STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

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Methyltransferase-like 3 mediates m6A modification of heme oxygenase 1 mRNA to induce ferroptosis of renal tubular epithelial cells in acute kidney injury

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Acute kidney injury (AKI) involves a series of syndromes characterized by rapid increase in creatinine levels. Ferroptosis, as an iron-dependent mode programmed cell death, reportedly participates the pathogenesis AKI. Methyltransferase-like 3 (METTL3)-mediated m6A modification has been recently associated with various diseases; however, mechanism METTL3 crosstalk molecules involved ferroptosis is not clearly understood. Here, we investigated between METTL3-mediated and was elevated patients AKI, FA-AKI mice, TBHP-stimulated TCMK-1 cells. Inhibition expression vivo vitro alleviated damage renal tubular MeRIP sequencing showed that heme oxygenase 1 (Hmox1/HO-1) target. RIP-qPCR indicated anti-insulin-like growth factor 2 mRNA binding protein 3(IGF2BP3) could be used reader to bind methylated site Hmox1 maintain its stability. knockdown reduced accumulation iron ions ferroptosis. mediates maintains stability IGF2BP3-dependent manner, which causes overload epithelial cells, leading

Язык: Английский

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Antioxidative Function of Zinc and Its Protection Against the Onset and Progression of Kidney Disease Due to Cadmium

Biomolecules, Год журнала: 2025, Номер 15(2), С. 183 - 183

Опубликована: Янв. 27, 2025

Chronic kidney disease (CKD) is now the world’s top seventh cause of death from a non-communicable disease, and its incidence projected to increase further as major risk factors, including obesity, diabetes, hypertension, non-alcoholic fatty liver (NAFLD), continue rise. Current evidence has linked increased prevalence CKD, NAFLD chronic exposure metal pollutant cadmium (Cd). Exposure Cd widespread because diet main route for most people. Notably, however, health dietary underappreciated, existing tolerable guidelines do not afford protection. New health-protective are needed. From one’s diet, absorbed by intestinal epithelium where it passes through accumulates within tubular epithelial cells. Here, bound metallothionine (MT), gradually released, induces damage, tubulointerstitial inflammation fibrosis, nephron destruction. The present review provides an update on our knowledge levels that found be associated with NAFLD, mortality cardiovascular disease. It discusses co-existence hypertension CKD in people environmentally exposed Cd. highlights nuclear mitochondrial targeting zinc deficiency universal cytotoxic mechanisms Special emphasis placed novel antioxidative function involving de novo heme biosynthesis induced expression oxygenase-1 (HO-1). Other exogenous biomolecules promising anti-Cd toxicity highlighted.

Язык: Английский

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The Overlooked Impact of Cadmium on the Progression of Chronic Hepatitis and the Onset of Renal Failure in Advanced Cirrhosis

Journal of Trace Elements in Medicine and Biology, Год журнала: 2024, Номер 86, С. 127542 - 127542

Опубликована: Окт. 6, 2024

Язык: Английский

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Tubular Release of N-acetylglucosaminidase Into Glomerular Filtrate is Minimally Related to Cadmium-Induced Nephron Destruction

Опубликована: Авг. 16, 2024

Exposure to even low levels of the environmental pollutant cadmium (Cd), increases risk kidney damage. The body burden Cd at which damage occurs is not, however, reliably defined. Here, multiple-regression and mediation analyses were applied data from 737 non-diabetic Thai nationals, 32.2% had hypertension 9.1% an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73 m2 (low eGFR). excretion rates (ECd) N-acetyl-β-D-glucosaminidase (ENAG), a marker tubular injury, normalized creatinine clearance (Ccr) as ECd/Ccr ENAG/Ccr. Doubling increased risks having eGFR [POR = 2.71 (95% CI:1.97, 3.74), p < 0.001] severe injury 4.80 CI: 1.35, 17.1), 0.015]. ENAG/Ccr was strongly associated with in both men (β 0.447, <0.001) women 0.394, <0.001), while showing moderate inverse association only −0.178, 0.002). A found low- 0.287, 0.001), high-Cd groups 0.145, 0.004), but inversely group −0.223, <0.001). These findings together insignificant mediated effect suggested that Cd-induced causes release NAG plays little or no role nephron destruction reduces GFR.

Язык: Английский

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Urinary N-acetylglucosaminidase in People Environmentally Exposed to Cadmium Is Minimally Related to Cadmium-Induced Nephron Destruction

Toxics, Год журнала: 2024, Номер 12(11), С. 775 - 775

Опубликована: Окт. 25, 2024

Exposure to even low levels of the environmental pollutant cadmium (Cd) increases risk kidney damage and malfunction. The body burden Cd at which these outcomes occur is not, however, reliably defined. Here, multiple-regression mediation analyses were applied data from 737 non-diabetic Thai nationals, 9.1% had an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73 m

Язык: Английский

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Ginkgetin enhances breast cancer radiotherapy sensitization by suppressing NRF2-HO-1 axis activity

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 495, С. 117199 - 117199

Опубликована: Дек. 8, 2024

Язык: Английский

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