Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia
Cancers,
Год журнала:
2025,
Номер
17(6), С. 978 - 978
Опубликована: Март 14, 2025
Background:
Exposure
to
pesticides
has
been
associated
with
an
increased
risk
of
developing
childhood
leukemia.
However,
the
impact
on
leukemia
survival
not
examined.
We
investigated
associations
between
residential
pesticide
use
during
key
developmental
periods
and
5-year
in
children
treated
for
acute
lymphoblastic
(ALL).
Methods:
Residential
insecticides,
herbicides,
rodenticides,
flea
control
products
from
preconception
up
12
months
prior
diagnosis
sociodemographic
characteristics
were
collected
via
parental
interview
among
837
diagnosed
ALL
1995
2008
California,
USA.
Data
clinical
features
abstracted
medical
records.
Vital
status
was
obtained
through
linkage
National
Death
Index
(NDI)
2020.
Cox
proportional
hazards
regression
models
used
estimate
hazard
ratios
(HRs),
adjusting
factors
group.
Results:
A
total
108
(~13%)
died
within
5
years
diagnosis.
any
pre-
and/or
postnatally
slightly
higher
deceased
compared
alive
(95.4%
vs.
91.5%;
p
=
0.23),
while
rodenticides
significantly
who
(25.0%)
those
survived
(15.5%;
0.02).
In
fully
adjusted
models,
exposure
mortality
(HR
1.70;
95%
confidence
interval
(CI)
1.08–2.64;
0.02),
especially
when
child
exposed
pregnancy
1.90;
CI
1.15–3.16;
0.01)
possibly
before
1.60;
0.98–2.61;
0.06).
Increased
death
also
observed
other
types
pregnancy,
but
statistically
significant.
Conclusions:
This
study
is
first
report
reduced
previously
particularly
underscoring
need
further
evaluate
mechanisms
by
which
environmental
exposures
stages
may
later
cancer
outcomes.
Язык: Английский
One Health approach and tiered strategy to assess anticoagulant rodenticides exposure in red foxes (Vulpes vulpes) from Central Italy
Environmental Pollution,
Год журнала:
2025,
Номер
unknown, С. 126403 - 126403
Опубликована: Май 1, 2025
Anticoagulant
rodenticides
(ARs)
are
widely
used
in
urban
and
agricultural
areas
to
control
rodent
populations,
leading
potential
exposure
of
non-target
species
like
red
foxes
(Vulpes
vulpes).
However,
data
on
AR
Italy
remain
limited.
This
study
analyzed
92
fox
liver
samples
for
residues
ten
ARs,
categorizing
concentrations
into
five
groups
assess
toxicological
risks.
The
were
also
compared
with
the
CORINE
Land
Cover
dataset
correlated
infectious
parasitic
diseases,
including
respiratory
intestinal
infections.
Residues
at
least
one
found
46
(50%),
25%
containing
AR,
20%
two,
5%
three.
Second-generation
anticoagulant
(SGARs)
more
prevalent
than
first-generation
anticoagulants
(FGARs),
detected
47.9%
samples.
Positive
primarily
from
but
settings.
observed
suggest
biological
risks,
a
significant
correlation
between
ARs
confirms
Italian
highlights
need
integrated
risk
mitigation
strategies
protect
humans,
animals,
environmental
health.
Язык: Английский
Synthesis of metal nanoparticles and their role in degradation of pesticides/herbicides: a review
Deleted Journal,
Год журнала:
2025,
Номер
7(6)
Опубликована: Май 28, 2025
Язык: Английский
Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats†
Pest Management Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 30, 2025
Abstract
BACKGROUND
Anticoagulant
rodenticides
(ARs)
are
used
globally
to
manage
pest
rodent
populations.
However,
resistance
ARs
in
target
populations
challenges
control
efforts
and
can
increase
risks
nontarget
species.
Resistance
is
frequently
associated
with
nonsynonymous
single
nucleotide
polymorphisms
(nsSNPs)
the
Vkorc1
gene,
this
study
carried
out
first
survey
of
introduced
rats
on
Australian
mainland.
RESULTS
We
identified
three
species
rat
using
cytochrome
b
gene
across
Brisbane,
Melbourne,
Perth
Sydney:
Rattus
rattus
(Linnaeus
1758)
(Lineage
I);
norvegicus
(Berkenhout
1769);
tanezumi
(Temminck
1844)
II).
Three
nsSNPs
were
detected
gene:
Tyr25Phe
,
Trp59Arg
Phe55Ile
.
The
mutation
which
ARs,
was
58
108
R.
(53.7%)
one
31
(3.2%).
It
has
been
suggested
that
(detected
two
)
susceptibility
haemorrhage,
whereas
(identified
only
not
reported
previously.
No
CONCLUSION
This
update
status
mainland
since
1970s
employ
genetic
screening.
widespread
occurrence
urbanized
areas
Australia
suggests
potential
common
practical
conferred
by
needs
further
investigation
as
does
role
hybridization
transfer
from
nuclear
genome.
©
2025
Author(s).
Pest
Management
Science
published
John
Wiley
&
Sons
Ltd
behalf
Society
Chemical
Industry.
Язык: Английский
First evidence of the suitability of hair for assessing wildlife exposure to anticoagulant rodenticides (ARs)
Environmental Research,
Год журнала:
2024,
Номер
264, С. 120302 - 120302
Опубликована: Ноя. 5, 2024
Язык: Английский
Assessment of anticoagulant potential of Halocnemum strobilaceum (Pall.) against black rat (Rattus rattus Lin.) from Algeria
Journal of King Saud University - Science,
Год журнала:
2024,
Номер
36(10), С. 103449 - 103449
Опубликована: Сен. 13, 2024
Язык: Английский
Exploring anticoagulant rodenticide exposure and effects in eagle owl (Bubo bubo) nestlings from a Mediterranean semiarid region
Environmental Research,
Год журнала:
2024,
Номер
264, С. 120382 - 120382
Опубликована: Ноя. 16, 2024
Anticoagulant
rodenticides
(ARs)
are
widely
used
for
pest
control,
resulting
in
their
pervasive
presence
the
environment
and
posing
significant
toxicological
risks
to
a
range
of
predatory
scavenging
species.
Our
study
mainly
aimed
evaluate
AR
exposure
effects
nestlings
eagle
owl
(Bubo
bubo)
from
Region
Murcia
(southeastern
Spain).
We
analysed
ARs
blood
samples
(n
=
106)
using
high-performance
liquid
chromatography-triple
quadrupole
(HPLC-TQ),
assessed
influence
potential
anthropogenic
(presence
livestock
farms,
landfills
human
population
density)
environmental
(land
uses
proximity
watercourses)
variables,
measured
prothrombin
time
(PT)
plasma
biochemical
parameters
as
biomarkers
effects.
results
showed
residues
91.5%
nestlings,
with
70.8%
exhibiting
multiple
(up
six
compounds
single
individual).
Second-generation
(SGARs)
were
most
prevalent
compounds.
The
analysis
indicated
that
sampled
individuals
good
physiological
condition.
Although
PT
was
positively
correlated
total
concentration
(ΣARs),
relationship
not
(Rho
0.04;
p
0.49).
Regarding
factors,
higher
ΣARs
associated
urbanised
site
landfills,
likely
due
increased
availability
rodent
prey.
prevalence
two
SGARs
(brodifacoum
difenacoum)
linked
closer
riverbeds,
suggesting
contamination
pathway
inland
aquatic
ecosystems,
where
these
may
concentrate
water
scarcity.
This
underscores
widespread
owls
highlights
importance
effective
monitoring
management
pollutants
protect
conservation-concern
wildlife
Mediterranean
semiarid
regions.
Язык: Английский