells and impaired macrophage efferocytosis, thereby disrupting immune homeostasis inhibiting regeneration. In this study, an ultrasound‐driven electric‐conversion hydrogel system (SHG@GBT) is developed, integrating piezoelectric heterojunctions with reorganized network. This modulates efferocytosis through ultrasound‐generated electrical signals, optimizing microenvironment promoting Piezoelectric are created coupling interfaces graphene oxide (GO) barium titanate (BTO) at multiple scales embedded in network formed cross‐linking oxidized hyaluronic acid hydrazide‐modified acid. The compatibility ultrasound response enhanced energy conversion efficiency, GO/BTO heterojunction improving BTO polarization GO charge transfer. Under stimulation, local electric field generated activated calcium ion channels, increasing influx enhancing angiogenesis, collagen synthesis. vivo studies have shown reduced improved blood perfusion. study introduces noninvasive modulation strategy optimize efficacy safety skin soft expansion.

Язык: Английский

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Critical review of the criterion of polysaccharide purity

Carbohydrate Polymers, Год журнала: 2024, Номер 352, С. 123187 - 123187

Опубликована: Дек. 24, 2024

Язык: Английский

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