Magnesium isoglycyrrhizinate regulates oxidative stress and apoptosis via PI3K/AKT1 pathway to improve myocardial remodeling in mice DOI Creative Commons
Kai Qian,

Xingyu Zhou,

Dan Fu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 6, 2023

Abstract The role of magnesium isoglycyrrhizinate (MgIG) in myocardial remodeling is being investigated. We evaluated the result MgIG on isoproterenol (ISO) -enticed mice by activating PI3K/AKT1 pathway. heart function was tested echocardiography, and it found that could improve left ventricular function. Pathological staining analysis showed decrease degree injury caused ISO. serum data detected ELISA reduce content CK-MB, MDA LDH, increase activity GSH-Px. Western blotting protein expressions Collagen Ⅰ, BNP, Bax, Cleaved caspase-3, p-PI3K p-AKT1 were decreased, while Bcl-2, COX2 SOD1 increased. Meanwhile activation PI3K activator (740Y-P) reverses cardioprotective effect MgIG. These findings suggest induced ISO be improved MgIG, its mechanism may associated with inhibite pathway to regulate apoptosis oxidative stress.

Язык: Английский

Glyphosate-Based Herbicide Stress During Pregnancy Impairs Intestinal Development in Newborn Piglets by Modifying DNA Methylation DOI
Guangdong Bai,

Hua Yuan,

Mingming Cao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Glyphosate-based herbicide (GBH), a feed contaminant, has been proven to impair the growth and development of humans animals. Previous research revealed that maternal toxin exposure during pregnancy could cause permanent fetal changes by epigenetic modulation. However, there was insufficient evidence involvement DNA methylation in GBH exposure-induced intestinal health offspring. Here, we established pregnant sow models investigate effects on newborn piglets. The results showed gestational compromises function piglets as well decreases mRNA expression Dnmt1 Dnmt3b jejunum. Further RRBS analysis genomic hypomethylation jejunum, differentially methylated regions were enriched pathways food digestion related GO terms. Additionally, integrative methylome transcriptome identified 23 genes showing inverse correlations indicated underlying injury mechanisms upon GBH. These findings provide new insights fundamental knowledge into possible offspring induced pregnancy, which drives manufacturers develop low-toxicity ensure safety human health.

Язык: Английский

Процитировано

1
Oxidative stress induced by combined glyphosate and TBBPA exposure promotes gill autophagy and inflammation via the PI3K/AKT/mTOR pathway DOI

Mingyue Li,

Shuang Lou,

Kai Chen

и другие.

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110190 - 110190

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Quercetin alleviates DEHP exposure-induced pyroptosis and cytokine expression changes in grass carp L8824 cell line by inhibiting ROS/MAPK/NF-κB pathway DOI

Hao Cai,

Ké Li, Yilin Yin

и другие.

Fish & Shellfish Immunology, Год журнала: 2023, Номер 143, С. 109223 - 109223

Опубликована: Ноя. 14, 2023

Язык: Английский

Процитировано

13
TAN (tannic acid) inhibits BPA-induced pyroptosis of L8824 (grass carp hepatocytes) by regulating PTEN/PI3K/AKT pathway DOI
Xuejiao Yang,

Yuanxin Zhou,

Tingting Yu

и другие.

Fish & Shellfish Immunology, Год журнала: 2024, Номер 146, С. 109384 - 109384

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

5
Associations between urinary glyphosate and arthritis: an US NHANES analysis DOI Creative Commons

Xiaoyao He,

Liangyu Mi,

Miaomiao Zhao

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 13, 2025

Objective As the relationship between urine glyphosate and arthritis in adults general is still unclear, study set out to investigate it. Methods A total of 1,689 people volunteered National Health Nutrition Examination Surveys (US NHANES). Utilizing a multivariate logistic regression model explore association concentrations (both continuous with categorical) risks developing arthritis, as well various types arthritis. Non-linear correlations have been investigated using restricted cubic spline smooth curve fitting. We also conducted additional subgroup analyses categorical defining features. Results Patients had levels 0.4 ng/mL, while non-arthritic individuals 0.3 ng/mL ( p < 0.05). After adjusting for confounding variables, models demonstrated significant positive elevated urinary risk [1.2 (1.0, 1.4)]. This was observed osteoarthritis (OA) subgroup, an odds ratio 1.3 (95% CI: 1.1, 1.6), but not found rheumatoid (RA) or other subgroups. Smooth fitting RCS further elucidate that exhibit dose-dependent both OA, adhering linear trend (with -value nonlinearity exceeding Subsequent studies showed certain groups people, remained significant. Conclusion Increased exposure may be associated particularly osteoarthritis.

Язык: Английский

Процитировано

0
Lycopene abolishes typical polyhalogenated carbazoles (PHCZs)-induced hepatic injury in yellow catfish (Pelteobagrus fulvidraco): Involvement of ROS/PI3K-AKT/NF-κB signaling DOI Creative Commons
Siwen Li, Jiaqi Xie, Dongfang Zhang

и другие.

Fish & Shellfish Immunology, Год журнала: 2023, Номер 139, С. 108897 - 108897

Опубликована: Июнь 8, 2023

Язык: Английский

Процитировано

6
Water extracts of Pueraria thomsonii Radix ameliorates alcoholic liver disease via PI3K/AKT and NOX4/ROS pathways DOI Creative Commons
Kai Yang, Xiaofei Zhang, Ding Liu

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 110, С. 105830 - 105830

Опубликована: Окт. 11, 2023

Pueraria thomsonii Radix. as an important edible and medicinal plant in China, its effects mechanisms on alcoholic liver disease (ALD) remain unclear. Herein, we investigated the of water extracts (WEPT) ALD rat model induced by Chinese Baijiu. The results revealed that, a total 23 compounds were obtained from WEPT UPLC-Q-TOF-MS. Compared with group, group showed significant decrease index serum levels alanine transaminase (ALT), aspartate aminotransferase (AST) Cytochrome P450 2E1 (CYP2E1) livers, increase ethanol dehydrogenase (ADH) acetaldehyde (ALDH) significantly reduced expression HSP90, p-AKT, p-IKK NOX4 tissues. Our study demonstrates that Radix may be beneficial food for disease, inhibited PI3K/AKT NOX4/ROS signaling pathways.

Язык: Английский

Процитировано

6
Hydrolysable tannin improves growth performance and liver health of largemouth bass (Micropterus salmoides) fed high soybean meal diets DOI

Manqi Yang,

Dahai Jiang,

Weibin Lai

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 276, С. 133773 - 133773

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

2
MiR-21 regulates proliferation and apoptosis of mesangial cells via PTEN/PI3K/AKT pathway in lupus nephritis DOI Open Access
Zhifeng Gu, Qian He, Juan Ji

и другие.

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Янв. 30, 2024

Objective: Systemic lupus erythematosus（SLE）is an autoimmune disease involving multiple organs and systems throughout the body. The pathogenesis is complex has not been fully elucidated. Excessive proliferation of human renal mesangial cells（HRMC）and endothelial cells leads to deposition massive immune complexes formation crescents, which main cause nephritis (LN) one complications SLE. Recent studies have demonstrated that miR-21 plays important role in progression SLE, but mechanism remains unclear. purpose this study was determine expression tissues MRL/lpr mice effect on apoptosis HRMC its mechanism. Methods: Real-time fluorescent quantitative PCR (qRT-PCR) used detect kidney C57BL/6 mice. Flow cytometry cells. Western blot BAX, BCL-2 PTEN/ PI3K/AKT signaling pathway. Results: qRT-PCR results showed significantly upregulated affected by BAX participated cell through Conclusion: MiR-21 regulates LN via PI3K/ AKT signaling. These reveal molecular basis influence provide a new approach for therapy nephritis.

Язык: Английский

Процитировано

0
Magnesium isoglycyrrhizinate regulates oxidative stress and apoptosis via PI3K/AKT1 pathway to improve myocardial remodeling in mice DOI Creative Commons
Kai Qian,

Xingyu Zhou,

Dan Fu

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Дек. 6, 2023

Abstract The role of magnesium isoglycyrrhizinate (MgIG) in myocardial remodeling is being investigated. We evaluated the result MgIG on isoproterenol (ISO) -enticed mice by activating PI3K/AKT1 pathway. heart function was tested echocardiography, and it found that could improve left ventricular function. Pathological staining analysis showed decrease degree injury caused ISO. serum data detected ELISA reduce content CK-MB, MDA LDH, increase activity GSH-Px. Western blotting protein expressions Collagen Ⅰ, BNP, Bax, Cleaved caspase-3, p-PI3K p-AKT1 were decreased, while Bcl-2, COX2 SOD1 increased. Meanwhile activation PI3K activator (740Y-P) reverses cardioprotective effect MgIG. These findings suggest induced ISO be improved MgIG, its mechanism may associated with inhibite pathway to regulate apoptosis oxidative stress.

Язык: Английский

Процитировано

0