Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 22, 2025
Molecular
imaging
technologies
have
significantly
transformed
cancer
research
and
clinical
practice,
offering
valuable
tools
for
visualizing
understanding
the
complex
tumor
immune
microenvironment.
These
allow
non-invasive
examination
of
key
components
within
microenvironment,
including
cells,
cytokines,
stromal
providing
crucial
insights
into
biology
treatment
responses.
This
paper
reviews
latest
advancements
in
molecular
imaging,
with
a
focus
on
its
applications
assessing
interactions
Additionally,
challenges
faced
by
are
discussed,
such
as
need
highly
sensitive
specific
agents,
issues
data
integration,
difficulties
translation.
The
future
outlook
emphasizes
potential
to
enhance
personalized
through
integration
artificial
intelligence
development
novel
probes.
Addressing
these
is
essential
fully
realizing
improving
diagnosis,
treatment,
patient
outcomes.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 9, 2023
Tertiary
lymphoid
structures
(TLSs)
are
clusters
of
cells
with
an
organization
that
resembles
secondary
organs.
Both
share
common
developmental
characteristics,
although
TLSs
usually
appear
in
chronically
inflamed
non-lymphoid
tissues,
such
as
tumors.
contain
diverse
types
immune
cells,
varying
degrees
spatial
represent
different
stages
maturation.
These
support
both
humoral
and
cellular
responses,
thus
the
correlation
between
existence
TLS
clinical
outcomes
cancer
patients
has
been
extensively
studied.
The
finding
associated
better
prognosis
some
led
to
design
therapeutic
strategies
based
on
promoting
formation
these
structures.
Agents
chemokines,
cytokines,
antibodies
vaccines
have
used
combination
traditional
antitumor
treatments
enhance
generation,
good
results.
induction
therefore
represents
a
novel
promising
avenue
for
treatment
number
tumor
types.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 22, 2024
Background:
Glucagon-like
peptide-1
(GLP-1)
has
crucial
impact
on
glycemic
control
and
weight
loss
physiologically.
GLP-1
receptor
agonists
have
been
approved
for
treatment
of
diabetes
obesity.
Emerging
evidence
suggests
that
exert
anticancer
effect
in
tumorigenesis
development.
However,
the
role
mechanism
signaling-related
genes
pan-cancer
still
need
further
study.
Methods:
We
comprehensively
investigated
aberrant
expression
genetic
alterations
33
cancer
types.
Next,
signaling
score
each
patient
The
Cancer
Genome
Atlas
were
established
by
single-sample
gene
set
enrichment
analysis.
In
addition,
we
explored
association
with
prognostic
significance
immune
characteristics.
Furthermore,
qRT-PCR
immunohistochemistry
staining
applied
to
verify
profiling
colorectal
(CRC)
tissues.
Wound-healing
assays
migration
carried
out
validate
agonist
CRC
cell
lines.
Results:
is
commonly
altered
pan-cancer.
was
decreased
tissues
compared
normal
lower
associated
worse
survival
most
Notably,
strongly
correlated
infiltration,
including
T
cells,
neutrophils,
dendritic
cells
macrophages.
exhibited
close
tumor
mutation
burden,
microsatellite
instability
immunotherapy
response
patients
cancer.
Moreover,
found
ITPR1
ADCY5
significantly
reduced
tissues,
semaglutide
impaired
capacity
indicating
its
protective
role.
Conclusion:
This
study
provided
a
preliminary
understanding
pan-cancer,
showing
prognosis
potential
immunotherapeutic
values
types,
verified
CRC.
Liver
metastases
are
commonly
detected
in
the
advanced
stages
of
various
malignant
tumors,
representing
a
significant
clinical
challenge.
Throughout
process
liver
formation,
immune
cells
play
pivotal
role,
particularly
pre-metastatic
and
metastatic
niches
within
liver.
Immune
establish
extensive
intricate
interactions
with
tumor
other
components
liver,
collectively
promoting
sustaining
growth
metastases.
Despite
limited
efficacy
existing
therapeutic
modalities
against
some
metastases,
novel
immune-based
treatment
approaches
continuously
being
explored
validated.
Building
on
systematic
elucidation
immunosuppressive
characteristics
we
potential
immunotherapies
applicable
to
patients
from
multiple
dimensions.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 22, 2025
Molecular
imaging
technologies
have
significantly
transformed
cancer
research
and
clinical
practice,
offering
valuable
tools
for
visualizing
understanding
the
complex
tumor
immune
microenvironment.
These
allow
non-invasive
examination
of
key
components
within
microenvironment,
including
cells,
cytokines,
stromal
providing
crucial
insights
into
biology
treatment
responses.
This
paper
reviews
latest
advancements
in
molecular
imaging,
with
a
focus
on
its
applications
assessing
interactions
Additionally,
challenges
faced
by
are
discussed,
such
as
need
highly
sensitive
specific
agents,
issues
data
integration,
difficulties
translation.
The
future
outlook
emphasizes
potential
to
enhance
personalized
through
integration
artificial
intelligence
development
novel
probes.
Addressing
these
is
essential
fully
realizing
improving
diagnosis,
treatment,
patient
outcomes.
