Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(29), С. 10877 - 10900
Опубликована: Июль 11, 2023
There
is
growing
interest
in
reducing
the
number
of
synthetic
products
or
additives
and
replacing
them
with
natural
ones.
The
pharmaceutical,
cosmetic,
food
industries
are
especially
focused
on
bioactive
chemicals
isolated
from
plants
microorganisms.
main
challenge
here
to
develop
efficient
ecological
methods
for
their
isolation.
According
strategies
rules
sustainable
development
green
chemistry,
solvents
environmentally
friendly
technologies
must
be
used.
application
deep
eutectic
as
biodegradable
seems
a
promising
alternative
traditional
methods.
They
classified
being
but,
most
importantly,
very
extraction
media
compared
organic
solvents.
aim
this
review
present
recent
findings
extraction,
well
biological
activities
possible
applications
plant
ingredients,
namely,
phenolics,
flavonoids,
terpenes,
saponins,
some
others.
This
paper
thoroughly
reviews
modern,
ecological,
use
(DESs).
newest
findings,
factors
influencing
efficiency
such
water
content,
hydrogen
bond
donor
acceptor
types,
systems,
also
discussed.
New
solutions
major
problem
separating
DESs
extract
solvent
recycling
presented.
BioFactors,
Год журнала:
2021,
Номер
47(2), С. 232 - 241
Опубликована: Март 1, 2021
Abstract
COVID‐19
leads
to
severe
respiratory
problems,
but
also
long‐COVID
syndrome
associated
primarily
with
cognitive
dysfunction
and
fatigue.
Long‐COVID
symptoms,
especially
brain
fog,
are
similar
those
experienced
by
patients
undertaking
or
following
chemotherapy
for
cancer
(chemofog
chemobrain),
as
well
in
myalgic
encephalomyelitis/chronic
fatigue
(ME/CFS)
mast
cell
activation
(MCAS).
The
pathogenesis
of
fog
these
illnesses
is
presently
unknown
may
involve
neuroinflammation
via
cells
stimulated
pathogenic
stress
stimuli
release
mediators
that
activate
microglia
lead
inflammation
the
hypothalamus.
These
processes
could
be
mitigated
phytosomal
formulation
(in
olive
pomace
oil)
natural
flavonoid
luteolin.
BioFactors,
Год журнала:
2020,
Номер
47(2), С. 190 - 197
Опубликована: Окт. 24, 2020
Abstract
Neuroinflammation
leads
to
neurodegeneration,
cognitive
defects,
and
neurodegenerative
disorders.
Neurotrauma/traumatic
brain
injury
(TBI)
can
cause
activation
of
glial
cells,
neurons,
neuroimmune
cells
in
the
release
neuroinflammatory
mediators.
Neurotrauma
immediate
primary
damage
(direct
damage),
responses,
neuroinflammation,
late
secondary
(indirect)
through
mechanism.
Secondary
chronic
inflammation
onset
progression
diseases.
Currently,
there
are
no
effective
specific
therapeutic
options
treat
these
damages
or
Flavone
luteolin
is
an
important
natural
polyphenol
present
several
plants
that
show
anti‐inflammatory,
antioxidant,
anticancer,
cytoprotective,
macrophage
polarization
effects.
In
this
short
review
article,
we
have
reviewed
neuroprotective
effects
neurotrauma
disorders
pathways
involved
We
collected
data
for
study
from
publications
PubMed
using
keywords
mast
diseases,
TBI.
Recent
reports
suggest
suppresses
systemic
responses
Coronavirus
disease
2019
(COVID‐19).
Studies
shown
exhibits
various
mechanisms,
including
suppressing
immune
cell
activation,
such
as
inflammatory
mediators
released
cells.
addition,
suppress
response,
microglia
astrocytes,
oxidative
stress,
severity
diseases
Alzheimer's
disease,
Parkinson's
multiple
sclerosis,
TBI
pathogenesis.
conclusion,
improve
decline
enhance
neuroprotection
TBI,
stroke.
The Science of The Total Environment,
Год журнала:
2021,
Номер
801, С. 149719 - 149719
Опубликована: Авг. 19, 2021
Fruits,
vegetables,
spices,
and
herbs
are
a
potential
source
of
phenolic
acids
polyphenols.
These
compounds
known
as
natural
by-products
or
secondary
metabolites
plants,
which
present
in
the
daily
diet
provide
important
benefits
to
human
body
such
antioxidant,
anti-inflammatory,
anticancer,
anti-allergic,
antihypertensive
antiviral
properties,
among
others.
Plentiful
evidence
has
been
provided
on
great
polyphenols
against
different
viruses
that
cause
widespread
health
problems.
As
result,
this
review
focuses
properties
some
their
action
mechanism
various
types
coronaviruses,
influenza,
herpes
simplex,
dengue
fever,
rotavirus,
Also,
it
is
highlight
relationship
between
antioxidant
activities
can
contribute
protection
cells
tissues
body.
The
wide
variety
mechanisms
agents,
polyphenols,
viral
infections
could
be
applied
treatment
prevention
strategy;
but
at
same
time,
used
produce
drugs.
A
recent
example
an
polyphenol
application
deals
with
use
hesperidin
extracted
from
Citrus
sinensis.
relies
its
binding
key
entry
spike
protein
SARS-CoV-2.
Finally,
extraction,
purification
recovery
activity,
essential
for
virus
replication
infection
without
side-effects,
have
critically
reviewed.
Phytochemistry Reviews,
Год журнала:
2021,
Номер
21(1), С. 291 - 312
Опубликована: Май 22, 2021
Flavonoids
are
a
class
of
phenolic
natural
products,
well-identified
in
traditional
and
modern
medicines
the
treatment
several
diseases
including
viral
infection.
showed
potential
inhibitory
activity
against
coronaviruses
current
pandemic
outbreak
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
designated
as
COVID-19.
Here,
we
have
collected
all
data
related
to
mechanisms
flavonoids
SARS-CoV-2
infection
their
significant
immunomodulatory
activities.
The
were
mapped
compared
elect
major
with
promising
role
pandemic.
Further,
linked
global
existence
medicinal
plants
protection
Computational
analysis
predicted
that
can
exhibit
binding
essential
targets
required
virus
entry
and/
or
replication.
also
excellent
anti-inflammatory
activities
inhibition
various
inflammatory
cytokines.
ability
reduce
exacerbation
COVID-19
case
obesity
via
promoting
lipids
metabolism.
Moreover,
high
safety
profile,
suitable
bioavailability,
no
adverse
effects.
For
instance,
rich
globally
distributed
offer
great
from
described
this
study
strongly
highlighted
particularly
quercetin
luteolin
multi-target
SARS-CoV-2,
which
promote
use
expected
future
outbreaks.
Therefore,
regimen
flavonoid-rich
be
recommended
supplement
sufficient
amount
for
Toxicology Reports,
Год журнала:
2022,
Номер
9, С. 445 - 469
Опубликована: Янв. 1, 2022
Flavonoids
-a
class
of
low
molecular
weight
secondary
metabolites-
are
ubiquitous
and
cornucopia
throughout
the
plant
kingdom.
Structurally,
main
structure
consists
C6-C3-C6
rings
with
different
substitution
patterns
so
that
many
sub-classes
obtained,
for
example:
flavonols,
flavonolignans,
flavonoid
glycosides,
flavans,
anthocyanidins,
aurones,
flavones,
neoflavonoids,
chalcones,
isoflavones,
flavones
flavanones.
evaluated
to
have
drug
like
nature
since
they
possess
therapeutic
activities,
can
act
as
cardioprotective,
antiviral,
antidiabetic,
anti-inflammatory,
antibacterial,
anticancer,
also
work
against
Alzheimer's
disease
others.
However,
information
on
relationship
between
their
biological
activity
is
scarce.
Therefore,
present
review
tries
summarize
all
activities
flavonoids,
mechanisms
action
relationship.
Natural Product Communications,
Год журнала:
2020,
Номер
15(12)
Опубликована: Дек. 1, 2020
Quercetin,
a
naturally
occurring
dietary
flavonoid,
is
well
known
to
ameliorate
chronic
diseases
and
aging
processes
in
humans,
its
antiviral
properties
have
been
investigated
numerous
studies.
In
silico
vitro
studies
demonstrated
that
quercetin
can
interfere
with
various
stages
of
the
coronavirus
entry
replication
cycle
such
as
PLpro,
3CLpro,
NTPase/helicase.
Due
pleiotropic
activities
lack
systemic
toxicity,
derivatives
may
represent
target
compounds
be
tested
future
clinical
trials
enrich
drug
arsenal
against
infections.
There
evidence
combination
with,
for
example,
vitamins
C
D,
exert
synergistic
action
provide
either
an
alternative
or
additional
therapeutic/preventive
option
due
overlapping
immunomodulatory
properties.
This
review
summarizes
significance
proposes
possible
strategy
effective
utilization
natural
polyphenols
our
daily
diet
prevention
viral
infection.
