AI model using clinical images for genomic prediction and tailored treatment in patients with cancer

The Lancet Oncology, Год журнала: 2025, Номер 26(3), С. e126 - e126

Опубликована: Март 1, 2025

Язык: Английский

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Histotechnology at the crossroad of spatial biology: bridging legacy and innovation

Journal of Histotechnology, Год журнала: 2025, Номер unknown, С. 1 - 6

Опубликована: Фев. 4, 2025

Язык: Английский

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Tumor-Agnostic Therapies in Practice: Challenges, Innovations, and Future Perspectives

Cancers, Год журнала: 2025, Номер 17(5), С. 801 - 801

Опубликована: Фев. 26, 2025

This review comprehensively analyzes the current landscape of tumor-agnostic therapies in oncology. Tumor-agnostic are designed to target specific molecular alterations rather than primary site tumor, representing a shift cancer treatment. We discuss recent approvals by regulatory agencies such as FDA and EMA, highlighting that have demonstrated efficacy across multiple types sharing common alterations. delve into trial methodologies underpin these approvals, emphasizing innovative designs basket trials umbrella trials. These present unique advantages, including increased efficiency patient recruitment ability assess drug diverse populations rapidly. However, they also entail certain challenges, need for robust biomarkers complexities requirements. Moreover, we examine promising prospects developing rare cancers exhibit targets typically associated with more prevalent malignancies. By synthesizing insights, this underscores transformative potential It offers pathway personalized treatment transcends conventional histology-based classification.

Язык: Английский

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Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

Cancer Cell, Год журнала: 2025, Номер 43(3), С. 380 - 397.e7

Опубликована: Март 1, 2025

Cancer development involves the co-evolution of cancer cells and their surrounding microenvironment, yet dynamics this interaction within physical architecture remains poorly understood. Here, we present a spatial transcriptomic map at single-cell resolution, encompassing 127 multi-stage fields view from 43 patients, to chart evolutionary trajectories human esophageal squamous cell carcinoma (ESCC). By analyzing 6.4 million cells, reveal that ESCC progression is driven by proliferative epithelial subpopulation acquires dedifferentiated invasive characteristics. At late precancerous stage, these disrupt epithelial-stromal interface recruit normal fibroblasts via JAG1-NOTCH1 signaling, transforming them into cancer-associated (CAFs). This leads formation "CAF-Epi" (CAF cell) niche tumor edge shields immune surveillance. The CAF-Epi key indicator in other carcinomas patient outcomes.

Язык: Английский

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Dynamic monitoring and multi-pathway regulation of FBXO21 in renal clear cell carcinoma: from static marker to perspective of precision therapy

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 11, 2025

Язык: Английский

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New horizons at the interface of artificial intelligence and translational cancer research

Cancer Cell, Год журнала: 2025, Номер 43(4), С. 708 - 727

Опубликована: Апрель 1, 2025

Язык: Английский

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Advances and applications of multiomics technologies in precision diagnosis and treatment for gastric cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189336 - 189336

Опубликована: Апрель 1, 2025

Язык: Английский

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