Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)
Опубликована: Янв. 21, 2022
RNA demethylase ALKBH5 takes part in the modulation of N
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Сен. 22, 2022
RNA modifications have become hot topics recently. By influencing processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology. The immune abnormality in human diseases is also a research focus progressing rapidly these years. Studies demonstrated that participate the multiple biological processes cells, development, differentiation, activation, migration, polarization, thereby modulating responses are involved some related diseases. In this review, we present existing knowledge functions underlying mechanisms modifications, N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), N4-acetylcytosine (ac4C), pseudouridine (Ψ), uridylation, adenosine-to-inosine (A-to-I) editing, summarize their roles Via regulating can pathogenesis diseases, such cancers, infection, inflammatory autoimmune We further highlight challenges future directions based on knowledge. All all, review will provide helpful well novel ideas for researchers area.
Язык: Английский
Процитировано
210
Cancer Cell, Год журнала: 2021, Номер 39(7), С. 945 - 957.e10
Опубликована: Май 20, 2021
Язык: Английский
Процитировано
203
Journal of Hematology & Oncology, Год журнала: 2021, Номер 14(1)
Опубликована: Июль 27, 2021
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects fates of modified RNAs, including their stability, splicing, and/or translation, thus plays important roles posttranscriptional regulation. To date, m6A methyltransferases have been reported to execute deposition on distinct RNAs by own or forming different complexes additional partner proteins. In this review, we summarize function these regulating key genes pathways cancer biology. We also highlight progress use mediating therapy resistance, chemotherapy, targeted therapy, immunotherapy radiotherapy. Finally, discuss current approaches clinical potential methyltransferase-targeting strategies.
Язык: Английский
Процитировано
191
Frontiers in Oncology, Год журнала: 2021, Номер 11
Опубликована: Март 29, 2021
The attachment of cells to the extracellular matrix (ECM) is hallmark structure–function stability and well-being. ECM detachment in localized tumors precedes abnormal dissemination tumor culminating metastasis. Programmed cell death (PCD) activated during tumorigenesis clear off ECM-detached through “anoikis.” However, cancer develop several mechanisms for abrogating anoikis, thus promoting their invasiveness Specific factors, such as growth proteins, pH, transcriptional signaling pathways, oxidative stress, have been reported drivers anoikis resistance, enhancing proliferation Recent studies highlighted key contributions metabolic enabling bypass anoikis. Therefore, understanding driving resistance could help counteract progression prevent This review elucidates dynamics employed by impede proliferation, invasion, In addition, authors discussed other intermediates (especially amino acids nucleotides) that are less explored, which be crucial
Язык: Английский
Процитировано
190
Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(8), С. 507 - 526
Опубликована: Май 23, 2023
Язык: Английский
Процитировано
190
Cancer Cell, Год журнала: 2022, Номер 40(12), С. 1566 - 1582.e10
Опубликована: Окт. 27, 2022
Язык: Английский
Процитировано
188
Cancer Cell, Год журнала: 2021, Номер 39(7), С. 958 - 972.e8
Опубликована: Май 27, 2021
Язык: Английский
Процитировано
186
Trends in Genetics, Год журнала: 2021, Номер 38(2), С. 182 - 193
Опубликована: Июль 19, 2021
Chemical modifications on histones, DNA, and RNA robustly impact gene regulation. Installation of the modification m6A leads to altered mRNA stability translation. Emerging data suggest that perturbations in feedback epigenetic checkpoints vice versa.RNA methylation intracisternal A particle, a type repetitive element, is required for proper heterochromatin formation maintain genome integrity.Loss mouse embryonic stem cells enhances chromatin-associated RNAs, leading more-open chromatin active transcription.m6A destabilizes transcripts encode histone-modifying enzymes complexes, including KDM6B, CBP, P300.The histone elongation mark H3K36me3 guides deposition.Xist-mediated silencing X chromosome requires deposition recognition by reader proteins.m6A influence extends beyond stability, investigation functional effects biogenesis should be considered physiological mechanistic studies. Epigenetic occur genomic DNA histones expression. More recently, discovery undergoes similar chemical powerfully transcript turnover translation adds another layer dynamic Central precise synchronized regulation expression intricate crosstalk between multiple involved biosynthesis processing. There are more than 100 internal mammalian cells. The most common N6-methyladenosine (m6A) methylation. Although established dynamics efficiency, rapidly accumulating evidence shows significant histone/DNA mechanisms. These interactions specify transcriptional outputs, translation, recruitment modifiers, as well deployment methyltransferase complex (MTC) at target sites. In this review, we dissect m6A-orchestrated circuits regulate activity regulatory such long noncoding (lnc)RNA chromosome-associated RNA. Collectively, body suggests acts versatile checkpoint can couple different layers with one another.
Язык: Английский
Процитировано
183
Cancer Communications, Год журнала: 2022, Номер 42(2), С. 117 - 140
Опубликована: Янв. 12, 2022
Abstract With the development of proteomics and epigenetics, a large number RNA‐binding proteins (RBPs) have been discovered in recent years, interaction between long non‐coding RNAs (lncRNAs) RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on lncRNA‐RBP network, especially context its role occurrence cancer. Increasing evidence demonstrated that interactions play vital cancer progression; therefore, targeting these could provide new insights for drug discovery. In this review, we discussed how lncRNAs can interact with regulate their localization, modification, stability, activity effects transport, transcription, localization lncRNAs. Moreover, explored regulation influence lncRNAs, RBPs, downstream pathways are related development, such as N6‐methyladenosine (m6A) modification addition, network regulates cell phenotypes, proliferation, apoptosis, metastasis, resistance, immunity, tumor environment, metabolism. Furthermore, summarized therapeutic strategies target network. Although treatments still experimental stage various theories processes being studied, believe may ideas treatment.
Язык: Английский
Процитировано
182
Molecular Cancer, Год журнала: 2022, Номер 21(1)
Опубликована: Янв. 28, 2022
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic recent years. M6A plays multifunctional roles normal abnormal biological processes, its role may vary greatly depending on position m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis ferroptosis, which involve breakdown plasma membrane. Based implications methylation PCD, regulators functional were comprehensively studied reported. In this review, we focus high-complexity links between different types PCD pathways, are then closely associated with initiation, progression resistance cancer. Herein, clarifying relationship is great significance to provide novel strategies for cancer treatment, potential prospect clinical application.
Язык: Английский
Процитировано
177