Concilium,
Год журнала:
2023,
Номер
23(15), С. 604 - 623
Опубликована: Авг. 5, 2023
Hexavalent
chromium
(Cr
VI)
is
a
toxic
and
carcinogenic
agent.
The
aim
of
this
study
was
to
evaluate
the
effects
probiotic
supplementation
on
prostate,
seminal
vesicle,
testis
testosterone
hormone
level
in
rats,
as
preclinical
model,
intoxicated
with
increasing
doses
Cr
VI,
form
potassium
dichromate.
experimental
period
lasted
90
days
used
80
young
male
rats
randomly
allocated
into
eight
groups
(n=10):
two
four
dichromate
incorporated
diet.
After
period,
animals
were
weighed,
euthanized
samples
blood,
vesicle
collected
histological
evaluations
hormonal
measurements
performed.
supplemented
diet
reduced
(p<0.05)
CrVI
levels.
results
also
revealed
that
incorporation
caused
dose-dependent
manner.
Journal of Environmental Science and Health Part C,
Год журнала:
2024,
Номер
unknown, С. 1 - 28
Опубликована: Янв. 19, 2024
The
escalation
of
technological
advancements,
coupled
with
the
increased
use
hazardous
chemicals,
has
emerged
as
a
significant
concern
for
human
health.
Exposure
to
environmental
pollutants
like
heavy
metals
and
pesticides
(insecticides,
herbicides
fungicides)
is
known
significantly
contribute
various
health
problems,
particularly
affecting
reproductive
Disturbances
in
potential
toxicity
males
are
worrisome.
Existing
literature
suggests
that
exposure
these
alters
male
parameters.
Thus,
it
imperative
thoroughly
analyze,
comprehend,
evaluate
their
impact
on
toxicity.
Oxidative
stress
disruptions
redox
equilibrium
major
factors
through
which
induce
changes
sperm
parameters
affect
system.
Insecticides,
fungicides,
act
endocrine
disruptors,
interfering
secretion
function
hormones
such
testosterone
luteinizing
hormone
(LH),
consequently
impacting
spermatogenesis.
Additionally,
reported
bio-accumulate
organs,
acting
disruptors
triggering
oxidative
stress.
co-operative
association
can
lead
severe
damage.
In
this
comprehensive
review,
we
have
conducted
an
in-depth
analysis
system,
shedding
light
underlying
mechanisms
action.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(24), С. 17241 - 17241
Опубликована: Дек. 8, 2023
Hexavalent
chromium
(Cr(VI))
is
a
hazardous
substance
that
poses
significant
risks
to
environmental
ecosystems
and
animal
organisms.
However,
the
specific
consequences
of
Cr(VI)
exposure
in
terms
liver
damage
remain
incompletely
understood.
This
study
aims
elucidate
mechanism
by
which
disrupts
mitochondrial
dynamics,
leading
hepatic
injury
ducks.
Forty-eight
healthy
8-day-old
ducks
were
divided
into
four
groups
subjected
diets
containing
varying
doses
(0,
9.28,
46.4,
232
mg/kg)
for
49
days.
Our
results
demonstrated
resulted
disarranged
lobular
vacuolation,
along
with
increasing
serum
levels
ALT,
AST,
AKP
dose-dependent
manner,
indicated
damage.
Furthermore,
induced
oxidative
stress
reducing
activities
T-SOD,
SOD,
GSH-Px,
GSH,
CAT,
while
contents
MDA
H2O2.
Moreover,
downregulated
CS
MDH,
resulting
energy
disturbance,
as
evidenced
reduced
AMPK/p-AMPK
ratio
PGC-1α
protein
expression.
Additionally,
disrupted
dynamics
through
decreased
expression
OPA1,
Mfn1,
Mfn2
increased
Drp-1,
Fis1,
MFF
proteins.
disruption
ultimately
triggered
mitochondria-mediated
apoptosis,
elevated
caspase-3,
Cyt
C,
Bax,
Bcl-2
Bcl-2/Bax
ratio,
at
both
mRNA
levels.
In
summary,
this
highlights
induces
stress,
inhibits
AMPK-PGC-1α
pathway,
triggers
cell
apoptosis
Environmental Toxicology,
Год журнала:
2024,
Номер
39(5), С. 2655 - 2666
Опубликована: Янв. 15, 2024
Abstract
Thiacloprid
(THI)
is
a
neonicotinoid
insecticide,
and
its
wide‐ranging
use
has
contributed
to
severe
environmental
health
problems.
Dendrobium
officinale
polysaccharide
(DOP)
possesses
multiple
biological
activities
such
as
antioxidant
antiapoptosis
effect.
Although
present
research
shown
that
THI
causes
kidney
injury,
the
exact
molecular
mechanism
treatment
of
THI‐induced
injury
remain
unclear.
The
study
aimed
investigate
if
DOP
could
alleviate
identify
potential
in
quails.
In
this
study,
Japanese
quails
received
(200
mg/kg)
daily
with
or
without
(4
exposure
for
42
days.
Our
results
showed
improved
hematological
changes,
biochemical
indexes,
nephric
histopathological
changes
induced
by
THI.
Meanwhile,
caused
oxidative
stress,
apoptosis,
autophagy.
Furthermore,
cotreatment
significantly
activated
nuclear
factor
erythroid
2‐related
2/heme
oxygenase‐1
(Nrf2/HO‐1)
pathway,
restored
enzyme
activity,
reduced
apoptosis
autophagy
quail
kidneys.
summary,
our
demonstrated
mitigated
THI‐mediated
was
associated
via
activation
Nrf2/HO‐1
signaling
pathway
Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 7, 2024
Abstract
Male
infertility
has
become
a
global
concern,
accounting
for
20–70%
of
infertility.
Dysfunctional
spermatogenesis
is
the
most
common
cause
male
infertility;
thus,
treating
abnormal
may
improve
and
attracted
attention
medical
community.
Mitochondria
are
essential
organelles
that
maintain
cell
homeostasis
normal
physiological
functions
in
various
ways,
such
as
mitochondrial
oxidative
phosphorylation
(OXPHOS).
Mitochondrial
OXPHOS
transmits
electrons
through
respiratory
chain,
synthesizes
adenosine
triphosphate
(ATP),
produces
reactive
oxygen
species
(ROS).
These
mechanisms
vital
spermatogenesis,
especially
to
function
testicular
Sertoli
cells
germ
cells.
The
disruption
caused
by
external
factors
can
result
inadequate
cellular
energy
supply,
stress,
apoptosis,
or
ferroptosis,
all
inhibiting
damaging
reproductive
system,
leading
This
article
summarizes
latest
pathological
mechanism
disorder
cells,
which
disrupts
results
In
addition,
we
also
briefly
outline
current
treatment
spermatogenic
malfunction
disorders.
However,
relevant
treatments
have
not
been
fully
elucidated.
Therefore,
targeting
disorders
research
direction
worthy
attention.
We
believe
this
review
will
provide
new
more
accurate
ideas
Nanomaterials,
Год журнала:
2024,
Номер
14(8), С. 689 - 689
Опубликована: Апрель 17, 2024
Reproductive
disorders
and
declining
fertility
rates
are
significant
public
health
concerns
affecting
birth
future
populations.
Male
infertility,
often
due
to
spermatogenesis
defects,
may
be
linked
environmental
pollutants
like
nickel
nanoparticles
(Ni
NPs).
Ni
NPs
extensively
utilized
across
different
industries.
Nevertheless,
their
potential
adverse
effects
cannot
overlooked.
Previous
studies
have
the
reproductive
toxicity
induced
by
with
disturbances
in
mitochondrial
function.
Mitochondrial
division/fusion
dynamics
crucial
proper
function,
yet
little
is
known
about
how
perturb
these
whether
such
perturbation
contributes
impairment
of
male
system.
Herein,
we
demonstrated
that
exposure
mouse-derived
spermatogonia
cell
line
(GC-1
cells)
triggered
DRP1-mediated
division
enhanced
mitochondria,
consequently
promoting
mitochondria-dependent
apoptosis.
Notably,
both
inhibitor
(Mdivi-1)
lentiviral-transfected
cells
low
expression
Dnm1l-DK
could
mitigate
toxic
NPs,
pointing
role
NP-induced
toxicity.
Collectively,
our
work
understanding
mechanisms
which
can
impact
function
identifies
as
a
target
for
intervention.
