Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 20, 2025
In
the
course
of
tumor
treatment,
radiation
therapy
(RT)
not
only
kills
cancer
cells,
but
also
induces
complex
biological
effects
in
non-malignant
cells
around
cells.
These
such
as
angiogenesis,
changes
stromal
composition
and
immune
cell
infiltration
remodel
microenvironment
(TME).
As
one
major
components
TME,
Cancer‑associated
fibroblasts
(CAFs)
are
involved
tumorigenesis,
progression,
recurrence,
metastasis
regulate
tumor-associated
microenvironment.
CAFs
or
have
intercellular
communication
context
radiation.
Main
content.
Different
cellular
precursors,
spatial
location
differences,
absence
specific
markers,
advances
single-cell
sequencing
technology
gradually
made
abundant
heterogeneity
well
known.
Due
to
unique
radioresistance
properties,
can
survive
under
high
doses
ionizing
However,
induce
phenotypic
functional
further
act
on
promote
inhibit
progression.
To
date,
effect
RT
irradiated
progression
TME
still
defined.
this
review,
we
review
origin,
phenotypic,
describe
CAFs,
focusing
mutual
crosstalk
between
after
We
discuss
emerging
strategies
for
targeted
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Фев. 18, 2025
Abstract
Breast
cancer,
characterized
by
unique
epidemiological
patterns
and
significant
heterogeneity,
remains
one
of
the
leading
causes
malignancy-related
deaths
in
women.
The
increasingly
nuanced
molecular
subtypes
breast
cancer
have
enhanced
comprehension
precision
treatment
this
disease.
mechanisms
tumorigenesis
progression
been
central
to
scientific
research,
with
investigations
spanning
various
perspectives
such
as
tumor
stemness,
intra-tumoral
microbiota,
circadian
rhythms.
Technological
advancements,
particularly
those
integrated
artificial
intelligence,
significantly
improved
accuracy
detection
diagnosis.
emergence
novel
therapeutic
concepts
drugs
represents
a
paradigm
shift
towards
personalized
medicine.
Evidence
suggests
that
optimal
diagnosis
models
tailored
individual
patient
risk
expected
are
crucial,
supporting
era
oncology
for
cancer.
Despite
rapid
advancements
increasing
emphasis
on
clinical
comprehensive
update
summary
panoramic
knowledge
related
disease
needed.
In
review,
we
provide
thorough
overview
global
status
including
its
epidemiology,
factors,
pathophysiology,
subtyping.
Additionally,
elaborate
latest
research
into
contributing
progression,
emerging
strategies,
long-term
management.
This
review
offers
valuable
insights
Cancer
Research,
thereby
facilitating
future
progress
both
basic
application.
Metabolic
alterations,
a
hallmark
of
cancer,
enable
tumor
cells
to
adapt
their
environment
by
modulating
glucose,
lipid,
and
amino
acid
metabolism,
which
fuels
rapid
growth
contributes
treatment
resistance.
In
primary
breast
metabolic
shifts
such
as
the
Warburg
effect
enhanced
lipid
synthesis
are
closely
linked
chemotherapy
failure.
Similarly,
metastatic
lesions
often
display
distinct
profiles
that
not
only
sustain
but
also
confer
resistance
targeted
therapies
immunotherapies.
The
review
emphasizes
two
major
aspects:
mechanisms
driving
in
both
how
unique
environments
sites
further
complicate
treatment.
By
targeting
vulnerabilities
at
stages,
new
strategies
could
improve
efficacy
existing
provide
better
outcomes
for
cancer
patients.
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Март 28, 2025
Cancer-associated
fibroblasts
(CAFs)
are
key
players
in
cancer
development
and
therapy,
they
exhibit
multifaceted
roles
the
tumor
microenvironment
(TME).
From
their
diverse
cellular
origins,
CAFs
undergo
phenotypic
functional
transformation
upon
interacting
with
cells
presence
can
adversely
influence
treatment
outcomes
severity
of
cancer.
Emerging
evidence
from
single-cell
RNA
sequencing
(scRNA-seq)
studies
have
highlighted
heterogeneity
plasticity
CAFs,
subtypes
identifiable
through
distinct
gene
expression
profiles
properties.
multiple
mechanisms,
including
regulation
extracellular
matrix
(ECM)
remodeling,
direct
promotion
growth
provision
metabolic
support,
promoting
epithelial-mesenchymal
transition
(EMT)
to
enhance
invasiveness
growth,
as
well
stimulating
stem
cell
properties
within
tumor.
Moreover,
induce
an
immunosuppressive
TME
contribute
therapeutic
resistance.
In
this
review,
we
summarize
fundamental
knowledge
recent
advances
regarding
focusing
on
sophisticated
potential
targets.
We
discuss
various
strategies
target
ECM
modulation,
elimination,
interruption
CAF-TME
crosstalk,
CAF
normalization,
approaches
developing
more
effective
treatments.
An
improved
understanding
complex
interplay
between
is
crucial
for
new
targeted
therapies
Epigenomic
modifications—such
as
DNA
methylation,
histone
acetylation,
and
methylation—and
their
implications
in
tumorigenesis,
progression,
treatment
have
emerged
a
pivotal
field
cancer
research.
Tumors
undergo
metabolic
reprogramming
to
sustain
proliferation
metastasis
nutrient-deficient
conditions,
while
suppressing
anti-tumor
immunity
the
tumor
microenvironment
(TME).
Concurrently,
immune
cells
within
immunosuppressive
TME
adaptations,
leading
alterations
function.
The
complicated
interplay
between
metabolites
epigenomic
modulation
has
spotlighted
significance
of
regulation
immunometabolism.
In
this
review,
characteristics
modification
associated
with
tumors
are
systematically
summarized
alongside
regulatory
roles
Classical
emerging
approaches
delineated
broaden
boundaries
research
on
crosstalk
immunometabolism
epigenomics.
Furthermore,
we
discuss
potential
therapeutic
strategies
that
target
modulate
modifications,
highlighting
burgeoning
synergy
therapies
immunotherapy
promising
avenue
for
treatment.
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Март 1, 2025
Esophageal
squamous
cell
carcinoma
(ESCC)
is
a
prevalent
and
aggressive
subtype
of
esophageal
cancer,
posing
significant
mortality
economic
burden,
especially
in
East
Southeast
Asia.
Current
therapeutic
strategies
have
limitations
improving
patient
survival,
particularly
regarding
disease
progression
resistance.
This
study
aimed
to
investigate
the
impact
neoadjuvant
chemoradiotherapy
(NCRT)
on
ESCC
microenvironment.
We
utilized
single-cell
RNA
sequencing
systematically
characterize
tumor
cancer-associated
fibroblasts
(CAFs)
subtypes.
Marker
genes
myofibroblastic
CAFs
(myCAFs)
were
employed
establish
prognostic
model
verify
its
application
other
datasets.
Other
experiments
conducted
clinical
samples
explore
potential
risk-related
genes.
Our
bioinformatics
statistical
analyses
revealed
an
increased
proportion
epithelial
cells
NCRT
identified
Ep_c1
associated
with
better
prognosis.
Further
results
indicated
complex
communication
network
between
myCAFs.
The
top
30
marker
myCAFs
used
construct
signature
response
immunotherapy.
Finally,
Complement
C1s
subcomponent
(C1S),
Decorin
(DCN),
Neuroblastoma
suppression
tumorigenicity
1
(NBL1)
as
findings
highlight
dynamic
alterations
post-NCRT
microenvironment
provide
foundation
for
development
personalized
treatment
immunotherapeutic
approaches.
Future
studies
are
warranted
further
validate
these
their
implications.
