Current Opinion in Immunology, Год журнала: 2024, Номер 91, С. 102499 - 102499
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(3), С. e010758 - e010758
Опубликована: Март 1, 2025
Objective Immune checkpoint inhibitors (ICIs) have significantly advanced cancer treatment, but they can also lead to immune-related adverse events (irAEs), including inflammatory arthritis. Understanding the risk factors and underlying mechanisms of irAE pathogenesis is crucial for optimal patient management. Increasing evidence suggests that ICI-mediated activation tissue-resident memory T cells (T RM ) eliminates associated with irAE-related colitis dermatitis. However, it remains unknown why development these irAEs restricted a subset patients. We hypothesized osteoarthritis (OA) tissue damage chronic inflammation recruitment differentiation joint cells, predisposing individuals ICI-induced Methods Using comprehensive approach, we compared prevalence OA in patients irAE-arthritis those non-arthritis without irAEs. Additionally, used immunophenotyping techniques characterize T-cell populations blood synovial fluid irAE-arthritis. Results Our findings revealed higher who developed than controls. Furthermore, multivariable analysis identified OA, body mass index, smoking as independent expressing programmed cell death protein-1 (PD-1) were predominant joints. These directly targeted by ICIs, resulting an immune response transition from Conclusion This study, first its kind, identifies significant factor irAEarthritis. It reveals potential mechanism which ICIs activate PD-1-positive joints, research could enhance management treatment receiving ICIs.
Язык: Английский
Процитировано
2
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Tissue-resident memory T (TRM) cells are a distinct subset of that persist in non-lymphoid tissues, providing localized and rapid immune responses to infection malignancy. Unlike circulating cells, TRM have unique homing functional characteristics shaped by the tissue microenvironment. In gut, play pivotal role maintaining mucosal immunity, exhibiting phenotypic heterogeneity different intestinal compartments response aging pathological conditions. This review aims systematically examine definition, spatial roles (iTRM) cells. It highlights their contributions physiological involvement processes such as inflammatory bowel disease (IBD) colorectal cancer (CRC), age-related dynamics. The also explores emerging therapeutic implications modulating iTRM for health management. KEY SCIENTIFIC CONCEPTS OF REVIEW: defined surface markers like CD69 CD103, transcriptional regulators Hobit, Runx3, Blimp-1, well cytokine signals including TGF-β, IFN-β, IL-12. They exhibit across layers (epithelium versus lamina propria) regions (small intestine colon). IBD, dual role, contributing both inflammation repair, whereas CRC, specific subsets (e.g., CD8+ CD103+ CD39+) associated with enhanced antitumor immunity. Aging impacts functionality, shifts CD4+/CD8+ ratio reduced production elderly individuals. Insights into metabolic, transcriptional, environmental regulation provide avenues targeted therapies diseases, immunotherapy, interventions delay aging.
Язык: Английский
Процитировано
1
Trends in Molecular Medicine, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Immune checkpoint inhibitors (ICIs) have led to improved outcome in patients with various types of cancer. Due inhibition physiological anti-inflammatory mechanisms, treated ICIs may develop autoimmune inflammation the colon, associated morbidity, decreased quality life (QoL), and mortality. In this review, we summarize clinical pathophysiological aspects immune-mediated colitis (ImC), highlighting novel treatment options. trigger resident circulating T cell activation infiltration myeloid cells. addition, gut microbiota critically contribute intestinal immune dysregulation loss barrier function, thereby propagating local systemic inflammation. Currently available therapies for ImC include corticosteroids, antitumor necrosis factor-α (TNF-α)- anti-integrin α
Язык: Английский
Процитировано
4
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
ABSTRACT CD8+ tissue‐resident memory T cells (TRM) are strategically located in peripheral tissues, enabling a rapid response to local infections, which is different from circulating cells. Their unique positioning makes them promising targets for vaccines designed enhance protection at barrier sites and other organs. Recent studies have shown correlation between TRM favorable clinical outcomes various types of cancer, indicating their potential role immune checkpoint blockade (ICB) therapies. However, the dual nature presents challenges, as inappropriate activation may lead autoimmunity chronic inflammatory conditions. This review highlights significant advancements field, focusing on differentiation pathways phenotypic heterogeneity across tissues disease states. We also protective roles contexts implications vaccine development against infections treatment strategies tumors. Overall, this comprehensive outlines common features cell biological functions, emphasizing specific characteristics diverse states, can guide design therapies tumors while minimizing risk autoimmune diseases.
Язык: Английский
Процитировано
0
Current Opinion in Immunology, Год журнала: 2024, Номер 91, С. 102499 - 102499
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0