World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 6, 2025
The
goal
of
this
review
is
to
highlight
the
role
second-hand
smoke
(SHS)
or
environmental
tobacco
(ETS)
and
e-cigarette
(EC)
vapors
on
brain
integrity
function
during
development
adulthood,
including
how
it
relates
increasing
risk
for
age-related
neurodegenerative
disorders.
A
systematic
literature
effect
SHS
ETS
revealed
a
total
284
372
publications
312
publications,
respectively.
After
taking
into
account
duplicate
focused
policy,
surveys
other
organs
than
brain,
there
are
limited
studies
effects
SHS,
EC
structure
function.
In
review,
we
examine
major
constituents
in
their
health,
mechanisms
by
which
alters
function,
behavioral
cognitive
performance.
We
hope
that
will
encourage
investigators
explore
further
short-as
well
long-term
vapor
exposure
developing
adult
better
understand
its
neurodevelopmental
disorders
diseases
ultimately
develop
therapeutic
modalities
reduce
even
prevent
short-
detrimental
health.
Язык: Английский
Climate change, pollution, and mental health: concerns on rising temperatures and polycyclic aromatic hydrocarbon risks
Discover Environment,
Год журнала:
2025,
Номер
3(1)
Опубликована: Апрель 9, 2025
Abstract
The
rising
global
temperatures
due
to
climate
change
have
a
profound
impact
on
health.
Heat
is
associated
with
many
physical
and
mental
health
conditions.
of
heat
could
be
exacerbated
in
polluted
areas
the
combined
pollutants
stress.
Polycyclic
aromatic
hydrocarbons
(PAHs)
are
among
environmental
public
significance.
Exposure
PAHs
has
adverse
effects
these
worse
oil-impacted
communities
increased
PAH
exposure
degradation.
increases
volatilisation
PAHs,
mobility
availability
formation
toxic
derivatives,
possible
wildfire
incidents
which
introduce
more
into
environment.
This
human
through
various
pathways,
addition
stress,
thereby
worsening
challenges.
anticipated
decrease
levels
reduced
emissions
offset
by
temperatures,
promote
mobilisation
existing
PAHs.
Therefore,
this
review
highlighted
risks
amid
especially
communities.
mechanisms
increase
were
also
highlighted.
Possible
pollution
prevention,
mitigation,
intervention
approaches
suggested.
Rapid
oil
spill
response,
remediation,
ecosystem
restoration,
biomonitoring,
environmental,
agro
products
monitoring
help
mitigate
exposure.
Additionally,
introduction
green
education,
assessment
for
every
project,
investment
sustainable
technologies
companies.
Overall,
creates
awareness
neglected
draws
attention
researchers,
funders,
policymakers,
society
as
we
navigate
challenges
change.
Graphical
Язык: Английский
Long-term effects of PM2.5 constituents on childhood attention deficit hyperactivity disorder: evidence from a large population-based study in the Pearl River Delta Region, China
Environmental Research,
Год журнала:
2025,
Номер
unknown, С. 121641 - 121641
Опубликована: Апрель 1, 2025
Язык: Английский
Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling
Environment International,
Год журнала:
2025,
Номер
199, С. 109484 - 109484
Опубликована: Апрель 17, 2025
Traffic-related
ultrafine
particles
(UFPs)
are
an
emerging
health
concern
affecting
the
brain
and
increasing
risk
of
Alzheimer's
disease
(AD).
PI3K/AKT
signaling
is
known
to
contribute
neuronal
survival
be
altered
in
AD.
The
nasal
olfactory
mucosa
(OM)
a
sensory
tissue
exposed
directly
ambient
air,
starting
point
for
neural
circuits
towards
brain.
Evidence
air
pollution-induced
transcriptional
regulation
via
microRNAs
(miRNA)
DNA
methylation
(DNAmet)
accumulating
pollutant-mediated
disturbances
have
been
reported.
By
utilizing
highly
translational
human-based
vitro
model
OM,
we
aimed
investigate
possible
gene
regulatory
mechanisms
induced
by
UFPs,
compare
responses
between
cognitively
healthy
individuals
with
miRNA
expression
was
analyzed
using
next-generation
sequencing
(NGS)
chip-based
analysis
performed
detect
differentially
methylated
loci
(DML).
These
data
were
combined
previously
published
transcriptomics
(mRNA)
construct
mRNA-miRNA-DNAmet-integrative
network.
Protein
level
changes
studied
immunoassays.
We
observed
UFP-induced
reductions
viability
increases
oxidative
stress
damage
without
eminent
cell
death.
Integrative
network
revealed
multiple
connections
miRNAs
expressed
genes
pathway,
effects
most
prominent
AD
cells.
Similarly,
cells
DML
identified
transcription
factor
apoptosis
genes,
downstream
signaling.
Conclusively,
traffic-related
UFPs
influence
modulate
OM
survival,
existing
pathology
resulting
heightened
vulnerability
UFP
effects.
Язык: Английский
Characteristics, sources, and concentration prediction of endocrine disruptors in a large reservoir driven by hydrological rhythms: A case study of the Danjiangkou Reservoir
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
484, С. 136779 - 136779
Опубликована: Дек. 4, 2024
Язык: Английский
Circadian control of polycyclic aromatic hydrocarbon-induced dysregulation of endothelial tight junctions and mitochondrial bioenergetics
The Science of The Total Environment,
Год журнала:
2024,
Номер
952, С. 175886 - 175886
Опубликована: Авг. 30, 2024
The
study
evaluates
the
impact
of
environmental
toxicants,
such
as
polycyclic
aromatic
hydrocarbons
(PAHs),
on
circadian
regulations
and
functions
brain
endothelial
cells,
which
form
main
structural
element
blood-brain
barrier
(BBB).
PAH
are
lipophilic
highly
toxic
pollutants
that
accumulate
in
human
animal
tissues.
Environmental
factors
related
to
climate
change,
an
increase
frequency
intensity
wildfires
or
enhanced
strength
hurricanes
tropical
cyclones,
may
lead
redistribution
these
toxicants
exposure.
These
natural
disasters
also
associated
with
disruption
rhythms
affected
populations,
linking
increased
exposure
alterations
rhythm
pathways.
Several
vital
physiological
processes
coordinated
by
rhythms,
clock
can
contribute
development
several
diseases.
(BBB)
is
crucial
for
protecting
from
blood-borne
harmful
substances,
its
integrity
influenced
rhythms.
Exposure
cells
a
environmentally-relevant
mixture
resulted
dose-dependent
expression
critical
modulators,
Clock,
Bmal1,
Cry1/2,
Per1/2.
Moreover,
silencing
Clock
gene
potentiated
PAHs
tight
junction
genes
proteins
(namely,
claudin-5,
occludin,
JAM-2,
ZO-2),
well
mitochondrial
bioenergetics.
Findings
this
better
understanding
pathological
influence
PAH-induced
health
effects,
especially
those
disruption.
Язык: Английский