Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 18 - 18
Опубликована: Дек. 26, 2024
Cannabinoids
include
both
endogenous
endocannabinoids
and
exogenous
phytocannabinoids,
such
as
cannabidiol
(CBD),
have
potential
therapeutic
agents
in
cancer
treatment
due
to
their
selective
anticancer
activities.
CBD
exhibits
antioxidant
pro-oxidant
effects
depending
on
its
concentration
cell
types.
These
properties
allow
influence
oxidative
stress
responses
potentially
enhance
the
efficacy
of
antitumor
therapies.
In
this
study,
we
treated
U87MG
glioma
cells
with
low
dose
(1
μM)
evaluated
molecular
effects.
Our
findings
indicate
that
reduced
viability
by
20%
(p
<
0.05)
through
alteration
mitochondrial
membrane
potential.
The
redox
status
caused
an
attempt
rescue
functionality
nuclear
localization
GABP
transcription
factor
involved
mitochondria
biogenesis.
Moreover,
increase
autophagic
flux,
supported
Beclin-1
ratio
LC3-II/LC3-I.
Due
alteration,
pro-apoptotic
proteins
were
induced
without
activating
apoptotic
effectors
Caspase-3
or
Caspase-7.
study
NRF2
ubiquitin-binding
protein
p62
expression
revealed
levels
CBD-treated
cells.
conclusion,
low-dose
makes
more
vulnerable
cytotoxic
effects,
reducing
dynamics
while
increasing
flux
systems.
This
explains
mechanisms
which
respond
treatment.
highlight
CBD,
suggesting
modulating
autophagy
pathways
could
represent
a
promising
strategy
for
glioblastoma
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(5)
Опубликована: Фев. 27, 2025
ABSTRACT
Ferroptosis
plays
a
crucial
role
in
the
pathogenesis
of
osteoarthritis
(OA),
and
inhibition
chondrocyte
ferroptosis
effectively
alleviates
OA
progression.
Krüppel‐like
factor
9
(KLF9)
is
demonstrated
to
be
upregulated
OA,
but
its
molecular
mechanism
remains
unclear.
The
study
aimed
investigate
KLF9
Primary
chondrocytes
were
treated
with
IL‐1β
establish
an
cell
model,
showed
that
was
highly
expressed
IL‐1β‐incubated
chondrocytes.
Knockdown
alleviated
IL‐1β‐induced
degeneration.
In
addition,
decreased
methylation
proportion
gene
promoter.
DNA
methyltransferase
1
(DNMT1)
directly
bound
promoter,
overexpression
DNMT1
inhibited
expression
by
promoting
promoter
Subsequently,
shRNA
pcDNA‐CYP1B1
individually
or
altogether
transfected
into
Cytochrome
P450
1B1
(CYP1B1)
chondrocytes,
abrogated
inhibitory
effect
on
ferroptosis.
Moreover,
Ferrostatin‐1
(Fer‐1,
inhibitor
ferroptosis)
reversed
promotion
Finally,
vivo
experiments
significantly
suppressed
cartilage
tissue
damage,
ferroptosis,
IHC
scores
CYP1B1
rats.
conclusion,
our
results
suggested
KLF9,
epigenetic
silenced
DNMT1,
promoted
extracellular
signal‐regulated
kinase
(ERK)‐mediated
through
transcriptionally
regulating
CYP1B1.
Thus,
expected
new
target
for
treatment
OA.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 13, 2025
Autophagy
is
responsible
for
maintaining
cellular
balance
and
ensuring
survival.
plays
a
crucial
role
in
the
development
of
diseases,
particularly
human
cancers,
with
actions
that
can
either
promote
survival
or
induce
cell
death.
However,
brain
tumors
contribute
to
high
levels
both
mortality
morbidity
globally,
resistance
treatments
being
acquired
due
genetic
mutations
dysregulation
molecular
mechanisms,
among
other
factors.
Hence,
having
knowledge
processes
advancement
enlightening,
current
review
specifically
examines
autophagy.
The
discussion
would
focus
on
pathways
control
autophagy
tumors,
its
dual
as
tumor
suppressor
supporter
different
types
like
glioblastoma,
glioma,
ependymoma,
demonstrating
potential
treatment.
mechanisms
influence
metastasis
drug
there
complex
interplay
between
responses
stress
hypoxia
starvation.
inhibit
growth
by
promoting
apoptosis.
focusing
could
offer
fresh
perspectives
creating
successful
treatments.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 11, 2024
Abstract
Glioma
is
the
most
common
malignant
tumor
in
central
nervous
system,
with
significant
health
burdens
to
patients.
Due
intrinsic
characteristics
of
glioma
and
lack
breakthroughs
treatment
modalities,
prognosis
for
patients
remains
poor.
This
results
a
heavy
psychological
financial
load
worldwide.
In
recent
years,
cannabidiol
(CBD)
has
garnered
widespread
attention
research
due
its
anti-tumoral,
anti-inflammatory,
neuroprotective
properties.
review
comprehensively
summarizes
preclinical
clinical
on
use
CBD
therapy,
as
well
current
status
nanomedicine
formulations
CBD,
discusses
potential
challenges
therapy
future.
