T cells in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 19, 2023

T cells are crucial for immune functions to maintain health and prevent disease. cell development occurs in a stepwise process the thymus mainly generates CD4

Язык: Английский

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Metabolic programming and immune suppression in the tumor microenvironment

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 421 - 433

Опубликована: Фев. 16, 2023

Язык: Английский

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Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 450 - 465

Опубликована: Март 1, 2023

Язык: Английский

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The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Май 24, 2022

Recently, in the field of cancer treatment, paradigm has changed to immunotherapy that activates immune system induce attacks. Among them, checkpoint inhibitors (ICI) are attracting attention as excellent and continuous clinical results. However, it shows not only limitations such efficacy some patients or indications, but also side-effects resistance occur. Therefore, is necessary understand factors tumor microenvironment (TME) affect immunotherapy, is, mechanism by which grows while evading suppressing attacks from within TME. Tumors can evade through various mechanisms restricting antigen recognition, inhibiting system, inducing T cell exhaustion. In addition, tumors inhibit accumulating specific metabolites signal TME limiting nutrients available cells. order overcome develop effective treatments therapeutic strategies, an approach needed functions cells integrated manner based on this review, we will examine effects cells, especially how anti-cancer strategies

Язык: Английский

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Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Сен. 6, 2022

Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as primary carbon fuel source for many cell types. In the tumor-immune microenvironment, effect lactate on cancer and immune cells can be highly complex hard to decipher, which further confounded by acidic protons, co-product glycolysis. Here we show that able increase stemness CD8

Язык: Английский

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Metabolic communication in the tumour–immune microenvironment

Nature Cell Biology, Год журнала: 2022, Номер 24(11), С. 1574 - 1583

Опубликована: Окт. 13, 2022

Язык: Английский

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Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11943 - 11943

Опубликована: Окт. 8, 2022

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, has long been recognized as a waste product. Lactate the acidification tumor microenvironment (TME) promote key carcinogenesis processes, including angiogenesis, invasion, metastasis, immune escape. Notably, histone lysine lactylation (Kla) was identified novel post-modification (PTM), providing new perspective on mechanism by which functions promising potential therapy for tumors target. Further studies have confirmed that protein is essential to function; it involves important life activities such glycolysis-related cell macrophage polarization. This review systematically elucidates role an immunosuppressive molecule from aspects metabolism effects or non-histone cells; provides ideas further understanding in elucidating regulation function. We explored possibility targeting targets cancer treatment. Finally, propose combined strategy inhibiting glycolytic pathway immunotherapy.

Язык: Английский

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Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Ноя. 1, 2022

Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark cancer, Warburg effect promotes metastasis remodels tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation drug resistance. Targeting metabolism would be promising method for treatment CRC. In this review, we summarize information about roles in microenvironment to elucidate mechanisms governing identify novel targets therapy.

Язык: Английский

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The multiple roles of LDH in cancer

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 19(12), С. 749 - 762

Опубликована: Окт. 7, 2022

Язык: Английский

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Mechanisms driving the immunoregulatory function of cancer cells

Nature reviews. Cancer, Год журнала: 2023, Номер 23(4), С. 193 - 215

Опубликована: Янв. 30, 2023

Язык: Английский

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