Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications DOI Open Access
Nerea Guembe-Michel, Paul Nguewa, Gustavo González‐Gaitano

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1499 - 1499

Опубликована: Фев. 11, 2025

Poor water solubility remains a significant challenge in the pharmaceutical industry that limits therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made polyethylene glycol, polyvinyl caprolactam, acetate, has been gaining interest recent years as it addresses these limitations by acting versatile carrier. Its ability to form stable amorphous dispersions enhance drug solubility, well its physicochemical properties, support role key excipient advanced delivery systems. Recent investigations have demonstrated adaptability SLP addressing requirements, offering controlled release, improved targeting, superior outcomes. This review examines some formulation methods make use SLP, including hot-melt extrusion, spray drying, electrospinning, drug–polymer layering, capsule tablet formulations, highlighting capacity overcome challenges. Biomedical applications also explored, with focus on improving antitumoral, anti-inflammatory, antimicrobial, antiparasitic drugs.

Язык: Английский

Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications DOI Open Access
Nerea Guembe-Michel, Paul Nguewa, Gustavo González‐Gaitano

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1499 - 1499

Опубликована: Фев. 11, 2025

Poor water solubility remains a significant challenge in the pharmaceutical industry that limits therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made polyethylene glycol, polyvinyl caprolactam, acetate, has been gaining interest recent years as it addresses these limitations by acting versatile carrier. Its ability to form stable amorphous dispersions enhance drug solubility, well its physicochemical properties, support role key excipient advanced delivery systems. Recent investigations have demonstrated adaptability SLP addressing requirements, offering controlled release, improved targeting, superior outcomes. This review examines some formulation methods make use SLP, including hot-melt extrusion, spray drying, electrospinning, drug–polymer layering, capsule tablet formulations, highlighting capacity overcome challenges. Biomedical applications also explored, with focus on improving antitumoral, anti-inflammatory, antimicrobial, antiparasitic drugs.

Язык: Английский

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