Cancers,
Год журнала:
2023,
Номер
15(15), С. 3913 - 3913
Опубликована: Авг. 1, 2023
GIM
is
a
persistent,
premalignant
lesion
whereby
gastric
mucosa
replaced
by
metaplastic
resembling
intestinal
tissue,
arising
in
the
setting
of
chronic
inflammation,
particularly
context
Helicobacter
pylori.
While
overall
rates
progression
to
adenocarcinoma
are
low,
estimated
at
from
0.25
2.5%,
there
features
that
confer
much
higher
risk
and
warrant
follow-up.
In
this
review,
we
collate
summarise
current
knowledge
regarding
pathogenesis
GIM,
clinical,
endoscopic
histologic
factors
for
cancer.
We
examine
state-of-practice
with
regard
diagnosis
management
which
varies
widely
published
guidelines
practice.
consider
emerging
evidence
population
studies,
artificial
intelligence
molecular
markers,
will
guide
future
models
care.
The
ultimate
goal
increase
detection
early
dysplasia/neoplasia
can
be
cured
while
avoiding
unnecessary
surveillance
very
low-risk
individuals.
Cell,
Год журнала:
2024,
Номер
187(4), С. 882 - 896.e17
Опубликована: Янв. 30, 2024
Streptococcus
anginosus
(S.
anginosus)
was
enriched
in
the
gastric
mucosa
of
patients
with
cancer
(GC).
Here,
we
show
that
S.
colonized
mouse
stomach
and
induced
acute
gastritis.
infection
spontaneously
progressive
chronic
gastritis,
parietal
cell
atrophy,
mucinous
metaplasia,
dysplasia
conventional
mice,
findings
were
confirmed
germ-free
mice.
In
addition,
accelerated
GC
progression
carcinogen-induced
tumorigenesis
YTN16
allografts.
Consistently,
disrupted
barrier
function,
promoted
proliferation,
inhibited
apoptosis.
Mechanistically,
identified
an
surface
protein,
TMPC,
interacts
Annexin
A2
(ANXA2)
receptor
on
epithelial
cells.
Interaction
TMPC
ANXA2
mediated
attachment
colonization
mitogen-activated
protein
kinase
(MAPK)
activation.
knockout
abrogated
induction
MAPK
by
anginosus.
Thus,
this
study
reveals
as
a
pathogen
promotes
via
direct
interactions
cells
TMPC-ANXA2-MAPK
axis.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging
is
a
multifaceted
process
influenced
by
hereditary
factors,
lifestyle,
and
environmental
elements.
As
time
progresses,
the
human
body
experiences
degenerative
changes
in
major
functions.
The
external
internal
signs
of
aging
manifest
various
ways,
including
skin
dryness,
wrinkles,
musculoskeletal
disorders,
cardiovascular
diseases,
diabetes,
neurodegenerative
cancer.
Additionally,
cancer,
like
aging,
complex
disease
that
arises
from
accumulation
genetic
epigenetic
alterations.
Circadian
clock
dysregulation
has
recently
been
identified
as
an
important
risk
factor
for
cancer
development.
Natural
compounds
herbal
medicines
have
gained
significant
attention
their
potential
preventing
age-related
diseases
inhibiting
progression.
These
demonstrate
antioxidant,
anti-inflammatory,
anti-proliferative,
pro-apoptotic,
anti-metastatic,
anti-angiogenic
effects
well
circadian
regulation.
This
review
explores
cancers,
specific
natural
targeting
key
features
these
conditions.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 12, 2024
Organoids
are
approved
by
the
US
FDA
as
an
alternative
to
animal
experiments
guide
drug
development
and
for
sensitivity
screening.
Stable
organoids
models
of
gastric
cancer
desirable
personalized
medicine
Tumor
tissues
from
a
primary
stomach
metastatic
lymph
node
were
collected
3D
culture.
By
long-term
culture
over
50
generations
in
vitro,
we
obtained
stably
growing
organoid
lines.
We
analyzed
short
tandem
repeats
(STRs)
karyotypes
cells,
tumorigenesis
nude
mice,
well
multi-omics
profiles
organoids.
A
CCK8
method
was
used
determine
drugs
fluorouracil
(5-Fu),
platinum
paclitaxel.
Paired
lines
(SPDO1P)
(SPDO1LM)
established
with
unique
STRs
karyotypes.
The
resulted
vivo
had
clear
genetic
profiles.
Compared
SPDO1P
cancer,
upregulated
genes
SPDO1LM
enriched
pathways
epithelial-mesenchymal
transition
angiogenesis
stronger
abilities
cell
migration,
invasion,
pro-angiogenesis.
Based
on
analysis,
SOX
regimen
(5-Fu
plus
oxaliplatin)
chemotherapy
optimal
clinical
outcome.
recapitulate
parental
tissues.
paired
present
step-change
toward
living
biobanks
further
translational
usage.
Cancer Immunology Immunotherapy,
Год журнала:
2024,
Номер
73(11)
Опубликована: Сен. 13, 2024
Gastric
cancer
(GC)
is
a
highly
heterogeneous
disease
with
complex
tumor
microenvironment
(TME)
that
encompasses
multiple
cell
types
including
cells,
immune
stromal
and
so
on.
Cancer-associated
cells
could
remodel
the
TME
influence
progression
of
GC
therapeutic
response.
Single-cell
RNA
sequencing
(scRNA-seq),
as
an
emerging
technology,
has
provided
unprecedented
insights
into
complicated
biological
composition
characteristics
at
molecular,
cellular,
immunological
resolutions,
offering
new
idea
for
studies.
In
this
review,
we
discuss
novel
findings
from
scRNA-seq
datasets
revealing
origin
evolution
GC,
powerful
tool
investigating
transcriptional
dynamics
intratumor
heterogeneity
(ITH)
in
GC.
Meanwhile,
demonstrate
vital
within
TME,
T
B
macrophages,
play
important
role
progression.
Additionally,
also
overview
how
facilitates
our
understanding
about
effects
on
individualized
therapy
patients.
Spatial
transcriptomes
(ST)
have
been
designed
to
determine
spatial
distribution
capture
local
intercellular
communication
networks,
enabling
further
relationship
between
background
particular
its
functions.
summary,
other
single-cell
technologies
provide
valuable
perspective
molecular
pathological
hold
promise
advancing
basic
research
clinical
practice
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 4, 2025
Abstract
Purpose
To
identify
key
cellular
changes
and
molecular
events
in
atrophic
mucosa,
we
aimed
to
elucidate
the
mechanisms
driving
occurrence
of
chronic
gastritis
(CAG).
Methods
We
used
single-cell
RNA
sequencing
(scRNA-seq)
characterize
epithelial
state
tissue
microenvironment
associated
with
CAG.
The
were
identified
by
comparing
differentially
expressed
genes
(DEGs)
between
two
mucosa
states.
Gene
Ontology
(GO)
pathway
enrichment
analysis
was
explore
potential
functional
each
cell
subtype
mucosa.
set
score
conducted
compare
roles
different
fibroblast
subtypes
CAG
control
groups.
Metabolic
performed
metabolic
activity
C1Q
+
macrophages
under
conditions.
NichNet
analyze
regulatory
relationships
CCL11
APOE
fibroblasts
CD8
effector
T
cells.
Transcription
factor
(TF)
determine
transcription
status
T-cell
normal
Results
generated
a
transcriptomic
atlas
from
3
biopsy
samples
paired
adjacent
tissues.
Our
revealed
that
chief
cells
parietal
exhibited
loss
detoxification
ability
surface
mucous
displayed
reduced
antimicrobial
defense
lesions.
neck
lesions
showed
upregulation
related
cycle
transition,
which
may
lead
aberrant
DNA
replication.
Additionally,
exhaustion
phenotype
infiltrated
condition.
phagocytosis,
downregulated
expression
pattern
recognition
receptors
decreased
activity.
subpopulation
CXCL11
regulated
inflammatory
response
pathogenesis
gastritis.
APSN
found
be
gastric
cancer
(GC)
development.
Conclusions
main
goal
this
study
comprehensively
observed
an
immune
decline
mucosal
during
development
CAG,
including
macrophages,
cytotoxicity
cells,
increased
infiltration
exhausted
Specifically,
demonstrated
aberrantly
express
susceptibility
external
bacterial
infection
progression.
provides
new
insights
into
functions
alterations
