Frontiers in Immunology,
Год журнала:
2018,
Номер
9
Опубликована: Май 8, 2018
Glioblastomas
(GBMs)
are
the
most
common
and
aggressive
primary
brain
tumors.
Due
to
their
malignant
growth
invasion
into
parenchyma
coupled
with
resistance
therapy,
GBMs
among
deadliest
of
all
cancers.
highly
heterogeneous
at
both
molecular
histological
levels.
Hallmark
structures
include
pseudopalisading
necrosis
microvascular
proliferation.
In
addition
high
levels
intratumoral
heterogeneity,
also
exhibit
inter-tumoral
heterogeneity.
The
major
non-neoplastic
cell
population
in
GBM
microenvironment
includes
cells
innate
immune
system
called
tumor-associated
macrophages
(TAMs).
Correlative
data
from
literature
suggest
that
molecularly
distinct
subtypes
differences
microenvironment.
Data
mouse
models
genetic
driver
mutations
can
create
unique
microenvironments.
Here,
we
review
origin,
features,
functions
TAMs
subtypes.
We
discuss
interactions
other
constituents
prospects
therapeutically
targeting
increase
efficacy
T-cell
functions.
Genes & Development,
Год журнала:
2019,
Номер
33(11-12), С. 591 - 609
Опубликована: Июнь 1, 2019
Glioblastoma
ranks
among
the
most
lethal
of
all
human
cancers.
Glioblastomas
display
striking
cellular
heterogeneity,
with
stem-like
glioblastoma
stem
cells
(GSCs)
at
apex.
Although
original
identification
GSCs
dates
back
more
than
a
decade,
purification
and
characterization
remains
challenging.
Despite
these
challenges,
evidence
that
play
important
roles
in
tumor
growth
response
to
therapy
has
grown.
Like
normal
cells,
are
functionally
defined
distinguished
from
their
differentiated
progeny
core
transcriptional,
epigenetic,
metabolic
regulatory
levels,
suggesting
no
single
therapeutic
modality
will
be
universally
effective
against
heterogenous
GSC
population.
induce
systemic
immunosuppression
mixed
responses
oncoimmunologic
modalities,
potential
for
augmentation
deeper
consideration
GSCs.
Unfortunately,
literature
been
complicated
by
frequent
use
inferior
cell
lines
lack
proper
functional
analyses.
Collectively,
offers
reliable
cancer
study
better
model
disease
inform
improved
biologic
understanding
design
novel
therapeutics.
Frontiers in Immunology,
Год журнала:
2018,
Номер
9
Опубликована: Май 8, 2018
Glioblastomas
(GBMs)
are
the
most
common
and
aggressive
primary
brain
tumors.
Due
to
their
malignant
growth
invasion
into
parenchyma
coupled
with
resistance
therapy,
GBMs
among
deadliest
of
all
cancers.
highly
heterogeneous
at
both
molecular
histological
levels.
Hallmark
structures
include
pseudopalisading
necrosis
microvascular
proliferation.
In
addition
high
levels
intratumoral
heterogeneity,
also
exhibit
inter-tumoral
heterogeneity.
The
major
non-neoplastic
cell
population
in
GBM
microenvironment
includes
cells
innate
immune
system
called
tumor-associated
macrophages
(TAMs).
Correlative
data
from
literature
suggest
that
molecularly
distinct
subtypes
differences
microenvironment.
Data
mouse
models
genetic
driver
mutations
can
create
unique
microenvironments.
Here,
we
review
origin,
features,
functions
TAMs
subtypes.
We
discuss
interactions
other
constituents
prospects
therapeutically
targeting
increase
efficacy
T-cell
functions.
