Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (Dioscorea polystachya and Dioscorea bulbifera) DOI Creative Commons
So-Yoon Park, Van‐Long Truong,

Su–Gyeong Jeon

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 173 - 173

Опубликована: Янв. 8, 2025

Korean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from Dioscorea polystachya bulbifera RAW 264.7 macrophage cells. Among extracts, 95% extract exhibited most potent inhibition reactive oxygen species (ROS) nitric oxide (NO) production, warranting further exploration its mechanisms action. Further analysis revealed that modulated key inflammatory signaling pathways, including MAPK NF-κB, contributing to activity. Additionally, mucilage polysaccharides, a component yams, were extracted characterized for their structural functional These polysaccharides demonstrated immune-enhancing effects by reducing ROS NO production while increasing phagocytic activity Their prebiotic was also assessed through microbial growth assays, which showed an enhanced proliferation beneficial bacteria such as Lactobacillus Bifidobacterium. Furthermore, adhesion assays using Caco-2 intestinal epithelial cells these promoted probiotic inhibiting pathogenic bacteria. findings highlight emphasizing promising applications anti-inflammatory, immune-modulating, agents food nutraceutical development.

Язык: Английский

Anti-Inflammatory and Prebiotic Potential of Ethanol Extracts and Mucilage Polysaccharides from Korean Yams (Dioscorea polystachya and Dioscorea bulbifera) DOI Creative Commons
So-Yoon Park, Van‐Long Truong,

Su–Gyeong Jeon

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 173 - 173

Опубликована: Янв. 8, 2025

Korean yams are abundant in bioactive compounds with significant health-promoting properties. This study evaluated the anti-inflammatory potential of ethanol and water extracts from Dioscorea polystachya bulbifera RAW 264.7 macrophage cells. Among extracts, 95% extract exhibited most potent inhibition reactive oxygen species (ROS) nitric oxide (NO) production, warranting further exploration its mechanisms action. Further analysis revealed that modulated key inflammatory signaling pathways, including MAPK NF-κB, contributing to activity. Additionally, mucilage polysaccharides, a component yams, were extracted characterized for their structural functional These polysaccharides demonstrated immune-enhancing effects by reducing ROS NO production while increasing phagocytic activity Their prebiotic was also assessed through microbial growth assays, which showed an enhanced proliferation beneficial bacteria such as Lactobacillus Bifidobacterium. Furthermore, adhesion assays using Caco-2 intestinal epithelial cells these promoted probiotic inhibiting pathogenic bacteria. findings highlight emphasizing promising applications anti-inflammatory, immune-modulating, agents food nutraceutical development.

Язык: Английский

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