Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

AAPS PharmSciTech, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 8, 2025

Язык: Английский

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Natural Regenerative Hydrogels for Wound Healing

Gels, Год журнала: 2024, Номер 10(9), С. 547 - 547

Опубликована: Авг. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Язык: Английский

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Preparation and Drug Release Behavior Study of Intelligent pH-Responsive Sodium Alginate/κ-Carrageenan Polysaccharide-based Hydrogels

Food Bioscience, Год журнала: 2025, Номер unknown, С. 105975 - 105975

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review

Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 564 - 586

Опубликована: Дек. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Язык: Английский

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Characterization and Otoprotective Effects of Polysaccharides from Arthrospira platensis

Molecules, Год журнала: 2025, Номер 30(2), С. 224 - 224

Опубликована: Янв. 8, 2025

Hearing loss is one of the most common sensory disorders in humans, and a large number cases are due to ear cell damage caused by ototoxic drugs including anticancer agents, such as cisplatin. The recent literature reported that hearing promoted an excessive generation reactive oxygen species (ROS) cochlea cells, which causes oxidative stress. Recently, polysaccharides from cyanobacterium Arthrospira platensis showed many biological activities, antioxidant activity, suggesting their potential use combat loss. On these bases, this study describes extraction, purification, characterization water-soluble A. (SPPs) investigation protective role against cisplatin toxicity on House Ear Institute-Organ Corti (HEI-OC1) cells. results SPPs (5–80 µg/mL) induced dose-dependent increase viability, statistically significant at 40 µg/mL 80 µg/mL. Moreover, SPPs, evaluated µg/mL, inhibited cisplatin-induced ROS level HEI-OC1. This evidence highlights natural candidates protect cochlear cells agents. view microalgal realize hydrogels, could also represent healthy carrier for other topically administered otoprotective

Язык: Английский

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Research progress on marine polysaccharide-based Pickering emulsions and their potential applications in the food industry

Food Research International, Год журнала: 2025, Номер unknown, С. 116073 - 116073

Опубликована: Фев. 1, 2025

Язык: Английский

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Microalgae in health care and functional foods: β-glucan applications, innovations in drug delivery and synthetic biology

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 4, 2025

Microalgae are emerging as a key player in healthcare, functional foods, and sustainable biotech due to their capacity produce bioactive compounds like β-glucans, omega-3 fatty acids, antioxidants an eco-friendly manner. This review comprehensively discusses the role of microalgae healthcare focusing particularly on β-glucan therapeutics, drug delivery innovations, synthetic biology applications. In microalgae-derived show immense promise for treating diseases, boosting immunity, tackling oxidative stress. Euglena -derived paramylon, type β-glucan, has shown potential various medical applications, including immunomodulation anticancer therapy. Synthetic bioprocess engineering enhancing microalgae’s therapeutic nutritional value, with applications personalized medicine. To maximize microalgae, further research development needed address scalability, regulatory alignment, consumer acceptance, focus interdisciplinary collaboration practices align innovation environmental conservation.

Язык: Английский

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Deep Analysis of Patella caerulea Calcined Shells for Microwave Applications

Fırat Üniversitesi Mühendislik Bilimleri Dergisi, Год журнала: 2025, Номер 37(1), С. 341 - 350

Опубликована: Март 12, 2025

This study investigates the potential application of Patella caerulea shells collected from Iskenderun Bay as biomaterial in microwave radomes and examines dielectric properties calcined at 600-1200 °C. At central frequency 10 GHz, real permittivity values for P600, P800, P1000 P1200 are 3.2, 2.3, 2.4 2.5, respectively. The corresponding imaginary parts GHz 0.82, 0.44, 0.52 0.56, reflecting temperature-dependent variations. loss factor shells, particularly 2.5 indicates their low-loss applications communication, such laminate radome applications. Moreover, these materials have been integrated to a traditional patch antenna show feasibility system substrate layer. temperatures exceeding 800 °C, slight increase CaO peaks was observed X-ray diffraction spectrum. thermal gravimetric analysis differential shell powder reveal weight occurring two distinct stages minor endothermic 125°C 275°C. highlights that promising due high impedance matching properties. research contributes exploration marine-sourced economic ecological benefits field technology.

Язык: Английский

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From preparation to application: Functional carrageenan-based hydrogels for biomedical and sensing uses

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102668 - 102668

Опубликована: Апрель 1, 2025

Язык: Английский

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Roles and mechanisms of fucoidan against dermatitis: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135268 - 135268

Опубликована: Сен. 2, 2024

Язык: Английский

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