Nature reviews. Cancer, Год журнала: 2023, Номер 23(6), С. 372 - 390
Опубликована: Апрель 24, 2023
Язык: Английский
Nature reviews. Cancer, Год журнала: 2023, Номер 23(6), С. 372 - 390
Опубликована: Апрель 24, 2023
Язык: Английский
Cancer Discovery, Год журнала: 2022, Номер 12(1), С. 31 - 46
Опубликована: Янв. 1, 2022
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity phenotypes and genotypes into provisional set underlying principles. As knowledge mechanisms has progressed, other facets disease have emerged as potential refinements. Herein, prospect raised that phenotypic plasticity disrupted differentiation discrete hallmark capability, nonmutational epigenetic reprogramming polymorphic microbiomes both constitute distinctive enabling characteristics facilitate acquisition capabilities. Additionally, senescent cells, varying origins, may be added to roster functionally important cell types in tumor microenvironment. SIGNIFICANCE: Cancer daunting breadth scope its diversity, spanning genetics, tissue biology, pathology, response therapy. Ever more powerful experimental computational tools technologies are providing an avalanche "big data" about myriad manifestations diseases encompasses. integrative concept embodied helping distill this increasingly logical science, new dimensions presented perspective add value endeavor, fully understand development malignant progression, apply medicine.
Язык: Английский
Процитировано
3364Cell, Год журнала: 2023, Номер 186(8), С. 1564 - 1579
Опубликована: Апрель 1, 2023
Язык: Английский
Процитировано
383Nature Genetics, Год журнала: 2022, Номер 54(8), С. 1192 - 1201
Опубликована: Авг. 1, 2022
Язык: Английский
Процитировано
307Nature Cancer, Год журнала: 2022, Номер 3(4), С. 386 - 401
Опубликована: Апрель 28, 2022
Язык: Английский
Процитировано
296Cancer Discovery, Год журнала: 2021, Номер 11(4), С. 971 - 994
Опубликована: Апрель 1, 2021
Abstract Metastasis is initiated and sustained through therapy by cancer cells with stem-like immune-evasive properties, termed metastasis-initiating (MIC). Recent progress suggests that MICs result from the adoption of a normal regenerative progenitor phenotype malignant cells, intrinsic programs to survive stresses metastatic process, undergo epithelial–mesenchymal transitions, enter slow-cycling states for dormancy, evade immune surveillance, establish supportive interactions organ-specific niches, co-opt systemic factors growth recurrence after therapy. Mechanistic understanding molecular mediators MIC phenotypes host tissue ecosystems could yield therapeutics improve patient outcomes. Significance: Understanding origins, traits, vulnerabilities capacity initiate metastasis in distant organs, microenvironments support ability these surveillance regenerate tumor, critical developing strategies prevention treatment advanced cancer. Leveraging recent our here we review nature their offer perspective on how this knowledge informing innovative treatments cancers.
Язык: Английский
Процитировано
260Trends in Cell Biology, Год журнала: 2021, Номер 31(4), С. 298 - 310
Опубликована: Янв. 28, 2021
Язык: Английский
Процитировано
245Developmental Cell, Год журнала: 2022, Номер 57(4), С. 543 - 560.e9
Опубликована: Фев. 1, 2022
In all multicellular organisms, transcriptional networks orchestrate organ development. The Arabidopsis root, with its simple structure and indeterminate growth, is an ideal model for investigating the spatiotemporal signatures underlying developmental trajectories. To map gene expression dynamics across root cell types time, we built a comprehensive, organ-scale atlas at single-cell resolution. addition to estimating progressions in pseudotime, employed mathematical concept of optimal transport infer trajectories identify their regulators. demonstrate utility interpret new datasets, profiled mutants two key regulators resolution, shortroot scarecrow. We report transcriptomic vivo evidence tissue trans-differentiation mixed identity phenotype Our results support as rich community resource unraveling programs that specify maintain regulate
Язык: Английский
Процитировано
245Journal of Hepatology, Год журнала: 2021, Номер 75(6), С. 1397 - 1408
Опубликована: Июнь 30, 2021
Язык: Английский
Процитировано
239Nature reviews. Cancer, Год журнала: 2021, Номер 21(6), С. 379 - 392
Опубликована: Март 16, 2021
Язык: Английский
Процитировано
229Cell, Год журнала: 2022, Номер 185(11), С. 1905 - 1923.e25
Опубликована: Май 1, 2022
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth expansion to neighboring distal tissues. The study phylogenetic relationships between cancer cells provides key insights into these processes. Here, we introduced an evolving lineage-tracing system with a single-cell RNA-seq readout mouse model Kras;Trp53(KP)-driven lung adenocarcinoma tracked tumor from single-transformed metastatic tumors at unprecedented resolution. We found loss initial, stable alveolar-type2-like state was accompanied transient increase in plasticity. This followed adoption distinct transcriptional programs rapid and, ultimately, clonal sweep subclones capable metastasizing. Finally, develop through stereotypical evolutionary trajectories, perturbing additional suppressors accelerates progression creating novel trajectories. Our elucidates hierarchical nature more broadly, enables in-depth studies progression.
Язык: Английский
Процитировано
226