Preliminary investigation on the mechanisms of multi-organ toxicity induced by prolonged inhalation exposure to silica nanoparticles DOI Creative Commons

Jia-Qi Ban,

Li-Hong Ao,

Haiying Gu

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Abstract The increasing use of silica nanoparticles (SiNPs) has raised concerns about their biotoxicity. Since respiratory exposure is the primary route human to SiNPs, this study systematically investigated distribution and damaging effects in lungs, heart, liver, kidneys following tracheal drip injection. results demonstrated that SiNPs distribute across these organs induce mitochondrial damage, endoplasmic reticulum stress, activate cell death pathways, including apoptosis, pyroptosis, autophagy. most significant damage occurred middle-dose group (6 mg/kg). as target organ, exhibited pronounced fibrotic changes, while lesions were also observed varying degrees. These findings suggest injury mechanisms may collectively contribute chronic inflammation promote fibrosis. This provides critical insights into multi-organ toxicity offering a foundation for safety assessment.

Язык: Английский

Preliminary investigation on the mechanisms of multi-organ toxicity induced by prolonged inhalation exposure to silica nanoparticles DOI Creative Commons

Jia-Qi Ban,

Li-Hong Ao,

Haiying Gu

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Abstract The increasing use of silica nanoparticles (SiNPs) has raised concerns about their biotoxicity. Since respiratory exposure is the primary route human to SiNPs, this study systematically investigated distribution and damaging effects in lungs, heart, liver, kidneys following tracheal drip injection. results demonstrated that SiNPs distribute across these organs induce mitochondrial damage, endoplasmic reticulum stress, activate cell death pathways, including apoptosis, pyroptosis, autophagy. most significant damage occurred middle-dose group (6 mg/kg). as target organ, exhibited pronounced fibrotic changes, while lesions were also observed varying degrees. These findings suggest injury mechanisms may collectively contribute chronic inflammation promote fibrosis. This provides critical insights into multi-organ toxicity offering a foundation for safety assessment.

Язык: Английский

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