Frontiers in Immunology,
Год журнала:
2018,
Номер
9
Опубликована: Май 8, 2018
Glioblastomas
(GBMs)
are
the
most
common
and
aggressive
primary
brain
tumors.
Due
to
their
malignant
growth
invasion
into
parenchyma
coupled
with
resistance
therapy,
GBMs
among
deadliest
of
all
cancers.
highly
heterogeneous
at
both
molecular
histological
levels.
Hallmark
structures
include
pseudopalisading
necrosis
microvascular
proliferation.
In
addition
high
levels
intratumoral
heterogeneity,
also
exhibit
inter-tumoral
heterogeneity.
The
major
non-neoplastic
cell
population
in
GBM
microenvironment
includes
cells
innate
immune
system
called
tumor-associated
macrophages
(TAMs).
Correlative
data
from
literature
suggest
that
molecularly
distinct
subtypes
differences
microenvironment.
Data
mouse
models
genetic
driver
mutations
can
create
unique
microenvironments.
Here,
we
review
origin,
features,
functions
TAMs
subtypes.
We
discuss
interactions
other
constituents
prospects
therapeutically
targeting
increase
efficacy
T-cell
functions.
Journal of Biomedical Science,
Год журнала:
2019,
Номер
26(1)
Опубликована: Окт. 19, 2019
In
many
solid
tumor
types,
tumor-associated
macrophages
(TAMs)
are
important
components
of
the
microenvironment
(TME).
Moreover,
TAMs
infiltration
is
strongly
associated
with
poor
survival
in
patients.
this
review,
we
describe
origins
and
their
polarization
state
dictated
by
TME.
We
also
specifically
focus
on
role
promoting
growth,
enhancing
cancer
cells
resistance
to
chemotherapy
radiotherapy,
angiogenesis,
inducing
migration
invasion
metastasis,
activating
immunosuppression.
addition,
discuss
can
be
used
as
therapeutic
targets
clinics.
The
strategies
include
clearing
inhibiting
activation
TAMs,
macrophage
phagocytic
activity,
limiting
monocyte
recruitment
other
targeted
therapies.
Neuro-Oncology,
Год журнала:
2020,
Номер
22(8), С. 1073 - 1113
Опубликована: Апрель 20, 2020
Abstract
Glioblastomas
are
the
most
common
form
of
malignant
primary
brain
tumor
and
an
important
cause
morbidity
mortality.
In
recent
years
there
have
been
advances
in
understanding
molecular
pathogenesis
biology
these
tumors,
but
this
has
not
translated
into
significantly
improved
outcomes
for
patients.
consensus
review
from
Society
Neuro-Oncology
(SNO)
European
Association
(EANO),
current
management
isocitrate
dehydrogenase
wildtype
(IDHwt)
glioblastomas
will
be
discussed.
addition,
novel
therapies
such
as
targeted
therapies,
agents
targeting
DNA
damage
response
metabolism,
immunotherapies,
viral
reviewed,
well
challenges
future
directions
research.
Neuro-Oncology,
Год журнала:
2016,
Номер
19(1), С. 139 - 141
Опубликована: Сен. 30, 2016
the
effects
they
observed
could
be
influenced
by
inhibition
of
other
types
Trk
receptors
or
signaling
molecules
downstream
Trk.We
have
recently
started
a
series
experiments
aiming
to
verify
whether
specific
TrkB
reduces
glioma
cell
proliferation
using
ANA-12,
small-molecule
selective
antagonist.Our
first
results
showed
that
ANA-12
effectively
and
dose-dependently
viability
human
glioblastoma
line
with
almost
complete
disappearance
cultured
cells
72
hours
after
treatment
(Fig.
1).Therefore,
might
prove
an
effective
experimental
therapeutic
strategy,
possibly
fewer
off-target
toxicities
compared
multitarget
drugs
in
patients
astrocytomas
harboring
oncogenic
TrkB.
Genomics Proteomics & Bioinformatics,
Год журнала:
2021,
Номер
19(1), С. 1 - 12
Опубликована: Фев. 1, 2021
Gliomas
are
the
most
common
and
malignant
intracranial
tumors
in
adults.
Recent
studies
have
revealed
significance
of
functional
genomics
for
glioma
pathophysiological
treatments.
However,
access
to
comprehensive
genomic
data
analytical
platforms
is
often
limited.
Here,
we
developed
Chinese
Glioma
Genome
Atlas
(CGGA),
a
user-friendly
portal
storage
interactive
exploration
cross-omics
data,
including
nearly
2000
primary
recurrent
samples
from
cohort.
Currently,
open
provided
whole-exome
sequencing
(286
samples),
mRNA
(1018
samples)
microarray
(301
DNA
methylation
(159
microRNA
(198
detailed
clinical
information
(age,
gender,
chemoradiotherapy
status,
WHO
grade,
histological
type,
critical
molecular
pathological
information,
survival
data).
In
addition,
several
tools
users
analyze
mutation
profiles,
mRNA/microRNA
expression,
perform
gene
correlation
analyses
specific
subtypes.
This
database
removes
barriers
researchers,
providing
rapid
convenient
high-quality
resources
biological
applications.
CGGA
available
at
http://www.cgga.org.cn.
