Acute Ventricular Dysfunction After Doxorubicin-Based Induction Therapy for Pediatric Acute Lymphoblastic Leukemia DOI Open Access
Rajkumar Kundavaram, Amber Kumar,

Sushma Konnepati

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Дек. 14, 2024

Background Doxorubicin is an important drug used in the treatment of children with acute leukemia, and cardiotoxicity most serious complication due to its use. The cardiac dysfunction doxorubicin can be acute, early, or late. Echocardiography a non-invasive tool employed detect clinical subclinical plan strategies accordingly. Materials methods Twenty-eight lymphoblastic leukemia were enrolled. was done at baseline 72 h after induction dose doxorubicin. Conventional tissue Doppler imaging parameters obtained compared. Results After doxorubicin, both ventricles developed systolic diastolic dysfunction. Tricuspid annular plane excursion significantly decreased (20.0±4.95 mm vs. 19.40±4.90 mm). Right ventricular myocardial performance index isovolumetric relaxation times increased (0.38±0.08 0.41±0.08 41.4±1.8 ms 43.1±12.6 ms, p<0.05, respectively). E velocity (62.3±8.35 cm/s 60.1±7.34 cm/s, p<0.01) as well tricuspid E/A ratio (1.54±0.26 1.40±0.23, p<0.01). left fractional shortening ejection fraction (32.1±2.26% 31.4±2.27% 64.60±4.69% 63.10±4.63%, Left (0.44±0.05 0.46±0.06 58.6±8.75 60.3±10.1 Mitral reduced (85.6±11.3 83±11.9 cm/s) also (1.78±0.43 1.63±0.39). Conclusion Both dysfunctions are seen should for early diagnosis timely initiation management prevent progression.

Язык: Английский

The Tei Index Identifies a Differential Effect on Left and Right Ventricular Function with Low-dose Anthracycline Chemotherapy DOI
Mark Belham,

Anton Kruger,

Colin Pritchard

и другие.

Journal of the American Society of Echocardiography, Год журнала: 2006, Номер 19(2), С. 206 - 210

Опубликована: Фев. 1, 2006

Язык: Английский

Процитировано

30
Acute Ventricular Dysfunction After Doxorubicin-Based Induction Therapy for Pediatric Acute Lymphoblastic Leukemia DOI Open Access
Rajkumar Kundavaram, Amber Kumar,

Sushma Konnepati

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Дек. 14, 2024

Background Doxorubicin is an important drug used in the treatment of children with acute leukemia, and cardiotoxicity most serious complication due to its use. The cardiac dysfunction doxorubicin can be acute, early, or late. Echocardiography a non-invasive tool employed detect clinical subclinical plan strategies accordingly. Materials methods Twenty-eight lymphoblastic leukemia were enrolled. was done at baseline 72 h after induction dose doxorubicin. Conventional tissue Doppler imaging parameters obtained compared. Results After doxorubicin, both ventricles developed systolic diastolic dysfunction. Tricuspid annular plane excursion significantly decreased (20.0±4.95 mm vs. 19.40±4.90 mm). Right ventricular myocardial performance index isovolumetric relaxation times increased (0.38±0.08 0.41±0.08 41.4±1.8 ms 43.1±12.6 ms, p<0.05, respectively). E velocity (62.3±8.35 cm/s 60.1±7.34 cm/s, p<0.01) as well tricuspid E/A ratio (1.54±0.26 1.40±0.23, p<0.01). left fractional shortening ejection fraction (32.1±2.26% 31.4±2.27% 64.60±4.69% 63.10±4.63%, Left (0.44±0.05 0.46±0.06 58.6±8.75 60.3±10.1 Mitral reduced (85.6±11.3 83±11.9 cm/s) also (1.78±0.43 1.63±0.39). Conclusion Both dysfunctions are seen should for early diagnosis timely initiation management prevent progression.

Язык: Английский

Процитировано

0