Polymers,
Год журнала:
2024,
Номер
16(18), С. 2580 - 2580
Опубликована: Сен. 12, 2024
Nanocomposites
prepared
with
a
terpolymer
of
poly(L–lactide)
(PLLA)–poly(ε–caprolactone)
(PCL)–poly(ethylene
glycol)
(PEG)
and
partially
oxidized
carbon
nanotubes
(CNTspo)
were
synthesized
characterized
to
evaluate
their
ability
act
as
an
effective
nanocarrier
the
anticancer
drug
methotrexate.
The
homopolymers
PLLA
PCL
through
ring-opening
polymerization
(ROP)
gel
permeation
chromatography
(GPC).
PLLA–PCL–PEG
terpolymers
four-step
chemical
route
using
oxalyl
chloride
linker
agent
analyzed
1H–NMR,
13C–NMR,
FTIR
spectroscopies.
Additionally,
nanocomposites
FTIR,
X-ray
photoelectron
spectroscopy
(XPS),
well
differential
scanning
calorimetry
(DSC)
technique.
XPS
analysis
revealed
that
chains
are
grafted
onto
CNTspo.
Moreover,
evaluations
DSC
strongly
suggest
PCL-rich
domains
preferentially
oriented
toward
release
tests
exhibited
“burst
effect”
profile,
which
was
more
evident
in
than
nanocomposites.
Five
models
used
assess
methotrexate’s
vitro
release.
For
nanocomposites,
best
fit
experimental
data
obtained
first-order
model,
whereas
results
from
Korsmeyer–Peppas
model
indicated
Fickian
diffusion
drives
Next Nanotechnology,
Год журнала:
2023,
Номер
2, С. 100013 - 100013
Опубликована: Июнь 1, 2023
Polymers
show
a
vast
possibility
of
chemical
modification
novel
properties
and
nanomedicine
generation
in
biomedical
fields.
Polymeric
nanoparticle
(PNPs)
is
commonly
used
as
drug
carrier,
they
have
good
biodegradability,
biocompatibility,
high
drug-loading
capacity.
PNPs
are
the
broadly
nanocarrier
including
polymeric
micelles,
liposomes,
dendrimers,
sponges,
colloidal
carriers.
These
NPs
also
low
toxicity,
increased
therapeutic
effectiveness,
improved
penetration,
controlled
release
enhanced
physical
stability.
widely
delivery
system
subsequently
able
to
load
natural
synthetic
agents
including,
protein,
peptides,
growth
factors,
DNAs,
mRNA,
drugs.
can
be
applied
via
several
routes
administration
nasal,
oral,
intravenous,
topical
ocular.
potentially
target
specific
cells/tissues,
promising
way
increase
local
concentration,
decrease
toxicity
side
effects,
prevent
nonspecific
interaction.
The
present
review
focuses
on
biodegradable
polymers,
classifications,
types,
method
preparation
PNPs,
applications
targeted
their
limitations.
This
presents
for
respiratory,
cancers,
liver
cirrhosis,
ocular,
diabetic
wounds,
Alzheimer's
disease.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3187 - 3215
Опубликована: Апрель 1, 2024
Abstract:
Green
synthesis
of
silver
(Ag)
and
gold
(Au)
nanoparticles
(NPs)
has
acquired
huge
popularity
owing
to
their
potential
applications
in
various
fields.
A
large
number
research
articles
exist
the
literature
describing
green
Ag
Au
NPs
for
biomedical
applications.
However,
these
findings
are
scattered,
making
it
time-consuming
researchers
locate
promising
advancements
unexplored
Unlike
other
review
articles,
this
systematic
study
not
only
highlights
recent
but
also
explores
The
article
discusses
approaches
highlighting
emerging
developments
novel
strategies.
Then,
reviews
important
synthesized
by
critically
evaluating
expected
advantages.
To
expose
future
direction
field,
describes
NPs.
Finally,
discuss
challenges
limitations
This
will
serve
as
a
valuable
reference
researchers,
working
on
Keywords:
nanoparticles,
environmental-friendly,
applications,
potentials
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 12, 2024
Endothelial
cells
(ECs)
are
pivotal
in
maintaining
vascular
health,
regulating
hemodynamics,
and
modulating
inflammatory
responses.
Nanocarriers
hold
transformative
potential
for
precise
drug
delivery
within
the
system,
particularly
targeting
ECs
therapeutic
purposes.
However,
complex
interactions
between
nanocarriers
present
significant
challenges
development
clinical
translation
of
nanotherapeutics.
This
review
assesses
recent
advancements
key
strategies
employing
to
ECs.
It
suggested
that
through
physicochemical
design
surface
modifications,
can
enhance
specificity
improve
internalization
efficiency
Additionally,
we
elaborated
on
applications
specifically
designed
treatment
cardiovascular
diseases,
cancer
metastasis,
disorders.
Despite
these
advancements,
safety
concerns,
complexity
vivo
processes,
challenge
achieving
subcellular
remain
obstacles
effective
with
nanocarriers.
A
comprehensive
understanding
endothelial
cell
biology
its
interaction
is
crucial
realizing
full
targeted
systems.
Archiv der Pharmazie,
Год журнала:
2025,
Номер
358(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Developing
efficient
antiviral
protectives
is
a
new
approach
against
respiratory
emerging
viruses.
This
study
aims
to
synthesize
silver
nanoparticles
(Ag
NPs)
via
green
technique
using
crocin
provide
virucidal
effect
and
enhance
the
protection
of
polyacrylonitrile
(PAN)
nanofibrous
face
masks
or
respirators
The
influence
formulation
process
variables
on
particle
size
(PS)
Ag
NPs
was
studied
d
‐optimal
response
surface
design.
selected
were
loaded
into
PAN
nanofibers
(NFs).
MTT
colorimetric
assay
performed
determine
safety
prepared
NFs
Vero
cells.
Further,
an
immunofluorescent
composite's
ability
inhibit
ACE2‐SARS‐CoV‐2
spike
protein
interaction
prevent
viral
infection.
possessed
small
PS
23.21
±
0.86
nm,
PDI
0.23
0.019,
ZP
–21.8
1.82
mV.
optimum
NF
composite
fabricated
with
concentration
8%
w/v
0.25%
w/w
NPs,
feeding
rate
0.7
mL/h
applied
voltage
23.5
kV.
resultant
displayed
acceptable
morphology
mean
diameter
378.88
91.12
nm.
In
vitro
cytotoxicity
studies
cells
revealed
biocompatibility
NPs.
Moreover,
Ag‐PAN
proven
biologically
safe.
showed
that
demonstrated
least
IC50
value
10.99
µg/mL,
indicating
their
potent
inhibiting
SARS‐CoV‐2
are
promising
safe
has
potential
be
used
in
masks.
Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
The
efficacy
of
endodontic
treatments,
essential
for
managing
infections
and
injuries
in
dental
pulp,
heavily
relies
on
completely
eradicating
microorganisms
from
the
root
canal
system.
Traditional
methods
often
fail
to
achieve
thorough
disinfection,
prompting
exploration
polymeric
nanoparticles
their
potential
enhance
cleanliness.
Objectives:
This
systematic
review
aims
evaluate
use
effectiveness
with
a
specific
focus
antimicrobial
properties.
Methods:
Studies
eligible
inclusion
involved
inoculated
canals,
dentine,
or
medicaments
containing
relevant
microbial
species.
interventions
examined
included
application
that
contain
agents,
sometimes
enhanced
by
ultrasound
photodynamic
therapy,
compared
against
control
groups
without
treatment.
primary
outcome
was
reduction
bacterial
load.
Systematic
searches
were
conducted
databases
such
as
PubMed,
Web
Science,
Scopus,
Google
Scholar
completed
January
31,
2024.
risk
bias
assessed
using
modified
Cochrane
tool,
results
synthesized
descriptively
due
heterogeneity
methodologies
reporting
across
studies.
Results:
Nine
studies
met
criteria,
primarily
focusing
strains
like
Enterococcus
faecalis
Staphylococcus
aureus
.
Results
indicated
exhibited
significant
activity,
especially
those
made
chitosan
poly
(lactic‐co‐glycolic
acid)
(PLGA).
suggests
revolutionize
disinfection
processes.
However,
clinical
translation
faces
challenges
ensuring
nanoparticle
stability,
biocompatibility,
cost‐effective
manufacturing
Discussion:
evidence
limited
variability
study
designs
strains,
absence
trials,
inconsistent
precluded
meta‐analysis.
Despite
promising
vitro
results,
several
barriers
hinder
implementation
nanoparticle‐based
therapies.
Long‐term
safety
data
are
sparse,
adverse
effects
inflammatory
responses
resistance
remains
concern.
Additionally,
achieving
optimal
delivery
within
intricate
anatomy
system
requires
further
innovation.
Addressing
these
is
critical
transitioning
experimental
practical
applications.
Human & Experimental Toxicology,
Год журнала:
2025,
Номер
44
Опубликована: Фев. 20, 2025
Introduction
Tamoxifen
(TMX)
shows
promise
in
treating
breast
cancer,
but
it
faces
challenges
such
as
poor
solubility,
instability,
and
incomplete
release
when
targeting
tumors.
Additionally,
TMX
therapy’s
toxicity
is
a
critical
issue
cancer
treatment.
This
study
aimed
to
assess
the
impact
of
hyaluronic
acid
(HA)-coated
TMX-loaded
solid
lipid
nanoparticles
(HA-TMX-SLNs)
on
MCF7
cells.
Methods
Solid
(SLNs)
were
prepared
using
hot
homogenization.
The
HA-TMX-SLNs
TMX-SLNs
characterized
evaluated
through
transmission
electron
microscopy
(TEM).
Cytotoxicity
was
assessed
MTT
assay,
Western
blot
analysis
utilized
identify
key
factors
cell
cycle
apoptosis.
Results
demonstrated
approximately
55%
loading
efficiency
after
100
h.
exhibited
lower
cytotoxicity
cells
compared
other
treatments.
Significant
decreases
expression
levels
cyclin-dependent
kinase
(CDK)
4,
Cyclin
D1,
CDK2,
Bcl2
observed
treatment
with
HA-TMX-SLNs,
along
an
increase
cleaved/procaspase-7.
Discussion
vitro
showed
that
HA-coated
SLNs
consistently
released
drug
into
media
under
controlled
conditions.
Furthermore,
cytotoxic
effects,
increasing
apoptosis
inhibiting
proliferation.
These
findings
suggest
effectively
deliver
